Home CAS Center for Excellence


Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
LI Yiping
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: yipingli@@sibcb.ac.cn

Research Areas
spermatozoa; GABA; GABAergic system; testis; acrosome reaction; zygotic gene activation (ZGA); mid-blastula transition (MBT); epigenetics; zebrafish; early embryonic development

Selected Publications

  1. Zheng HP, Du Y, Hua Y, Wu ZL, Yan YC, Li YP. Essential role of Fbxl14 ubiquitin ligase in regulation of vertebrate axis formation through modulating Mkp3 level. Cell Res 2012;22(5):936C940
  2. Hu SN, Yu H, Zhang YB, Wu ZL, Yan YC, Li YX, Li YY, Li YP*. Splice blocking of zygotic sox31 leads to developmental arrest shortly after Mid-Blastula Transition and induces apoptosis in zebrafish. FEBS Lett 2012;586(3):222C228.
  3. Cao JL, Shen YD, Zhu L, Xu YN, Zhou YZ, Wu ZL, Li YP, Yan XM, Zhu XL. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol 2012;14(7):697-706.
  4. Hu SN, Wu ZL, Yan YC, and Li YP*. Sox31 is involved in central nervous system anteroposterior regionalization through regulating the organizer activity in zebrafish. Acta Biochim Biophys Sin 2011;43(5):387C399
  5. Zheng HP, Li SF, Wu ZL, Zhang YB, Hu SN, Yan YC, Li YP*. Diferential response of multiple zebrafish hepatic F-box protein genes to 17α-ethinylestradiol treatment. J Environ Sci 2011;23(4):664C670
  6. Li SF, Liu HX, Zhang YB, Yan YC, Li YP*. The protective effects of alpha-ketoacids against oxidative stress on rat spermatozoa in vitro. Asian J Androl 2010;12(2):247-256.
  7. Sun C, Xu M, Xing Z, Wu Z, Li Y, Li T, Zhao M. Expression and function on embryonic development of lissencephaly-1 genes in zebrafish. Acta Biochim Biophys Sin 2009;41(8): 677-688.
  8. Liu H, Wang Z, Li S, Zhang Y, Yan YC, Li YP*. Utilization of an intron located polyadenlyation site resulted in four novel glutamate decarboxylase transcripts. Mol Biol Rep 2009;36(6):1469-1474.
  9. Lv W, Zhang Y, Wu Z, Chu L, Koide SS, Chen Y, Yan Y, Li Y*. Identification of wsb1 gene as an important regulator in the development of zebrafish embryo during midblastula transition. Acta Biochim Biophys Sin 2008;40(6):478-488.
  10. Li S, Zhang Y, Liu H, Yan Y, Li Y*. Identification and expression of gabac receptor in rat testis and spermatozoa. Acta Biochim Biophys Sin 2008;40(8):761-767.
  11. Gan XQ, Wang JY, Xi Y, Wu ZL, Li YP, Li L. Nuclear dvl, c-jun, beta-catenin, and tcf form a complex leading to stabilization of beta-catenin-tcf interaction. J Cell Biol 2008;180 (6):1087-1100.
  12. Ding Y, Xi Y, Chen T, Wang JY, Tao DL, Wu ZL, Li YP, Li C, Zeng R, Li L. Caprin-2 enhances canonical wnt signaling through regulating lrp5/6 phosphorylation. J Cell Biol 2008;182(5):865-872.
  13. Liu QY, Wu ZL, Lv WJ, Yan YC, Li YP*. Developmental expression of cyclin h and cdk7 in zebrafish: The essential role of cyclin h during early embryo development. Cell Res 2007; 17(2):163-173.
  14. Li SF, Hu JH, Yan YC, Chen YG, Koide SS, Li YP*. Identification and characterization of a novel splice variant of beta3 subunit of gaba(a) receptor in rat testis and spermatozoa. Int J Biochem Cell Biol 2005;37(2):350-360.
  15. Qiu JJ, Zhang WW, Wu ZL, Wang YH, Qian M, Li YP*. Delay of zga initiation occurred in 2-cell blocked mouse embryos. Cell Res 2003;13(3):179-185.
  16. He XB, Yan YC, Li YP*, Koide SS. Cloning of rat sp56, the homologue of mouse sperm zp3 receptor-sp56. Cell Res 2003;13(2):121-129.
  17. He X, Zhang Y, Yan Y, Li Y*, Koide SS. Identification of gababr2 in rat testis and sperm. J Reprod Dev 2003;49(5):397-402.

Education Background & Academic Experience
Yiping Li, Ph. D. Group leader, Received Ph. D. degree in Biochemistry from East China Normal University, in 1990 and followed by 2 years post-doctoral training in the department of molecular biology in Universit└ Libre de Bruxelles, Belgium. Was a group leader in Shanghai Institute of Cell Biology, Chinese Academy of Sciences from 1995 to 2000. During that period of time, he was also entitled head of research group, assistant director and deputy director of the institute successively. Having been on the current position since 2000.


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