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Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
TONG Ming-Han
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: minghan@@sibcb.ac.cn

Research Interests
Male factor infertility occurs in about 10% of men. Normal fertility in the male depends on spermatogenesis for the constant production of sperm throughout the life of the male. Spermatogenesis is highly coordinated and very complex, involving three major biological fundamentals (1) mitosis: the self-renewal of spermatogonial stem cells (SSCs) and the expansion of their progenitor cells; (2) meiosis: the reduction of the chromosome numbers by one-half in parent cells; (3) spermiogenesis: the unique remodeling of round haploid cells into mobile cells with flagella.
Research in the Tong laboratory focuses on mammalian spermatogenesis. The primary goal of the Tong laboratory is the use of molecular and cellular techniques and in vivo animal model systems to uncover basic mechanisms responsible for the fate decision of SSCs and the initiation of meiosis, with the aim being to make the spermatid in the culture dish.

Selected Publications

  1. Yao Chen, Yuxuan Zheng, Yun Gao, Zhen Lin, Suming Yang, Tongtong Wang, Qiu Wang, Nannan Xie, Rong Hua,Mingxi Liu, Jiahao Sha, Michael D. Griswold, Jinsong Li*, Fuchou Tang* and Ming-Han Tong* 2018 Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis. Cell Research. [Epub ahead of print] (Cover paper) *Corresponding author. (Highlighted by NSR)
  2. Xiaoli Zuo, Bowen Rong, Li Li, Ruitu Lv, Fei Lan*, and Ming-Han Tong* 2018 The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. Journal of Biological Chemistry. 293(24) 9188-9197 PMID: 29716999 *Corresponding author
  3. Tongtong Wang, Qianqian Yin, Xuehao Ma, Ming-Han Tong*, Yuchuan Zhou* 2018 Ccdc87 is critical for sperm function and male fertility. Biol Reprod. [Epub ahead of print] PMID: 29733332 *Corresponding author
  4. Zhen Lin,Phillip J Hsu,Xudong Xing,Jianhuo Fang,Zhike Lu,Qin Zou,Ke-Jia Zhang,Xiao Zhang,Yuchuan Zhou,Teng Zhang,Youcheng Zhang,Wanlu Song,Guifang Jia, Xuerui Yang*,Chuan He*,Ming-Han Tong* 2017 Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis.Cell Research. 27(10): 1216-1230 PMID: 28914256 *Corresponding author. (Highlighted by NSR)
  5. Yao Chen,Li Ma,Cathryn Hogarth,Gang Wei,Michael D. Griswold*Ming-Han Tong* 2016 Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes. Development. 143(9): 1502-1511 PMID: 26965368 *Corresponding author. (Highlighted article)
  6. Tong, Ming-han* Li, Jinsong* 2015 Similarity of epigenetic reprogramming in primordial germ cells between human and mouse. National Science Review.12, 2(4): 384 *Corresponding author
  7. Ming-Han Tong*, Qi-En Yang, Jeffrey C. Davis, and Michael D. Griswold* 2013   Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males. ProcNatlAcadSci U S A. 110(2): 543-8 PMID: 23267101    * Corresponding author
  8. Ming-Han Tong*, Debra Mitchell, Samantha McGowan and Michael D.Griswold* 2012 Two miRNAs Clusters, Mir-17-92 and Mir-106b-25, Are Involved in the Regulation of Spermatogonial Differentiation. Biol Reprod. 86(3): 72 1-10 PMID: 22116806 * Corresponding author
  9. Ming-Han Tong, Debra Mitchell, Ryan Evanoff and Michael D.Griswold 2011 Expression of Mirlet7 Family MicroRNAs in Response to Retinoic Acid-Induced Spermatogonial Differentiation in Mice. Biol Reprod. 85 (1): 189-97 PMID: 21430230
  10. Tong MH, Jiang H, Liu P, Lawson JA, Brass LF, Song WC. 2005 Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Nat Med. 11(2): 153-9 PMID: 15685171

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