Zhu Y, Wang H, Yin F, Guo Y, Li F, Gao D, Qin J.  Amnion-on-a-chip: modeling human amniotic development in mid-gestation from pluripotent stem cells.  Lab Chip.   2020 Aug 26;20(17):3258-3268.   (PubMed Link)

Li F, Yuan QY, Di W, Xia XY, Liu Z, Mao NH, Li L, Li CF, He J, Li YG, Guo WX, Zhang XY, Zhu YQ, Aji R, Wang SQ, Chi P, Carver B, Wang Y*, Chen Y*, Gao D*.  ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming.  J Clin Invest.   2020 (in press).   (PubMed Link) (PDF)

Guo WX, Li L, He J, Liu Z, Han M, Li F, Xia XY, Zhang XY, Zhu Y, Wei Y, Li YG, Aji R, Dai H, Wei H, Li CF, Chen Y*, Chen LN*, Gao D* .  Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips.  Nature Genetics.   2020 Jul 23;137967.   (PubMed Link) (PDF)

Mao NH, Gao D, Hu WH, Gadal S, Hieronymus H, Wang SQ, Lee YS, Sullivan P, Zhang ZD, Choi D, Rosen N, Sawyers CL, Chen Y, Carver BS.  Oncogenic ERG represses PI3K signaling through down-regulation of IRS2.  Cancer Research.   2020 Apr 1;80(7):1428-1437.   (PubMed Link) (PDF)

He J, Zhang X, Xia XY, Han M, Li F, Li CF, Li YG, Gao D.  Organoid technology for tissue engineering.  J Mol Cell Biol.   2020 Apr 6:mjaa012.   (PubMed Link) (PDF)

Tang J, Wang HX, Huang XZ, Li F, Zhu H, Li Y, He LJ, Zhang H, Pu WJ, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Zhang L*, Gao D*, Zhou B*.  Sca1+ Vascular Stem Cells Contribute to Smooth Muscle for Artery Repair and Regeneration.  Cell Stem Cell.   2020 Jan 2;26(1):81-96.   (PubMed Link) (PDF)

Dhimolea E, Simoes R, Kansara D, Weng X, Sharma S, Awate P, Liu Z, Gao D, Mitsiades N, Schwab J, Chen Y, Jeselsohn R, Culhane A, Brown M, Georgakoudi I, Mitsiades C.  Pleiotropic mechanisms drive endocrine resistance in the three-dimensional bone microenvironment.  Cancer Research.   2020 (in press).   (PubMed Link)

Mao NH, Gao D, Hu WH, Hieronymus H, Wang SQ, Lee YS, Lee C, Choi D, Gopalan A, Chen Y, Carver BS.  Aberrant expression of ERG promotes resistance to combined PI3K and AR pathway inhibition through maintenance of AR target genes.  Molecular Cancer Therapeutics.   2019 Sep; 18:1577-1586.   (PubMed Link) (PDF)

Xia XY, Li F, He J, Aji R, Gao D.  Organoid technology in cancer precision medicine.  Cancer Letters.   2019 Aug 10;457:20-27.   (PubMed Link) (PDF)

Wang YT, Zhang J, Ren SX, Sun D, Huang HY, Wang H, Jin YJ, Li FM, Zheng C, Yang L, Deng L, Jiang ZJ, Jiang T, Han XK, Hou SD, Guo CC, Li F, Gao D, Qin J, Gao DM, Chen LN, Lin SH, Wong KK, Li C, Hu L, Zhou CC, Ji HB.  Wong KK, Li C, Hu L, Zhou CC, Ji HB. Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors..  Cell Reports.   2019 Jul 9;28:512-525.   (PubMed Link) (PDF)

Ding YF, Li N, Dong BJ, Guo WX, Wei H, Chen QL, Yuan HR, Han Y, Chang HW, Kan S, Wang XG, Pan Q, Wu P, Peng C, Qiu T, Li QT, Gao D*, Xue W*, Qin J*.  Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer.  J Clin Invest.   2019 Feb 1;129(2):759-773.   (PubMed Link) (PDF)

Zhang K, Zhang L, Liu W, Ma X, Cen J, Sun Z, Wang C, Feng S, Zhang Z, Yue L, Sun L, Zhu Z, Chen X, Feng A, Wu J, Jiang Z, Li P, Cheng X, Gao D, Peng L, Hui L.  In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity.  Cell Stem Cell.   2018 Dec 6;23(6):806-819.e4.   (PubMed Link) (PDF)

Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL.  PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells.  Cancer Discovery.   2018 Jul;8(7):866-883.   (PubMed Link) (PDF)

PUCA L, Bareja R, Prandi, Shaw R, Benelli M, Karthaus W, Hess J, Sigouros M, Donoghue A, Kossai M, Gao D, Cyrta J, Sailer V, Vosoughi A, Pauli C, Churakova Y, Cheung C, Deonarine L, McNary T, Tagawa S, Nanus D, Mosquera JM, Sawyers CL, Chen Y, Inghirami G, Rao R, Grandori C, Elemento O, Sboner A, Demichelis F, Rubin M, and Beltran H.  Patient Derived Organoids to Model Rare Prostate Cancer Phenotypes.  Nature Communications.   2018 Jun 19;9(1):2404.   (PubMed Link) (PDF)

Xie Y, Cao Z, Wong EW, Guan Y, Ma W, Zhang JQ, Walczak EG, Murphy D, Ran L, Sirota I, Wang S, Shukla S, Gao D, Knott SR, Chang K, Leu J, Wongvipat J, Antonescu CR, Hannon G, Chi P, Chen Y.  COP1-DET1-ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.  J Clin Invest.   2018 Apr 2;128(4):1442-1457.   (PubMed Link) (PDF)

Wang SQ, Gao D, Chen Y.  The potential of organoids in urological cancer research.  Nature Reviews Urology.   2017 Jul;14(7):401-414.   (PubMed Link) (PDF)

Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Andrew J. Aguirre AJ, Viswanathan SR, Tamayo P, Yang WS, Rees MG, Chen SX, Boskovic ZV, Javaid S, Huang C, Wu XY, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Daniel A. Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR & Schreiber SL.  Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.  Nature.   2017 Jul 27;547(7664):453-457.   (PubMed Link) (PDF)

Li F, Gao D.  Organoid and its application in cancer research.  Chinese Journal of Cell Biology.   2017 May; 39(4): 394-400.   (PubMed Link) (PDF)

Blattner M, Liu D, Robinson BD, Huang D, Poliakov A, Gao D, Nataraj S, Deonarine LD, Augello MA, Sailer V, Ponnala L, Ittmann M, Chinnaiyan AM, Sboner A, Chen Y, Rubin MA*, Barbieri CE*.  SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling.  Cancer Cell.   2017 Mar 13;31(3):436-451.   (PubMed Link) (PDF)

Yang ZH, Peng YC, Gopalan A, Gao D, Chen Y, Joyner AL*.  Stromal Hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer.  Disease Models & Mechanisms.   2017 Jan 1;10(1):39-52.   (PubMed Link) (PDF)

Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J, Ku SY, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L, Beltran H, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL*.  SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer.  Science.   2017 Jan 6;355(6320):84-88.   (PubMed Link) (PDF)

Dardenne E, Beltran H, Benelli M, Gayvert K, Berger A, Puca L, Cyrta J, Sboner A, Noorzad Z, MacDonald T, Cheung C, Gao D, Chen Y, Eilers M, Mosquera JM, Robinson BD, Elemento O, Rubin MA.  Francesca Demichelis F and Rickman DS. N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer.  Cancer Cell.   2016 Oct; 30:563-577.   (PubMed Link) (PDF)

Gao D*, Zhan Y, Di W, Moore AR, Sher JJ, Guan YX, Wang SQ, Zhang ZD, Murphy DA, Sawyers CL, Chi P and Chen Y*.   A Tmprss2-CreERT2 knock-in mouse model for cancer genetic studies on prostate and colon.  PLoS One.   2016 Aug 18;11(8):e0161084.   (PubMed Link) (PDF)

Drost J, Karthaus WR, Gao D, Driehuis E, Sawyers CL, Chen Y and Clevers H.  Organoid culture systems for prostate epithelial tissue and prostate cancer tissue.  Nature Protocols.   2016 Feb;11(2):347-58.   (PubMed Link) (PDF)

