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Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
PEI Gang
Ph.D., Professor
Member of CAS
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: gpei@@sibs.ac.cn

Research Areas
G protien coupled receptors; beta-arrestins; signaling regulation; protein interaction; epigenetic regulation; Alzheimer´s disease; diabetes; autoimmunity;

Research Interests
Our recent findings and reports from other groups demonstrate that ¶¬arrestin-mediated signalsomes and epigenetic regulation are of vital importance to GPCR-mediated signal transduction and consequent biological function of cells. Thus our future studies will focus on: 1. GPCR signaling and its cross-talk with other cellular signal pathways; 2. the epigenetic regulatory mechanisms of GPCR signaling and potential roles of GPCR signalsomes in important biological processes closely regulated by epigenetic events, including the development of embryonic stem cells, the reprogramming of somatic cells and etc.; 3. roles of GPCR signaling in the initiation, development, prevention and treatment of diseases, such as Alzheimer°Įs diseases, diabetes, and autoimmune disorders.

Selected Publications

  1. Cheng L, Hu W, Qiu B, Zhao J, Yu Y, Guan W, Yang W, Pei G. Generation of Neural Progenitor Cells by Chemical Cocktails and Hypoxia. Cell Res. 2014 Jun; 24(6):665-79
  2. Liu, X., Zhao, X., Zeng, X., Bossers K., Swaab D. F., Zhao J., and Pei, G. (2012). Beta-arrestin1 regulates ¶√-secretase complex assembly and modulates amyloid-¶¬ pathology. Cell Res. 2013 Mar; 23(3): 351-65.
  3. Zhuang LN, Hu WX, Xin SM, Zhao J, Pei G. {beta}arrestin1 represses adipogenesis and inflammatary responses through its interaction with PPAR{gamma}. J Biol Chem. 2011; 286, 28403-28413.
  4. Chen TT, Yuan DT, Wei B, Jiang J, Kang JH, Ling K, Gu Y, Li JS, Xiao L, Pei G.E-cadherin-Mediated Cell-Cell Contact is Critical for Induced Pluripotent Stem Cell Generation. Stem Cells.  2010;28:1315-25.
  5. Yue R, Kang JH, Zhao C, Hu WX, Liu XS, Tang YW, Pei G.¶¬-Arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell. 2009; 139:535-46.
  6. Du CS, Liu C, Kang JH, Zhao GX, Ye ZQ, Huang SC, Li ZX, Wu ZY, Pei G. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis.  Nat Immunol. 2009; 10:1252 ®C9.
  7. Luan B, Zhao J, Wu HY, Duan BY, Shu GW, Wang XY, Li DS£¨ Jia WP, Kang JH and Pei G. Deficiency of a barrestin2 signal complex contributes to insulin resistance. Nature. 2009; 457:1146-9.
  8. Shi YF, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L,Lu C, Zang JZ, Pei G. Critical regulation of CD4+ T cell survival and autoimmunity by ¶¬-arrestin 1. Nat Immunol. 2007; 8:817-24.
  9. Ni YX, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G. Activation of ¶¬2-adrenergic receptor stimulates g-secretase activity and accelerates amyloid plaque formation. Nat Med. 2006; 12:1390-6.
  10. Kang JH, Shi YF, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G, and Ma L. A Nuclear Function of b-Arrestin1in GPCR Signaling: Regulation of Histone Acetylation and Gene Transcription. Cell. 2005; 123:833-47.

Education Background & Academic Experience
Professor Gang Pei, graduated from Shenyang College of Pharmacy with a B.S. in 1981 and a M.S. in 1984, went to Karolinska Institute in Sweden as a visiting scholar in 1986, and pursued his Ph.D. study in University of North Carolina at Chapel Hill in USA during 1987-1991. After receiving his Ph.D. degree in Biochemistry and Biophysics in 1991, he continued his postdoctoral research in Howard Hughes Medical Institute, Duke University Medical Center till 1995. Then he came back to Shanghai Institute of Cell Biology. Professor Pei was elected as a member of Chinese Academy of Sciences in 1999, and a member of Third World Academy of Sciences in 2002. He is the current president of Chinese Society of Cell Biology and the president of Shanghai Institutes for Biological Sciences. He has been working on signal transduction of G protein-coupled receptors and its regulation since 1991, and has made some significant contributions in this area. Especially in the last few years, he and his group have revealed some important molecular, cellular, and neural mechanisms underlying the opiate drug addiction, and the cross-talking between different signaling pathways. Recently, they also discover a novel function of ¶¬-arrestin 1 as a cytoplasm-nucleus messenger in GPCR signaling and further elucidate an epigenetic mechanism for direct GPCR signaling from cell membrane to the nucleus through signal-dependent histone modification. His research group in the last 10 years has published more than 80 research papers at international journals.

Research Team


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