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Faculty

Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
 
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
 
Principal Investigators
 
MENG Feilong
Ph.D.
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: Feilong.Meng@@sibcb.ac.cn

Research Interests
The Meng lab studies genome alterations in B-lymphocytes and cancer cells using emerging high throughput genomic technologies and mouse genetic models.
Upon pathogen stimulation, resting naïve B cells can undergo genome alterations including Immunoglobulin variable region exon somatic hypermutation (SHM) and Immunoglobulin Heavy chain (IgH) class switch recombination (CSR), to generate antibodies with higher affinity and proper effector functions. Activation induced cytidine deaminase (AID) initiates both SHM and CSR processes via cytidine deamination of single-strand (ss) DNA targets in a transcription-dependent manner. While largely specific for Ig genes, AID also acts on a limited set of off-targets, generating oncogenic translocations and mutations that contribute to B cell lymphoma. Our studies have revealed roles of RNA exosome and convergent transcription in AID-initiated programmed DNA lesions and genomic instability. In this context, convergently transcribed intragenic super-enhancers (SEs) are the major source of genome instability in B cell lymphomas. Similar mechanisms could contribute to AID-initiated antibody somatic hypermutations (SHM) and AID/Apobec initiated clustered mutations (kataegis) in various cancer genomes. We will use B cell immune system to further investigate the roles of AID/Apobec DNA mutator enzymes and non-coding RNA processing in genome instability. Current projects include 1). Regulatory RNA; 2). Germinal center B cells and Somatic Hypermutation; 3). AID/Apobec activity regulation in B cells and other tumor cells.

Selected Publications

  1. Meng FL*, Du Z*, Federation A*, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig M, Bradner JE#, Liu XS#, Alt FW# (2014) Convergent Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability. Cell. 159, 1538-1548. * Co-first author
  2. Alt FW, Zhang Y, Meng FL, Guo C, Schwer B (2013) Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell. 152(3):417-29
  3. Basu U*, Meng FL*, Keim C*, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. (2011) The RNA Exosome Targets Activation Induced Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates. Cell 144(3):353-63. * Co-first author
  4. Ba Z*, Meng FL*, Gostissa M*, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, and Alt FW. (2015) A Rapid Embryonic Stem CellCBased Mouse Model for B-cell Lymphomas Driven by EpsteinCBarr Virus Protein LMP1. Cancer Immunology Research doi: 10.1158/2326-6066.CIR-15-0058 In Press * Co-first author
  5. Meng FL, Chen XF, Hu Y, Tang HB, Dang W and Zhou JQ (2010) Sua5p is required for telomere recombination in Saccharomyces cerevisiae. Cell Research 20(4),495-8
  6. Meng FL, Hu Y, Shen N, Tong XJ, Wang J, Ding J and Zhou JQ (2009) Sua5p a Single-stranded Telomeric DNA Binding Protein Facilitates Telomere Replication. EMBO Journal 28, 1466-1478.
  7. Fu XH*, Meng FL*, Hu Y, Zhou JQ (2008) Candida albicans, a distinctive fungal model for cellular aging study. Aging Cell 7: 746-757 * Co-first author

Education Background & Academic Experience
2015-Present: Principal Investigator, Institute of Biochemistry and Cell Biology (IBCB), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS).
2009-2015: Postdoctoral Fellow, Howard Hughes Medical Institute; Program of Cellular & Molecular Medicine at Boston Children¨s Hospital; Harvard Medical School
2003-2009: Ph.D. in Biochemistry and Molecular Biology, Institute of Biochemistry and Cell Biology (IBCB), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS).
1999-2003: B.S. in Biology, College of Life Sciences, Nankai University.
AWARDS AND FELLOWSHIPS:
2014-15: Lymphoma Research Foundation Postdoctoral Fellowship
2011-13: Cancer Research Institute Research Fellowship
2009: The President Award of Chinese Academy of Sciences
2008: Travel Grant of International Union of Biochemistry and Molecular Biology (IUBMB) Fellowship
2002: Chinese Academy of Sciences Scholarship
2001: Diagnostic Products Corporation (DPC) Scholarship
2000-02: Scholarships for Academic Excellence, Nankai University

 

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