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Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
WU Jiarui
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: wujr@@sibs.ac.cn

Research Areas
cell cycle; system biology of complex diseases; cell differentiation & apoptosis; diabetes; adipogenesis; IGF-1 receptor; p53; Bcl-2; SARS; c-Myc

Research Interests
Systems Biology is defined as an integrating methodology for analyzing the components and dynamical behavior of biological complex systems as a whole. Based on the theory and approaches of systems biology, my Lab has concentrated on the structure and function of molecular networks for cell fate determination among cell differentiation, cell proliferation and apoptosis, particularly I would like to ask that how cells inter-regulate cell proliferation and differentiation, which is a key to understand the behaviors of stem cells and the development of multi-cellular organisms.
        Since the research strategy of systems biology is well fit to analyze the biological complex systems. I am applying this strategy on the mechanism of the complex diseases such as cancer and diabetes. My ongoing project is to identify biomarkers in order to detect the progress stages of the diabetes. As a metabolic disease, diabetes-related proteins tend to enter the circulation system, thus the biomarker discovery in plasma has the potential to play an important role in the early detection and treatment of diabetes. We have developed systematic approaches based on proteomics and bioinformatics to analyze human normal and diabetic serum. In addition, I have planed to analyze the genetic and environmental factors and their interactions during the progressing of the type 2 diabetes with systems-biology approaches.

Selected Publications

Selected Recent Publications:

1. RX Li, HB Chen, K Tu, SL Zhao, H Zhou, SJ Li, J Dai, QR Li, S Nie, YX Li, WP Jia*, R Zeng*, JR Wu* (2008) Localized-Statistical Quantification of Human Serum Proteome Associated with Type 2 Diabetes PLoS ONE 3:e3224
2. W Guo, KM Zhang, K Tu, YX Li, L Zhu, HS Xiao, Y Yang, JR Wu* (2009) Adipogenesis licensing and execution are disparately linked to cell proliferation Cell Res. 19:216-223
3. Jianhua Zhang, Ying Yang and Jiarui Wu* (2010) Palmitate impairs cytokinesis associated with RhoA inhibition Cell Res 20: 492-494
4. Shuai Han ,Heling Pan£¬Jianhua Zhang£¬Li Tan£¬Dawei Ma£¬JunyingYuan * and Jiarui Wu*. (2010) Identification of a small molecule activator of novel PKCs for promoting glucose-dependent insulin secretion. Cell Res, in print
5. Kunming Zhang, Wei Guo, Ying Yang and Jiarui Wu* (2010) JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPß transcription. J. Cell. Biochem. In print
6. Hongjuan Pei ,Yao Yao, Ying Yang, Kan Liao* and Jiarui Wu*.  Kr¨¹ppel-like factor KLF9 regulates PPARgamma transactivation at the middle stage of adipogenesis. Cell Death Differ, 2010, in print
7. Zhi Liang, Meng Xu, Maikun Teng, Liwen Niu, Jiarui Wu* Coevolution is a short-distance force at the protein interaction level and correlates with the modular organization of protein networks. FEBS Letter 2010, 584:4237-4240

Education Background & Academic Experience
Dr. Jiarui Wu graduated in Dept.of Biology of Zhongshan University in Guangzhou in 1982, received a master degree from Institute of Genetics of Chinese Academy of Sciences in Beijing in 1985 and a doctor degree from Swiss Federal Institute of Technology in Zurich in 1994. He was a postdoctoral fellow in Dept. of Biochemistry and Molecular Biology, S.U.N.Y. Health Science Center in Syracuse, USA from 1994-1997. Since then, he become a professor in Shanghai Institute of Biochemistry in Chinese Academy of Sciences in Shanghai.


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