Home CAS Center for Excellence


Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
LIU Xinyuan
Member of CAS
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: xyliu@@sibcb.ac.cn

Research Areas
cancer(the most important keyword); super Interferon therapy; targeting gene-viroTherapy; oncolytic virus; gene therapy; targeting cancer stem cell therapy; organ specific cancer therapy

Research Interests
Our major interest and our aim is to cure the cancer patients and also to control the viral disease especial the hepatitis B or C disease. It is possible because that we have a super interferon by which the therapeutic effect for hepatitis B in clinic has reached 62% and hope to be more higher, while the regular protocol for hepatitis B disease treatment is about 30%.
        For cancer therapy, super interferon has rescued many cancer patients. In experimental mice model, the targeting dual gene-virotherapy can eliminate all the xenograft tumor in many diverse cancers. Therefore it is possible for us to complete our aim.

Selected Publications

1. Zi-fei Pei, Liang Chu, Weiguo Zou, Zilai Zhang, Songbo Qiu, Rong Qi, Jinfa Gu, Cheng Qian, Xin Yuan Liu (2004) Tumor Specific Targeting Adenovirus Mediates Smac to Augment the Antitumor Activity of TRAIL in Human Hepatoma. Hepatology, 39(5): 1371-1381.
2. Wei-guo Zou, Chunxia Luo, Zilai Zhang, Jing Liu, Jingfa Gu, Zifei Pei, Cheng Qian,, Xin Yuan Liu (2004) A Novel Oncolytic Adenovirus Targeting to Telomerase Activity in Tumor Cells with Potent. Oncogene, 23(2): 457-464.
3. Xin Yuan Liu, Songbo Qiu, Weiguo Zou, Zifei Pei, Jinfa Gu, Chunxia Luo, Hongmei Ruan, Yu Chen, Yipeng Qi* and Cheng Qian (2005) Effective Gene-Virotherapy for Complete Eradication of Tumor Mediated by the Combination of hTRAIL (TNFSF10) and Plasminogen k5. Mol. Therapy, 11(4): 531-541.
4. Yanhong Zhang, Jinfa Gu, Lili Zhao, Lingfeng He, Wenbin Qian, Jinhui Wang, Yigang Wang, Qijun Qian, Cheng Qian, Jian Wu and Xin Yuan Liu (2006)  Completely Elimination of Colorectal Tumor Xenograft by Combined Manganese Superoxide Dismutase with Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Gene Therapy. Cancer Research (HighlightPaper), 66(8): 4291-4298
5. Zhenwei Zhang, Yangbin Huang, Kam Newman, Jinfa Gu, Xuemei Zhang, Hua Wu, Ming Zhao, Zhiqun Xianyu, Xin Yuan Liu (2009) Reexpression of Human Somatostatin Receptor Gene 2 Gene Mediated by Oncolytic Adenovirus Increases Antitumor Activity of Tumor Necrosis FactorCRelated Apoptosis-Inducing Ligand against Pancreatic Cancer. Clinical Cancer Research, 15(16): 5154-60.

Education Background & Academic Experience
Xin-yuan Liu, Molecular Biologist, was born on November 1927 in Hunan Province, China. He graduated from Department of Chemistry, Nankai University in 1952, then worked in Hebei medical school from 1952-1957, completed his master thesis from 1960-1963 at Shanghai Institute of Biochemistry (SIB), Chinese Academy of Sciences (CAS), and was assigned to work in this institute till 2000.He went to USA and worked as a visiting scientist in Roche Institute of Molecular Biology in 1983-1984. From 2000-date, he worked in the Institute of Biochemistry and Cell Biology, CAS. He was promoted as associate professor in 1979, as full professor in 1985 and as a supervisor for PhD student in the same year. Now about 50 master and PhD student have been graduated from his lab. He has published more than 280 papers and compiled 8 volumes of Xin-yuan Liu¨s collected papers and got more than 30 times different awards, among them, there are many first or second class award, therefore, he was elected as an Academician of Chinese Academy of Science in 1992, as a Foreign Academician of National Academy of Ukraine in 1992, as an Academician of The Third World Academy of Science in 2001. Now he has been laureated three Academicians.

Research Team


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