RESEARCH
探索生命的再生机制：解析人类疾病与衰老
再生是大自然最为神奇的现象之一，使得生物体能够修复和替代受损的组织。这一非凡的能力在动物界不同物种和不同器官广泛存在，但支配器官再生的细胞与分子机制仍然鲜为人知。我们的研究旨在揭示这些基础机制，探索驱动组织修复与再生的动态过程。
我们团队的研究工作以创新的模型系统为核心，力图提供前所未有的视角，深入解析影响再生潜力的遗传与环境因素。通过运用最前沿的技术，如功能基因组学、空间转录组学、单细胞RNA测序和高分辨率成像，我们正在解析跨物种的再生生物学细胞及分子机制。这种跨学科的研究方法使我们能够发现不同物种中再生的核心原理。
我们特别关注具有强大再生潜力的系统（如淡水涡虫）与再生能力有限的系统（如心脏）的比较研究，从而全面理解再生过程。这些研究不仅探索了不同物种如何利用独特的再生能力，也致力于将这些发现转化为改善人类再生疗法的关键技术。
我们最终的目标是利用再生的力量，推动新的治疗方法，用于对抗退行性疾病、促进组织修复，并延长人类的寿命。通过深入理解生物体如何实现再生，我们旨在革新再生医学，并为癌症相关的组织损伤提供变革性的解决方案，同时开辟人类健康的突破性新途径。
Understanding the Regenerative Mechanisms of Life
Regeneration is one of nature’s most remarkable phenomena, enabling organisms to repair and replace damaged tissues. This extraordinary capacity is widespread across the animal kingdom, yet the cellular and molecular foundations that govern organ regeneration remain poorly understood. Our research aims to unravel these fundamental mechanisms by investigating the dynamic processes that drive tissue repair and regeneration.
At the heart of our work is the use of innovative model systems that offer unparalleled insights into the genetic and environmental factors driving regenerative potential. By employing cutting-edge techniques such as functional genomics, spatial transcriptomics, single-cell RNA sequencing, and high-resolution imaging, we are mapping the intricate cellular landscapes that define regenerative biology across species. This interdisciplinary approach allows us to identify the core principles of regeneration that are conserved across different organisms.
We focus on both highly regenerative systems, like freshwater planarians, and those with limited regenerative capacity, such as the heart, to gain a comprehensive understanding of the regenerative process. Our research explores how different species harness their unique regenerative abilities, and how these insights can be translated to improve human regenerative therapies.
Our mission is to harness the power of regeneration to advance novel treatments for degenerative diseases, enhance tissue repair, and extend human longevity. By deepening our understanding of how organisms regenerate, we aim to not only revolutionize regenerative medicine but also contribute transformative solutions for cancer-related tissue damage, and pave the way for breakthroughs in human health.
