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Faculty

Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
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Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
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Principal Investigators
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WANG Gang
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: gwang@@sibcb.ac.cn

Research Areas
Signaling and gene regulation of cancer and stem cells; Mediator complex

Research Interests
Mediator complex was originally identified as a molecular bridge between activators and Pol II required for activation in vitro and in vivo. Our previous research demonstrated that, 1) The major form of the cellular Mediator Complexes are the large (>1.5 MD) Mediator Complexes with some hereogeneity, distinguished by the presence or absence of the CDK8/cyclin C submodule; 2) Adenovirus large E1A protein interacts with Mediator in vivo during adenoviral infection and transformation; 3) Mediator Med23 (Sur2) forms a Mediator submodule with two other subunits, Med16 and Med24; and 4) In addition to the simplistic "recruitment" role for promoting preinitiation complex (PIC) formation, Mediator also function at a post-recruitment step to stimulate transcription. My future research will combine the approaches of protein biochemistry, molecular biology, and genomics/proteomics to further analyze the functional relationship of Mediator to other molecular and cellular events, such as the coupling of the signal transduction and gene expression, chromosomal modification and remodeling, cell growth and differentiation, and cancer development.

Selected Publications

  1. Zhen Liu, Xiao Yao, Guang Yan, Yichi Xu, Jun Yan, Weiguo Zou*, Gang Wang*. Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nat Commun. 2016; 7:11149.
  2. Xiao Yao, Zhanyun Tang, Jingwen Yin, Yan Liang, Xing Fu, Robert G. Roeder, Gang Wang*. The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J. 2015, 34(23):2885-902. (Cover story with commentary)
  3. Wanqu Zhu, Xiao Yao, Yan Liang, Dan Liang, Lu Song, Naihe Jing, Jinsong Li, Gang Wang*. Mediator Med23-deficiency Enhances Neural Differentiation of Embryonic Stem Cells through Modulating BMP Signaling. Development. 2015; 142(3):465-76.
  4. Yan Huang, Xiao Yao, and Gang Wang*. ¡®Mediator-ing¡¯ messenger RNA processing. WIREs RNA. 2015; 6(2):257-269. (Invited review)
  5. Yang Sun, Xiaoyan Zhu, Xufeng Chen, Haifeng Liu, Yu Xu, Yajing Chu, Gang Wang*, Xiaolong Liu*. The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity. Nat Communs. 2014; 5:5225.
  6. Jingwen Yin, and Gang Wang*. The Mediator complex: a master coordinator of transcription and cell lineage development. Development. 2014; 141:977-987. (invited review)
  7. Yajing Chu, Leonardo Gomez Rosso, Ping Huang, Zhichao Wang, Yichi Xu, Xiao Yao, Menghan Bao, Jun Yan, Haiyun Song, Gang Wang*. Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Cell Res. 2014; 24:1250-1265.
  8. Yong Yu, Dan Liang, Qing Tian, Xiaona Chen, Bo Jiang, Binkuan Chou, Ping Hu, Linzhao Cheng, Ping Gao, Jinsong Li, Gang Wang*. Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis. Stem Cells. 2014; 32:349-363.
  9. Wei Wang, Xiao Yao, Yan Huang, Xiangming Hu, Runzhong Liu, DongmingHou, Ruichuan Chen, Gang Wang*. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. Transcription. 2013; 4(1):39-51.
  10. Bo Jiang, Hongyan Dong, Qingpeng Li, Yong Yu, Zhifeng Zhang, Yazhou Zhang, Gang Wang* and Zhongming Zhang*. Differentiation of Reprogrammed Mouse Cardiac Fibroblasts into Functional Cardiomyocytes. Cell Biochem Biophys. 2013; 66(2):309-18.
  11. Meng Zhao, Xu Yang, Yu Fu, Haifang Wang, Yuanheng Ning, Jun Yan, Yeguang Chen, and Gang Wang*. Mediator MED15 modulates transforming growth factor beta (TGF¦Â)/Smad signaling and breast cancer cell metastasis. JMCB. 2013; 5(1):57-60.
