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Faculty

Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
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Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
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Principal Investigators
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SONG Jianguo
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: jgsong@@sibcb.ac.cn

Research Areas
epithelial-mesenchymal transition; Apoptosis; TGF-beta; Cell differentiation; Adipogenesis; Insulin receptor substrate-1; Nitric oxide; Ceramide; Protein kinase A; STAT3; secretory phospholipase A2; Ferritin heavy chain; Labile iron pool; Phospholipase; Lipid messenger

Research Interests
Cellular fates and functions are controlled by various signaling events orchestrated via complex signaling networks. EMT and apoptosis have been implicated in various physiological and pathological processes such as embryonic development, body homeostasis, fibrotic diseases of liver and lung, tumor progress and metastasis. We are interest in studying the mechanisms of cell death-survival and differentiation. The studies have been focused on the signaling mechanisms through which the cell EMT and apoptosis were regulated by TGF-¶¬1.
        The general questions we are attempting to answer include: 1. What biologically significant protein molecules are involved in TGF-¶¬1-mediated EMT and cell apoptosis, and what specific roles the molecules in question play in these events? 2. What signaling pathways are implicated in the control of EMT and cell apoptosis? 3. How are the different cellular responses in mouse hepatocytes (apoptosis and EMT) been elicited by TGF-¶¬. We are also interest in determining whether and how epigenetic regulation has been involved in the control of EMT and cell apoptosis. These studies may be of helpful in identifying and developing novel mechanism-based molecular targets for therapeutic application.

