Home CAS Center for Excellence


Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
CHEN Jiangye
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: jychen@@sibcb.ac.cn

Research Areas
Candida albicans; morphogenesis; hyphal development & virulence; white-opaque switching; gene regulation, NuA4 complex, Swi/Snf complex; Wor1; Flo8; MAPK; cAMP/PKA

Research Interests
C. albicans is one of the most frequently isolated opportunistic fungal pathogens in human. Our research interests have been: (1) functional study of genes involved in morphological transition of C. albicans, (2) transcription factors and chromatin remodeling complex for hyphal development and virulence in C. albicans, (3) signaling pathways in morphogenesis and pathogenesis of C. albicans, (4) the fine regulatory network in C. albicans morphogenesis and pathogenesis responding to different environmental cues and (5) study of the interactions between C. albicans and human host cells.

Selected Publications

  1. Minghui Yan, Xinyi Nie, Huafeng Wang, Ning Gao, Haoping Liu and Jiangye Chen*, Sumoylation of Wor1 by a novel SUMO E3 ligase controls cell fate in Candida albicans. Mol Microbiol. 2015 Jun 25. doi: 10.1111.
  2. Peng Chang, Xueyi Fan and Jiangye Chen*, Function and subcellular localization of Gcn5, a histone acetyltransferase in Candida albicans. Fungal Genet Biol. 2015 Feb 3. doi: 10.1016.
  3. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H*, Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015 Jun; 16(6): 642-52.
  4. Shicheng Zhang, Tianlong Zhang, Minghui Yan, Jianping Ding* and Jiangye Chen*, Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans. Cell Res. 2014; 24(9):1108-20.
  5. Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, Jianping Ding* Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5. Elife. 2014; 3. doi: 10.7554/eLife.02687.
  6. Zhe Zhang, Shanshan Wang, Tong Shen, Jiangye Chen, and Jianping Ding,*Crystal Structure of the Rab9A-RUTBC2 RBD Complex Reveals the Molecular Basis for the Binding Specificity of Rab9A with RUTBC2. Structure. 2014; 22(10): 1408-20.
  7. Shan Li, Wei Song, Mei Jiang, Liyong Zeng, Xueliang Zhu, Jiangye Chen*, Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation. FEBS Letters, 2014; 588 (11): 1989-96.
  8. Xiongjun Wang, Peng Chang, Jianping Ding and Jiangye Chen*, Distinct and Redundant Roles of the Two MYST Histone Acetyltransferases Esa1 and Sas2 in Cell Growth and Morphogenesis of Candida albicans. Eukaryot. Cell, 2013; 12 (3): 438-449.
  9. Wenji Song, HuafengWang and Jiangye Chen*, Candida albicans Sfl2, a temperature-induced transcriptional regulator, is required for virulence in a murine gastrointestinal infection model. FEMS Yeast Res, 2011, 11(2): 209-22.
  10. HuafengWang, Wenji Song, Guanghua Huang, Zhou Zhou, Yufeng Ding and Jiangye Chen*, Candida albicans Zcf37, a zinc finger protein, is required for stabilization of the white state. FEBS Letters, 2011, 585, 797C802.
  11. Xinyi Nie, Xiaoyan Liu, HuafengWang and Jiangye Chen*, Deletion of EFG1 promotes Candida albicans opaque formation responding to pH via Rim101. Acta Biochim Biophys Sin, 2010, 42, 735-744.
  12. Chang Su, Yandong Li, Yang Lu and Jiangye Chen*, Mss11, a Transcriptional Activator, is Required for Hyphal Development in Candida albicans. Eukaryot. Cell, 2009, 8 (11): 1780-1791.
  13. Mei Jiang, Yankun Gao, Tao Yang, Xueliang Zhu, Jiangye Chen*, Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. FEBS Letters, 2009, 583, 2171C2178.
  14. Yang Lu, Chang Su, Xuming Mao, Prashna Pala Raniga, Haoping Liu, and Jiangye Chen*. Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans. Mol. Biol. Cell. 2008, 19(10): 4260-4272.
  15. Xuming Mao, Yandong Li, Huafeng Wang, Fang Cao, Jiangye Chen*. Antagonistic Interplay of Swi1 and Tup1 on Filamentous Growth of Candida albicans. FEMS Microbiol Lett, 2008, 285: 233-241.
  16. Yandong Li, Chang Su, Xuming Mao, Fang Cao, and Jiangye Chen*. Roles of Candida albicans Sfl1 in Hyphal Development. Eukaryot. Cell, 2007, 6: 2112-2121.
  17. Xuming Mao, Fang Cao, Xinyi Nie, Haoping Liu, Jiangye Chen*. The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans. FEBS Letters, 2006, 580, 2615-2622.
  18. Yan-kun Gao, Mei Jiang, Tao Yang, Jiangye Chen*. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. Cell Res., 2006, 16, 539-547.
  19. Fang Cao, Shelley Lane, Prashna Pala Raniga, Yang Lu, Zhou Zhou, Karalyn Ramon, Jiangye Chen*, Haoping Liu*. The Flo8 Transcription Factor Is Essential for Hyphal Development and Virulence in Candida albicans. Mol Biol Cell. 2006; 17(1):295-307.
  20. Guanghua Huang, Huafeng Wang, Song Chou, Xinyi Nie, Jiangye Chen*, and Haoping Liu*. Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans. Proc Natl Acad Sci USA. 2006, 103, 12813-12818.

Education Background & Academic Experience

Prof. Jiangye Chen received her Ph.D. degree from Shanghai Institute of Biochemistry, CAS in 1988. From 1990 to 1992, studied at Dept. of Microbiology and Molecular Genetics, University of California at Irvine as a postdoctoral fellow. Was an associate Professor in Shanghai Institute of Biochemistry, CAS from 1992 to 1995 and a Professor from 1995 to 1999. She is now a Professor and group leader in Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, The research work is mainly on the molecular mechanisms of morphogenesis and pathogenesis of Candida albicans.

Research Team


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