  12. Yuting Liu, Wenchao Hu, Yasuhiro Murakawa, Jingwen Yin, Gang Wang, Markus Landthaler, Yan, Jun. Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation. Sci Rep. 2013; 3:2054.
  13. Jingwen Yin, Yan Liang, JiYeon Park, Dongrui Chen, Xiao Yao, Qi Xiao, Zhen Liu, Bo Jiang, Yu Fu, Menghan Bao, Yan Huang, Yuting Liu, Jun Yan, Minsheng Zhu, Zhongzhou Yang, Pingjin Gao, Bin Tian, Dangsheng Li, Gang Wang*. The Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes & Dev. 2012; 26(19):2192-2205. Highlighted by Nature Asia ¨C AIMBN.
  14. Xu Yang, Meng Zhao, Min Xia, Yuting Liu, Jun Yan, HongbinJi, and Gang Wang*. Selective Requirement for Mediator MED23 in Ras-active Lung Cancer. PNAS. 2012; 109(41):E2813-22. Highlighted by Nature Asia ¨C AIMBN.
  15. Yan Huang, Wencheng Li, Xiao Yao, Qijiang Lin, Jingwen Yin, Yan Liang, Monika Heiner, Bin Tian, Jingyi Hui, and Gang Wang*. Mediator Complex Regulates Alternative mRNA Processing via the MED23 Subunit. Mol Cell. 2012; 45:459-469. Cover story with commentary; Highlighted in Faculty 1000.
  16. Lei Lv, Dong Li, Di Zhao, Ruiting Lin, Yajing Chu, Heng Zhang, ZhengyuZha, Ying Liu, Zi Li, YanpingXu, Gang Wang, Yiran Huang, YueXiong, Kunliang Guan, and Qunying Lei*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Mol Cell. 2011; 42(6):719-730.
  17. Qian Chen, Xiaoyun Shi, Cornelia Rudolph, Yong Yu, Ding Zhang, Xiaoyu Zhao, Sabine Mai, Gang Wang, Brigitte Schlegelberger, Qinghua Shi*. Recurrent trisomy and Robertsonian translocation of chromosome 14 in murine iPS cell lines. Chromosome Res. 2011; 19:857-868.
  18. Wei Wang, Jingwen Yin, Aijie Liu, Gang Wang*. Mediator Complex--Central controller of eukaryotic transcription. Chinese Journal of Cell Biology. 2011; 33(6):597-607.
  19. Wei Wang, Lu Huang, Yan Huang, Jingwen Yin, Arnold J. Berk, Jeffrey Friedman, Gang Wang*. Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell. 2009; 16:764-771.
  20. Hui Geng, Gang Wang*. Unraveling the mystery of eukaryotic transcription¨Dcomment on 2006 Nobel Prize in Chemistry. Sci Journal (in chinese). 2007; 59(1):57-59.
  21. Gang Wang, Michael Balamotis, Jennitte Stevens, Yuki Yamaguchi, Hiroshi Handa, and Arnold J. Berk. Mediator requirement for both recruitment and post-recruitment steps in transcription initiation. Mol Cell. 2005; 17(5):683-694. Commentary; Highlighted in Faculty 1000.
  22. Gang Wang, and Arnold J. Berk. In vivo association of adenovirus large E1A protein with human Mediator complex in adenovirus-infected and -transformed cells. J. Virology. 2002; 76(18):9186-9193.
  23. Jennitte Stevens, Greg Cantin, Gang Wang, Andrej Shevchenko, Anna Shevchenko, Arnold J. Berk. Transcription control by E1A and ERK MAP kinase pathway through Sur2 Mediator subunit. Science. 2002; 296:755-758. Highlighted in Faculty 1000
  24. Gang Wang, Greg Cantin, Jennitte Stevens, and Arnold J. Berk. Characterization of Mediator Complexes from HeLa cell nuclear extract. Mol Cell Biol. 2001; 21:4604-4613.
  25. Zheng Shen, Gang Wang, and Shuzhi Lin. Two-way shuttlebox avoidance conditioning and brain NADH in Rats. Physiology & Behavior. 1990; 48:515-517.

Education Background & Academic Experience
Dr. Gang Wang received his B.S. in Psychology from Peking University in 1988, M.S. in Psychology from University of North Carolina in 1993, and Ph.D. in Molecular and Cellular Biology from Tulane University in 1998. From 1999 to 2005, he was a Postdoctoral fellow and then an Assistant Researcher in the Molecular Biology Institute at the University of California, Los Angeles. He was recruited to the Institute of Biochemistry and Cell Biology by the Chinese Academy of Science "Hundred Talent Program" in 2006.

Research Team

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