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Faculty

Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
BAO Lan
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: baolan@@sibcb.ac.cn

Research Areas
receptor/ion channel trafficking; sodium channel; opioid receptor; neuropeptide; ER retention/retrival; large dense core vesicle; primary sensory sensation; pain

Research Interests
The proteins are transported to different subcellular areas to exhibit their functions after synthesis in cells. Neurons are highly specialized cells with axon and dendrites. Our group is interested in the molecular and cellular mechanisms of protein transport in neurons. One direction of research is exploring the mechanisms of receptor and ion channel transport and related significance in sensory sensation and pain modulation. Another direction is identifying the post-translational modifications of tubulins and their roles in neuronal development and neurodegenerative diseases.
Receptors and ion channels play an important roles in sensory transmission and modulation. The sorting, trafficking and localization of receptors and ion channels are precisely controlled in sensory neurons. We use the techniques of Molecule Biology, Cell Biology and Neurobiology to study the transport route of these membrane proteins in physiological and pathological (peripheral inflammation and nerve injury) conditions. Furthermore, we identify the localizing signals within receptors and ion channels, extracellular factors, interacting proteins and signaling pathways to regulate the localization and trafficking of these proteins. Our studies contribute to the basic theory of sorting and trafficking of receptors and ion channels, and also to the mechanisms of sensory sensation and pain.
In neurons, microtubule provides tracks for protein and vesicle transportation in cell body especially in axon and dendrite. Microtubule dynamics can be modulated by intracellular molecules and extracellular factors which leads to microtubule assembly and disassembly. During neuronal development, proper regulation of microtubule dynamics is essential for neurite outgrowth, neuronal polarity and migration. We identify the post-translational modifications to tubulin subunits, detect their effects on microtubule dynamics, explore their regulatory molecules and signaling pathways, and investigate their roles in neuronal development (neurite outgrowth, neuronal polarity and migration) and neurodegenerative diseases.

Selected Publications

  1. Wang B and Bao L*. (2017) Axonal microRNAs: localization, function and regulatory mechanism during axon development. J. Mol. Cell Biol., 9: 82-90.
  2. Yang L, Dong F, Yang Q, Yang PF, Wu R, Wu QF, Wu D, Li CL, Zhong YQ, Lu YJ, Cheng X, Xu FQ, Chen L, Bao L and Zhang X. (2017) FGF13 selectively regulates heat nociception by interacting with Nav1.7. Neuron, 93: 806-821.
  3. Wang B, Pan L, Wei M, Wang Q, Liu WW, Wang N, Jiang XY, Zhang X and Bao L*. (2015) FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting Map1b and Calm1Cell Reports, 13: 1-14.
  4. Chen XQ, Zhu JX, Wang Y, Zhang X and Bao L*. (2014) CaMKII and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor. J. Mol. Cell Biol., 6: 140-153.
  5. Su YY, Ye M, Li L, Liu C, Pan J, Liu WW, Jiang Y, Jiang XY, Zhang X, Shu Y and Bao L*. (2013) KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8. J. Neurosci., 33: 17884-17896.
  6. Han QJ, Gao NN, Ma GQ, Zhang ZN, Yu WH, Pan J, Wang Q, Zhang X and Bao L*. (2013) IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-/Smad signaling. J. Cell Sci., 126: 542-553.
  7. Li L, Wei D, Wang Q, Pan J, Liu R, Zhang X and Bao L*. (2012) MEC-17 deficiency leads to reduced -tubulin acetylation and impaired migration of cortical neurons. J. Neurosci., 32: 12673-12683.
  8. Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and Bao L*. (2012) Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res., 22: 677-696.
  9. Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L and Zhang X. (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell, 149:1549-1564.
  10. He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L* and Zhang X*. (2011) Facilitation of -opioid receptor activity by preventing -opioid receptor-mediated codegradation. Neuron, 69: 120-131.
  11. Li Q, Su YY, Wang H, Li L, Wang Q and Bao L*. (2010) Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation. J. Biol. Chem., 285: 32977-32987.
  12. Wang HB, Zhao B, Zhong YQ, Li KC, Li ZY, Wang Q, Lu YJ, Zhang ZN, He SQ, Zheng HC, Wu SX, Hökfelt TGM*, Bao L*, and Zhang X*. (2010) Coexpression of - and µ-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci U S A., 107: 13117-13122
  13. Liu C, Li Q, Su YY and Bao L* (2010) Prostaglandin E2 promotes Nav1.8 trafficking via its intracellular RRR motif through the protein kinase A pathway. Traffic, 11: 405-417.
  14. Zhang X*, Bao L* and Ma GQ (2010) Sorting of neuropeptides and neuropeptide receptors into secretory pathways. Progress in Neurobiology, 90: 276-283. (Review)
  15. Ma GQ, Wang B, Wang HB, Wang Q and Bao L* (2008) Short elements with charged amino acids form clusters to sort protachykinin into large dense-core vesicles. Traffic, 9: 2165C2179.
  16. Zhang ZN, Li Q, Liu C, Wang HB, Wang Q and Bao L* (2008) Voltage-gated sodium channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the 3 subunit. J. Cell Sci. 121: 3243-3252

Education Background & Academic Experience
Education:
August, 1980 Medical student, 4th Military Medical University (FMMU), Xian, P.R China
August, 1985 Bachelor of Medicine, FMMU, Xian, P.R. China
August, 1985 Graduate student, Department of Aerospace Physiology, FMMU, Xian, P.R. China
August, 1988 Master Degree of Medicine, FMMU, Xian, P.R. China
August, 1996 Graduate student, Department of Aerospace Physiology, FMMU, Xian, P.R. China
July, 1999 Doctor Degree of Medicine (M.D.), Department of Aerospace Physiology, FMMU, Xian, P.R. China
Academic experience:
September, 1988 Teaching assistant, Department of Aerospace Physiology, FMMU, Xian, P.R. China
September, 1990 Lecture, Department of Aerospace Physiology, FMMU, Xian, P.R. China
August, 1993 Guest scientist, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
August, 1994 Lecture, Department of Aerospace Physiology, FMMU, Xian, P.R. China
September, 1996 Associate Professor, Department of Aerospace Physiology, FMMU, Xian, P.R. China
November, 1999 Associate Professor, Laboratory of Sensory System, Institute of Neuroscience, Chinese Academy of Sciences, P.R. China
March, 2004 Professor and Principal Investigator, Group of Neuronal Protein Transport, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, P.R. China
Committee Member of Society:
Council Member, Chinese Society of Neuroscience
Council Member, Shanghai Society of Neuroscience
Committee Member of Cellular Neurobiology, Chinese Society of Cell Biology
Award:
1990 Fourth Award for Progress in Science and Technology of PLA (China)
1992 Third Award for Progress in Science and Technology of PLA (China)
1993 Third Award for Progress in Science and Technology of PLA (China)
1993 Second Award for Progress in Science and Technology of PLA (China)
1996 First Award for Progress in Science and Technology of PLA (China)
1996 Third Award for Progress in Science and Technology of China
2002 Program of Outstanding Young Scientist, Shanghai Institutes of Life Science, Chinese Academy of Sciences
2003 Fund for National Outstanding Young Scientists, National Nature Science Foundation of China
2004 Second Award for Progress in Science and Technology (Shanghai)
2008 100 Talents Program of The Chinese Academy of Sciences

Research Team

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