Wiesner T, Lee W, Obenauf A, Ran L, Murali R, Zhang Q, Wong E, Hu W, Sasinya S, Shah R, Scott S, Sboner A, Button J, Landa I, Gao D, Cao Z, Shukla S, , Merghoub T, Schwartz G, Wang L, Ladanyi M, Fagin J, Hollmann T, Busam K, BergerM , Chen Y and Chi P.  Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.  Nature.   2015 Oct 15;526(7573):453-7.   (PubMed Link) (PDF)

Ran LL, Sirota I, Cao Z, Murphy D, Chen YD, Shukla S, Xie YY, Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, Besmer P, Antonescu CR, Chen Y, Chi P.  Combined inhibition of MAP kinase and KIT signaling pathways destabilizes the ETV1 protein and synergistically suppress GIST tumorigenesis.  Cancer Discovery.   2015 Mar;5(3):304-15.   (PubMed Link) (PDF)

Gao D and Chen Y.  Organoid Development in Cancer Genome Discovery.  Current Opinion in Genetics and Development.   2015 Mar 18; 30:42-48.   (PubMed Link) (PDF)

Gao D, Vela I, Sboner A, Iaquinta PJ, Karthaus WL, Gopalan A, Wanjala JN, Dowling C, Undvall EA, Wongvipat J, Kossai M, Barboza LP, Di W, Cao Z, Zhang QF, Sirota I, Ran Ll, Solomon SB, MacDonald TY, Beltran H, Mosquera J, Eastham JA, Touijer KA, Scardino PT, Laudone VP, Rathkopf DE, Morris MJ, Danila DC, Slovin SF, Chi P, Clevers H, Carver B, Rubin MA, Scher HI, Sawyers CL, Chen Y.  Generation of in vitro organoids cultures derived from patients with advanced prostate cancer.  Cell.   2014 Sep; 159: 176-187.   (PubMed Link) (PDF)

Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, Wongvipat J, Gao D, Befthel H, Sachs N, Vries RG.J, Cuppen E, Chen Y, Sawyers CL and Clevers H.  Identification of multipotent luminal progenitor cells in human prostate organoid cultures.  Cell.   2014 Sep; 159: 163-175.   (PubMed Link) (PDF)

Zeng Y, Gao D, Kim JJ, Shiraishi T, Terada N, Kakehi Y, Kong CZ, Getzenberg RH, Kulkarni P.  Prostate-associated gene 4 (PAGE4) protects cells against stress by elevating p21 and suppressing reactive oxygen species production.  American Journal of Clinical and Experimental Urology.   2013 Dec; 1(1):39-52.11.   (PubMed Link) (PDF)

Chen Y, Chi P, Rockowitz S, Iaquinta P.J, Shamu T, Shukla S, Gao D, Sirota I, Carver B.S, Wongvipat J, Scher H.I, Zheng D, Sawyers CL.  ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.  Nature Medicine.   2013 Aug; 19(8):1023-9. 11.   (PubMed Link) (PDF)

Zeng Y, Wodzenski D, Gao D, Shiraishi T, Terada N, Li Y, Griend D.J.V, Luo J, Kong C, Getzenberg R.H, Kulkarni P.  Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing.  Cancer Research.   2013 Jul; 73(13): 4123-4133. 11.   (PubMed Link) (PDF)

Yang YK, Qu H, Gao D, Zhai ZH, and Chen DY.  ARF-like protein 16(ARL16) inhibits RIG-I by binding with CTD in GTP dependent manner.  J Biol Chem.   2011, 286: 10568-10580.11.   (PubMed Link) (PDF)

Gao D, Yang YK, Wang RP, Zhou X, Diao FC, Li MD, Zhai ZH, Jiang ZF, and Chen DY.  REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I.  PLoS One.   2009; 4(6):e5760.11.   (PubMed Link) (PDF)

Gao D, Wang RP, Li B, Yang Y, Zhai ZH, and Chen DY.  WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.  Cell Mol Life Sci.   2009; 6615:2573-84.   (PubMed Link) (PDF)

Zhang M, Wang RP, Diao FC, Lu F, Gao D, Chen D, Zhai ZH, and Shu HB.  A CXXC ring finger protein is required for DNA damage-induced p53 activation.  Science in China Series C: Life Science.   2009; 52(6):528-538.   (PubMed Link) (PDF)

Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, and Shu HB.  Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.  Cell Research.   2008 Nov; 18(11):1096-104.   (PubMed Link) (PDF)