Selected Publications

  1. Liu Y, He K, Hu Y, Guo XJ, Wang DM, Shi WW, Li JS & Song JG. YAP modulates TGF-¶¬1-induced simultaneous apoptosis and EMT through upregulation of the EGF receptor. Scientific Reports, 20 April 2017.
  2. Wang DM, Shi WW, Tang YN, Liu Y, He K, Hu Y, Li JS, Yang YX, and Song JG. Prefoldin 1 promotes EMT and lung cancer progression through suppressing cyclin A expression. Oncogene, 2017,36:885®C98 (published online 3 October 2016).
  3. Yunneng Tang, Weiqiao Ding, Xiaojie Guo, Xinwang Yuan, Dongmei Wang, Jianguo Song* (2015) Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis. Nature Communication.
  4. Xinwang Yuan, Dongmei Wang, Ying Hu, Yunneng Tang, Weiwei Shi, Xiaojie Guo, Jianguo Song*(2013) Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition. J Biol Chem., 288, 31206-31216.
  5. Ying Hu, Kai He, Dongmei Wang, Xinwang Yuan, Yi Liu, Hongbin Ji, Jianguo Song*(2013) TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways. Carcinogenesis, 34, 1764-1772
  6. Guangwen Shu, Yunneng Tang, Yi Zhou, Chen Wang, Jianguo Song* (2011) Zac1 is a histone acetylation-regulated NF-¶ B suppressor that mediates histone deacetylase inhibitor-induced apoptosis. Cell Death and Differentiation, 18, 1825-1835..
  7. Yunneng Tang, Guangwen Shu, Xinwang Yuan, Naihe Jing, Jianguo Song*. (2011) FOXA2 functions as a suppressor for tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers. Cell Res., 21, 316®C326.
  8. Liang Zhang, Weiwei Lei, Xunde Wang, Yunneng Tang, Jianguo Song* (2010) Glucocorticoid induces mesenchymal-to-epithelial transition and inhibits TGF-¶¬1-induced epithelial-mesenchymal transition and cell migration. FEBS Lett., 584, 4646®C4654.
  9. Xunde Wang, Xinchao Pan, Jianguo Song* (2010). AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition. Cell Signal., 22, 1790-1797.
  10. Weiwei Lei, Kehua Zhang, Xinchao Pan, Dongmei Wang, Ying Hu, Yanan Yang, Jianguo Song* (2010). Histone deacetylase 1 and 2 differentially regulate apoptosis via opposing effects on extracellular signal-regulated kinase 1/2. Cell Death and Disease, 1, e44.
  11. Weiwei Lei, Kehua Zhang, Xinchao Pan, Ying Hu, Dongmei Wang, Xinwang Yuan, Guangwen Shu£¨Jianguo Song* (2010). Histone deacetylase 1 is required for transforming growth factor-¶¬1-induced epithelial-mesenchymal transition. Int J Biochem Cell Biol, 42, 1489-1497.
  12. Dongmei Wang, Yiran Zhou, Weiwei Lei, Kehua Zhang, Jian Shi, Ying Hu, Guangwen Shu, Jianguo Song* (2010). Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor ¶√ (PPAR¶√). Biology of the Cell, 102: 1-12.
  13. Hongyu Tian, Kehua Zhang, Xia Gao, Weiwei Lei, Liang Zhang, MeilanYu, Jianguo Song*, Fukun Zhao* (2009). Comparative proteomic analysis of cell cycle-dependent apoptosis induced by transforming growth factor-beta. Biochim Biophys Acta, 1794, 1387-1397.
  14. Xinchao Pan, Xunde Wang, Weiwei Lei, Lihua Min, Yanan Yang, Xin Wang and Jianguo Song*. (2009) Nitric oxide suppresses transforming growth factor-¶¬1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology, 50, 1577-1587.
  15. Jian Shi, Dongmei Wang, Chunmei Wang, Ying Hu, Aihua Liu, Yonglian Zhang, Bing Sun and Jianguo Song*. (2009) Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithelial®Cmesenchymal transition. Cancer Res., 69, 7180-7187.
  16. Kehua Zhang, Hongyu Tian, Xia Gao, Weiwei Lei, Ying Hu, Dongmei Wang, Xinchao Pan, Meilan Yu, Genjun Xu, Fukun Zhao and Jianguo Song*. (2009) Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesenchymal transition. Cancer Res., 69, 5340-5348.
  17. Kehua Zhang, Dongmei Wang and Jianguo Song* (2009). Cortactin is involved in transforming growth factor-¶¬1-induced epithelial-mesenchymal transition in AML-12 cells. Acta Biochimica et Biophysica Sinica, 41, 839-845.
  18. Fuqiang Li, Dongmei Wang, Yiran Zhou, Bo Zhou, Yanan Yang, Hehua Chen, and Jianguo Song* (2008). Protein kinase A suppresses the differentiation of 3T3-L1 preadipocytes. Cell Res., 18, 311-323.
  19. Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li and Jianguo Song*. (2006) Regulation of Transforming Growth Factor-B1®CInduced Apoptosis and Epithelial-to-Mesenchymal Transition by Protein Kinase and Signal Transducers and Activators of Transcription 3. Cancer Res., 66, 8617-8624.
  20. Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang and Jianguo Song*. (2006) Transforming growth factor-¶¬1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism. Oncogene, 23, 7235-7244.
  21. Yiran Zhou, Dongmei Wang, Fuqiang Li, Jian Shi and Jianguo Song*. (2006) Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation. Int. J. Biochem. Cell Biol., 38, 2151-2163.
  22. Bo Zhou, Fuqiang Li, Hehua Chen and Jianguo Song*. (2005) The modulation of apoptosis by cyclic AMP involves Akt and epidermal growth factor receptor. Int. J. Biochem. Cell Biol., 37, 1483-1495.
  23. Sheng Zhao, Yanan Yang and Jianguo Song*. (2004) Ceramide induces caspase-dependent and -independent apoptosis in A-431 cells. J. Cell Physiol., 199, 47-56.
  24. Yanan Yang, Sheng Zhao, and Jianguo Song*. (2004) Caspase-dependent apoptosis and -independent poly(ADP-ribose) polymerase cleavage induced by transforming growth factor-¶Ń1. Int. J. Biochem. Cell Biol., 36, 223-234.
  25. Hehua Chen, Sheng Zhao and Jianguo Song* (2003). TGF-¶Ń1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production. Cell Death and Differentiation. 10:320-331.
  26. Sheng Zhao, Xiaoyan Du, Junsong Chen, Yuancong Zhou, Jianguo Song* (2002). Secretory phospholipase A2 inhibits epidermal growth factor-induced receptor activation. Exp. Cell Res., 279, 354-365.
  27. Sheng Zhao, Xiaoyan Du, Minqiang Chai, Junsong Chen, Yuancong Zhou and Jianguo Song* (2002). Secretory phospholipase A2 induces apoptosis via a mechanism involving ceramide generation. BBA-Mol Biol Cell Lipids, 1581, 75-88.
  28. Minqiang Chai, Junsong Chen, Sheng Zhao, Jianguo Song* (2001). Propranolol increases phosphatidic acid level via phospholipase D activation. Acta Pharmacologica Sinica, 22 22, 777-784.
  29. Jinhui Liao, Junsong Chen, Minqiang Chai, Sheng Zhao, and Jianguo Song* (2001). The involvement of p38 MAPK in transforming growth factor beta 1-induced apoptosis in murine hepatocytes. Cell Res., 11, 89-94.
  30. Junsong Chen and Jianguo Song* (2001). Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells. IUBMB Life, 51:49-56.
  31. Binghong Zhou, Junsong Chen, Mingqiang Chai, Sheng Zhao, Jun Lian, Hehua Chen, and Jianguo Song* (2000). Activation of phospholipase D activity in transforming growth factor-beta-induced cell growth inhibition. Cell Res., 10,139-149.
  32. Junsong Chen, Minqiang Chai, Hehua Chen, Sheng Zhao and Jianguo Song* (2000). Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells. BBA-Mol Biol Cell Lipids, 1488, 219-232.

Education Background & Academic Experience
Jianguo Song, Principal investigator Received Ph.D. (Biochemistry) degree from the City University of New York (CUNY) in 1993. Completed the postdoctoral work in the University of California, San Francisco. Hold the current position since the beginning of 1996. Research field-Cellular signaling The cell proliferation, differentiation and apoptosis were tightly regulated processes. Our research work is currently focused on the signaling mechanisms, particularly on the mechanism of TGF-beta1-mediated effects in the above processes.

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