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XIAO Lei
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Tel: 54921386 Email: xiaolab@sibs.ac.cn |
Research Interests
1. iPS cell technology.
Human iPS cells should be useful for studying the mechanisms of somatic cell reprogramming, the generation of patient-specific stem cell lines for studying various disease mechanisms and eventual transplantation therapies. We are focusing to improve the technology to eliminate the genomic integration of the virus vector.
2. Human embryonic stem cells (hESCs) self-renew indefinitely while maintaining pluripotency. The molecular mechanism underlying hESCs self-renewal and pluripotency is poorly understood. Our lab is planning to analyze the function of different signal pathways in maintaining the stemness of human embryonic stem cells. The signal pathways we are going to check include Wnt, BMP, FGF, TGF-beta, et al.. We expect that our study will provide more information about how the stemness is maintained in human ES cells.
3. Differentiate human embryonic stem cells into desired tissue cells. Methods should be established to differentiate human ES cells into specific lineages for transplantation therapy in the future, e.g. hematopoietic stem cells, insulin secreted pancreas beta cells, liver cells, et. al.. Our lab is planning to establish the differentiation protocol which will facilitate the study of human embryonic stem cells.
Selected Publications
- Zhao Wu*, Jijun Chen*, Jiangtao Ren, Lei Bao, Jing Liao, Chun Cui, Linjun Rao, Hui Li, Yijun Gu, Huiming Dai, Hui Zhu, Xiaokun Teng, Lu Cheng, Lei Xiao. (2009) Generation of Pig-Induced Pluripotent Stem Cells with a Drug-Inducible System. J Mol Cell Biol. * Joint first author.
- Lu Cheng, Lei Xiao. * (2009) Pig induced pluripotent stem cells: a new resource for generating gnetically modified pigs. Regenerative Medicine. 4(6):787-9.
- Jing Liao*, Chun Cui*, Siye Chen, Jiangtao Ren, Jijun Chen, Yuan Gao, Hui Li, Nannan Jia, Lu Cheng, Huasheng Xiao, and Lei Xiao. (2009) Generation of induced pluripotent stem cell lines from adult rat cells. Cell Stem Cell. 4(1):11-15. * Joint first author.
- Chun Cui, Lingjun Rao, Linzhao Cheng & Lei Xiao. Generation and application of human iPS cells. (2009) Chinese Science Bulletin. 54, 9-13.
- Zhao Wu*, Wei Zhang*, Guibin Chen, Lu Cheng, Jing Liao, Nannan Jia, Yuan Gao, Huiming Dai, Jinduo Yuan, Linzhao Cheng, and Lei Xiao. (2008) Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. J Biol Chem. 283, 24991-25002. * Joint first author.
- Jing Liao*, Zhao Wu*, Ying Wang, Lu Cheng, Chun Cui, Yuan Gao, Taotao Chen, Lingjun Rao, Siye Chen,Nannan Jia, Huiming Dai, Shunmei Xin, Jiuhong Kang, Gang Pei, Lei Xiao. (2008) Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors. Cell Res. 18, 600-603. * Joint first author.
- Xiao, L., Yuan, X., and Sharkis, S. J. (2006) Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells. 24, 1476-1486.
- Fan, G.*, Xiao, L.*, Cheng, L., Wang, X., Sun, B., and Hu, G. (2000) Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice. FEBS Lett. 467, 7-11. * Joint first author.
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Education Background & Academic Experience
Education and Training:
September 1991-July 1995: Department of Biology, Wuhan University, China, Bachelor of Science.
September 1997-July 2000: Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Ph.D. candidate.
September 2000-July 2003: Department of Molecular Biology, Adolf Butenandt Institute, Munich University, Germany. Ph.D. candidate. Ph. D.
October 2003-September 2005: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Cancer Biology, School of Medicine, John Hopkins University. Postdoctor fellow.
Research Experience:
September 1997-July 2000: Max-Planck Guest Lab, Shanghai Institute of Cell Biology, Chinese Academy of Sciences. PhD student.
September 2000-September 2003: Department of Molecular Biology, Adolf Butenandt Institute, Munich University, PhD student.
October 2003- September 2005: Department of Cancer Biology, School of Medicine, Johns Hopkins University. Postdoctor fellow.
October 2005-Present: Shanghai Institute of Biochemistry and Cell Biology. Principal Investigator.
January 2007-Present: Cell Bank/Stem Cell Bank of Chinese Academy of Sciences. Shanghai Institute for Biological Sciences. Director.
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