Home CAS Center for Excellence


Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
LI Zhenfei
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: zhenfei.li@sibcb.ac.cn

Research Areas
Androgen metabolism in castration resistant prostate cancer

Research Interests
Prostate cancer is the most common cancer in man and castration resistant prostate cancer (CRPC) is lethal. Hormone therapy by inhibiting androgen receptor signaling is one major treatment plan for CRPC patients. We focus on steroidogenesis and drug metabolism to unveil drug resistant mechanisms and discover novel targets for treatment or biomarkers for prognosis. Specifically, we are interested in these areas:
1. Drug metabolism and its application in clinic;
2. Drug resistant mechanisms and new target for therapy;
3. Crosstalk between AR signaling and other signalings in CRPC;
4. Hormone metabolism in other cancers.

Selected Publications

  1. Zhenfei Li, Mohammad Alyammani, Jianneng Li, Kevin Rogacki, Mohamed Abazeed, Sunil Upadhyay, Steven P. Balk, Mary-Ellen Taplin, Richard J. Auchus, Nima Sharifi. Redirecting abiraterone metabolism to biochemically fine tune prostate cancer therapy. Nature. 533, 547-551 (2016).
  2. Mohammad Alyamani, Zhenfei Li, Sunil K Upadhyay, David J Anderson, Richard J Auchus, Nima Sharifi. Development and validation of a novel LCCMS/MS method for simultaneous determination of abiraterone and its seven steroidal metabolites in human serum: Innovation in separation of diastereoisomers without use of a chiral column. J Steroid Biochem Mol Biol, doi: 10.1016. (2016).
  3. Zhenfei Li, Andrew Bishop, Mohammad Alyamani, Jorge A. Garcia, Robert Dreicer, Dustin Bunch, Jiayan Liu, Sunil K. Upadhyay, Richard J. Auchus, Nima Sharifi. Conversion of abiraterone to D4A drives antitumor activity in prostate cancer. Nature. 523, 347-351 (2015).
  4. Hamid Emamekhoo, Zhenfei Li and Nima Sharifi. Clinical significance of D4A in prostate cancer therapy with abiraterone. Cell cycle. 14, 3213-3214 (2015).
  5. Cong Fei, Zhenfei Li, Chen Li, Yuelei Chen, Zhangcheng Chen, Xiaoli He, Li Mao, XinWang, Rong Zeng and Lin Li. Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/beta-catenin signaling. Mol Cell Biol. 33, 4095-105 (2013).
  6. Zhenfei Li*, Fen Nie*, Sheng Wang, Lin Li. Histone 4 Lys-20 Mono-Methylation by SET8 Mediates Wnt Target Gene Activation. Proc Natl Acad Sci USA. 108, 3116-23 (2011). (*co-first author)
  7. Zhihui Xie*, Yongfeng Chen*, Zhenfei Li, Ge Bai, Yue Zhu, Ye-Guang Chen, Francois Guillemot, Lin Li, Naihe Jing. Smad6 Inhibits Wnt/β-catenin Pathway by Recruiting CtBP to Promote Neuronal Differentiation. Proc Natl Acad Sci USA. 108, 12119-24 (2011). (*co-first author)
  8. Meng Li, He Wang, Tao Huang, Jiyong Wang, Yu Ding, Zhenfei Li, Jinkuo Zhang and Lin Li. TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. J Biol Chem. 285, 13397-13404 (2010).

Education Background & Academic Experience
2016-present: Principle investigator, Center of Translational Medicine by Shanghai Institute of Biochemistry and Cell Biology, SIBS, CAS and Changhai Hospital, the Second Military Medical University
2013-2016: Postdoctoral researcher, Cleveland Clinic, US
2012-2013: Postdoctoral researcher, UT Southwestern Medical Center, US
2005-2011: Graduate student (PhD), Shanghai Institute of Biochemistry and Cell Biology, CAS
2001-2005: undergraduate student, Life Science department, Fudan University


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