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Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
CHEN Degui
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: cdchen@@sibcb.ac.cn

Research Areas
histone demethylases; epigenetics; embryonic stem cell; prostate cancer

Research Interests
My laboratory is currently interested in identification and characterization of histone demethylases. Through bioinformatic and biochemical analysis, we have identified several histone demethylases and hope to identify more of these enzymes that can specifically remove methyl groups from histones. By using different cell model systems, such as stem cell differentiation and prostate cancer cell models, we hope to reveal their roles in these processes. We will also use mouse genetic models to further characterize other biological functions of these enzymes.

Selected Publications

  1. Chengyang Huang, Yang Xiang, Yanru Wang, Xia Li, Longyong Xu, Ziqi Zhu, Ting Zhang, Qingqing Zhu, Kejing Zhang, Naihe Jing, and Charlie Degui Chen. Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Res. (2010) 20,154-165.
  2. Ziqi Zhu, Yanru Wang, Xia Li, Yiqin Wang, Longyong Xu, Xiang Wang, Tianliang Sun, Xiaobin Dong, Lulu Chen, Hailei Mao, Yi Yu, Jingsong Li, Pin Adele Chen, Charlie Degui Chen. PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis. Cell Res. (2010) 20,794-801.
  3. Hanqing Lin, Yiqin Wang, Yanru Wang, Feng Tian, Pu Pu, Yi Yu, Hailei Mao, Ying Yang, Ping Wang, Lulu Hu, Yan Lin, Yi Liu, Yanhui Xu, Charlie Degui Chen. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res. (2010) 20,899-907.
  4. Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen C, Higano CS, Beer TM, Hung DT, Scher HI, Jung M, Sawyers CL. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009 324:787-90.
  5. Mao M, Zhu Z, Chen CD*. The androgen receptor in hormone refractory prostate cancner. Asian Journal of Andrology 2009 11:69-73. Invited review.
  6. Yang Xiang, Ziqi Zhu, Gang Han, Xiaolei Ye, Bo Xu, Zhouchun Peng, Yuanjun Ma, Yi Yu, Hanqing Lin, Adele Pin Chen, Charlie Degui Chen. JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc Natl Acad Sci USA. 2007 104 (49):19226-19231. Corresponding author.
  7. Yang Xiang, Ziqi Zhu, Gang Han, Hanqing Lin, Longyong Xu and Charlie Degui Chen. JMJD3 is a histone H3K27 demethylase. Cell Research. 2007 17(10):850-857. Corresponding author.
  8. Mehrian-Shai R*, Chen CD*, Shi T, Horvath S, Nelson SF, Reichardt JKV, Sawyers CL. Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer. Proc Natl Acad Sci USA. 2007; 104(13): 5563-5568. Co-first author and co-corresponding author.
  9. Baek SH, Ohgi KA, Nelson CA, Welsbie D, Chen C, Sawyers CL, Rose DW, and Rosenfeld MG. Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells. PNAS 2006 103(9):3100-3105.
  10. Kim JH, Kim B, Cai L, Choi HJ, Ohgi KA, Tran C, Chen C, chung CH, Huber O, Rose DW, Sawyers CL, Rosenfeld MG, and Baek SH. Transcriptional regulation of a metastasis suppressor gene by Tip60 and b-catenin complexes. Nature 2005 434(7035):921-926.
  11. Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, Vessella R, Rosenfeld MG, Sawyers CL. Molecuar determinants of resistance to antiandrogen therapy. Nature Medicine, 2004; 10(1): 33-39.
  1. Chen CD, Sawyers CL. Molecular signature of the PTEN tumor suppressor. US application serial no. 60/530.101, 2003. WO2005059109, EP1709152, CA2550893, AU2004298604.
  2. Sawyers CL, Chen CD, Welsbie DS. Methods and materials for assessing prostate cancer therapies. US application serial no. 60/531.091, 2003. WO2005060661, EP1709193, CA2550447, AU2004305075.
  3. Jung ME, Ouk S, Sawyers CL, Chen CD, Welsbie DS. Methods and materials for assessing prostate cancer therapies and compounds. US2007191443, WO2005099693, AU2005232526.
  4. Sawyers CL, Jung ME, Chen CD, Ouk S, Welsbie DS, Tran C, Wongvipat J, Yoo D. Diarylhydantoin compunds. US application serial no.60/563.092, 2005. US6087509. WO2006124118.

Education Background & Academic Experience
2006-Now Principal Investigator, Institute of Biochemistry and Cell Biology, SIBS, CAS
2002-2005 Assitant Professor, University of California at Los Angeles
1999-2002 Postdoctor, Howard Hughes Medical Institute, University of California at Los Angeles
1995-1998 PhD. Cold Spring Harbor Laboratory and The State University of New York at Stony Brook, joint program for Molecular Biology and Biochemistry
1993-1995 MS. The State University of New York at Buffalo, Biochemistry
1985-1988 MS. Fujian Teachers University, Biochemistry
1981-1985 BS. Fujian Teachers University, Biochemistry

Research Team


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