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Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: bo.zhou@@sibcb.ac.cn

Research Areas
Hematopoietic stem cells and mesenchymal stem cells

Research Interests

Our laboratory studies the mechanisms that regulate stem cell self-renewal and the ways by which such mechanisms get hijacked by cancer. Our laboratory has two major research focuses:
1. The cellular identity of hematopoietic stem cell niche
Hematopoietic stem cells (HSCs) are self-renewable progenitor cells that give rise to all blood cell lineages during development and after injury. HSCs are the most clinically used adult stem cells nowadays. Every year there are thousands of patients whose lives are saved as a result of HSC transplant; however, there are thousands of more patients who could be treated more effectively if we could just get more HSCs. Despite decades of effort, we are still very limited in our ability to expand these blood-forming stem cells in culture. One possibility is that the microenvironment that supports HSC self-renewal in vivo, called stem cell niche, is also essential for their maintenance in vitro. Therefore, our research interest is to elucidate the exact cellular identity of HSC niche in vivo and to reconstruct it in vitro.
2. The physiological functions of mesenchymal stem cells
Mesenchymal stem cells (MSCs) are colony-forming unit-fibroblasts (CFU-Fs) in adult bone marrow whose primary physiological function is to generate bone, cartilage, marrow adipocytes and hematopoiesis-supportive niche. Following intravenous infusion, culture-expanded MSCs are able to home to injured tissue and facilitate tissue repair, likely through immunomodulation and/or cell replacement. Because of these properties, MSCs are the focus of hundreds of clinical trials, targeting not only skeletal diseases but also diseases beyond skeleton, such as diabetes, stroke and all types of fibrotic diseases. However, these putative therapeutic effects of MSCs have never been evidenced in vivo, which questions the scientific foundation for the current MSC-based therapies. Therefore, our research interest is to investigate to what extent endogenous MSCs contribute to tissue repair and regeneration in different organs.

Selected Publications

  1. Yi Jacky Peng, Hua Yu, Xiaoxin Hao, Wenjie Dong, Xiujuan Yin, Minghui Lin, Junke Zheng and Bo O. Zhou. 2018. Luteinizing hormone signaling restricts hematopoietic stem cell expansion during puberty. EMBO J  doi: 10.15252/embj.201898984
  2. Qi Jason Yao, Lina Sang, Minghui Lin, Xiujuan Yin, Wenjie Dong, Yuping Gong and Bo O. Zhou. 2018. Mettl3-Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells. Cell Res doi: 10.1038/s41422-018-0062-2
  3. Bo O. Zhou*, Hua Yu, Rui Yue, Jonathan J. Rios, Olaia Naveiras and Sean J. Morrison*. 2017. Bone marrow adipocytes promote the regeneration of stem cells and hematopoiesis after irradiation by secreting SCF. Nat Cell Biol 19, 851-903 (Cover story, *co-corresponding authors)
  4. Bo O. Zhou, Linheng Li, Meng Zhao. 2017. ¡°The evolvement of hematopoietic stem cell niches¡± in Advances in Stem Cells and Their Niches, volume 1. Elsevier, 2017 (Book chapter)
  5. Christopher N. Inra#, Bo O. Zhou#, Melih Acar, Malea M. Murphy, James Richardson, Zhiyu Zhao, Sean J. Morrison. 2015. A perisinusoidal niche for extramedullary haematopoiesis in the spleen. Nature (Article) 527:466-471. (#co-first authors)
  6. Bo O. Zhou#, Lei Ding#, Sean J. Morrison. 2015. Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1. eLife 4:e05521.£¨#co-first authors£©
  7. Bo O. Zhou, Rui Yue, Malea M. Murphy, James Peyer, Sean J. Morrison. 2014. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15:154-168.
  8. Bo O. Zhou, Jin-Qiu Zhou. 2011. Recent transcription-induced histone H3 lysine 4 (H3K4) methylation inhibits gene reactivation. J Biol Chem 286:34770-34776.
  9. Bo O. Zhou, Shan-Shan Wang, Yang Zhang, Xiao-Hong Fu, Wei Dang, Brian A. Lenzmeier, Jin-Qiu Zhou. 2011. Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae. PLoS Genet 7:e1001272.
  10. Bo O. Zhou, Shan-Shan Wang, Lu-Xia Xu, Fei-Long Meng, Yao-Ji Xuan, Yi-Min Duan, Jian-Yong Wang, Hao Hu, Xianchi Dong, Jianping Ding, Jin-Qiu Zhou. 2010. SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation. Mol Cell Biol 30:2391-2400.
  11. Shan-Shan Wang, Bo O. Zhou*, Jin-Qiu Zhou*. 2011. Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter. Mol Cell Biol 31:3171-3181.£¨*co-corresponding authors£©
  12. Deng-Hong Zhang#, Bo O. Zhou#, Yu Huang, Lu-Xia Xu, Jin-Qiu Zhou. 2006. The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. Nucleic Acids Res 34:1393-1404.£¨#co-first authors£©

Education Background & Academic Experience

Principle investigator, Shanghai Institute of Biochemistry and Cell Biology, CAS
Postdoctoral fellow, University of Texas Southwestern Medical Center (UTSW), USA
Research Associate, Shanghai Institute of Biochemistry and Cell Biology, CAS
Ph.D. student, Shanghai Institute of Biochemistry and Cell Biology, CAS
Undergraduate student, East China Normal University (ECNU)

Honors & Awards

Award for Excellence in Postdoctoral Research, UTSW, USA
Leukemia & Lymphoma Society Fellowship, USA
Pfizer Special Award for Outstanding Graduate Student, China
Australia-China Biomedical Research Conference, Travel award
"Yinglai Wang" Scholarship, China
Best Graduate Student Model award, Chinese Academy of Sciences, China
Municipal Outstanding Student award, Shanghai, China
First Prize Scholarship of ECNU, China
First Prize Scholarship of ECNU, China
First Prize Scholarship of ECNU, China

Research Team


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