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Faculty

Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
 
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
 
Principal Investigators
 
ZOU Weiguo
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: zouwg94@@sibcb.ac.cn

Research Interests

This laboratory focuses on systemically discovering the molecular and genetic mechanisms that govern bone development and bone remodeling, with the ultimate goal of the design of better therapeutics to treat bone diseases, such as osteoporosis, craniofacial anomalies and osteoarthritis, etc. The approaches employed in the laboratory include in vitro biochemistry, molecular and cellular biology and in vivo animal study, centering on skeleton biology of genetically manipulated mice. The topics we are interested in include:
1.    Identifying novel regulators and pathways for osteoblast/osteoclast differentiation and function.
2.    Studying the mechanisms of the coupling between bone formation and bone resorption.
3.    Uncovering the pathological mechanisms of various skeletal disorders, such as osteoporosis, craniofacial anomalies and osteoarthritis, etc.

Selected Publications

1.Han Y, You X, Xing W, Zhang Z, Zou W*. (2018) Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Research. May 24; 6:16.
2.Sun J, Ermann J, Niu N, Yan G, Yang Y, Shi Y, Zou W*. (2018) Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Research. Apr 26; 6:14.
3.Dai Q, Xu Z, Ma X, Niu N, Zhou S, Xie F, Jiang L, Wang J*, Zou W*.(*corresponding author) (2017) mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression. Cell Death and Differentiation 24, 1886C1899.
4.Dai Q, Xie F, Han Y, Ma X, Zhou S, Jiang L*, Zou W.* Wang J*.(2017)Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice. The Journal of Biological Chemistry. VOL. 292, NO. 1, pp. 196C204.
5. Xu Z, Greenblatt MB, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher LH, Zou W*. (2017) SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nature Communications 8:14570.
6.Niu N, Xiang JF, Yang Q, Wang L, Wei Z, Chen LL, Yang L, Zou W*. (2017) RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression. Cell Discovery 3, 16050.
7.Niu N, Shao R, Yan G, Zou W*. (2016) Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth. The Journal of Biological Chemistry VOL. 291, NO. 52, pp. 26647C26657.
8.Liu J, Wan L, Liu J, Yuan Z, Zhang J, Guo J, Malumbres M, Liu J*, Zou W*, Wei W*.(2016)Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discovery, 2, 15044.
9.Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L*, Wei W*, Zou W*. (2016) Cdh1 regulates Craniofacial Development via APC-dependent Activation of Goosecoid. Cell Research, 26:699-712.
10.Liu Z, Yao X, Yan G, Xu Y, Yan J, Zou W*, Wang G*.(2016) Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nature Communications,7: 11149.
11.Zou, W*, Greenblatt, M.B., Brady, N., Lotinun, S., Zhai, B., de Rivera, H., Singh, A., Sun, J., Gygi, S.P., Baron, R., Glimcher, L.H., Jones, D.C.(2013) The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. J Exp Med. 210, 1793-806.
12.Zou, W., Chen, X., Shim, J.H., Huang, Z., Brady N., Hu, D.Z, Drapp, R., Sigrist, K., Glimcher, L.H. and Jones, D.C. (2011) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13, 59C65.
13.Zou, W.*, Greenblatt, M.B.* (*co-first author), Shim, J.H., Kant, S., Zhai, B., Brady, B., Hu, D.Z., Gygi, S.P., Davis, R., Jones, D.C. and Glimcher, L.H. (2011) MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1. J ClinInvest . 121, 4383-92.
14.Wan, L.*, Zou, W.* (*co-first author), Gao, D., Inuzuka, H., Drapp, R., Shaik, S., Eguren, M., Hu, D.Z., Malumbres, M., Glimcher L.H. and Wei W. (2011) Cdh1 Regulates Osteoblast functions through an APC/C-independent modulation of Smurf1. Molecular Cell. 44, 721-33.
15.Shim, J.H, Greenblatt, M.B., Zou, W., Huang, Z., Wein, M.N., Brady N., Hu, D., Charron, J., Brodkin, H.R., Petsko, G.A., Zaller, D., Zhai, B., Gygi, S., Glimcher, L.H., Jones, D.C. 2013 Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 123:4010-22.
16.Greenblatt, M.B., Shim, J.H., Zou, W., Sitara, D., Schweitzer, M., Hu, D., Lotinun, S., Sano, Y., Baron, R., Park, J.M., Arthur, S., Xie, M., Schneider, M.D., Zhai, B., Gygi, S., Davis, R., Glimcher, L.H. (2010) The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 120, 2457-73.
17.Shim J,H., Greenblatt, M.B., Xie, M., Schneider, M.D., Zou, W., Zhai, B., Gygi, S., Glimcher, L.H. (2009) TAK1 is an essential regulator of BMP ignaling in cartilage. EMBO J. 28, 2028-41.
18.Zou, W., Kim, J.H., Handidu, A., Li, X., Kim, K.I., Yan, M., Li, J., Zhang D.E. (2007). Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages. BiochemBiophys Res Commun. 356, 193-9.
19.Zou,W., Wang, J., and Zhang,D.E. (2007). Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. BiochemBiophys Res Commun., 354, 321-327.
20.Okumura, F., Zou, W., and Zhang, D.E. (2007).ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. Genes Dev., 21, 255 C 260.
21.Malakhova, O.A., Kim, K.I., Luo, J.K., Zou, W., Kumar, K.G., Fuchs, S.Y., Shuai, K., Zhang, D.E. (2006) UBP43 is a novel regulator of interferon signaling independent of its ISG15isopeptidase activity. EMBO J. 25, 2358-2367.
22.Zou,W. and Zhang,D.E. (2006). The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. J Biol. Chem. 281, 3989-3994.
23.Kim, K.I., Yan, M., Malakhova, O., Luo, J.K., Shen, M.F., Zou, W., de la Torre, J.C., Zhang, DE. (2006). Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol Cell Biol. 26, 472-479.
24.Zou,W., Papov,V., Malakhova,O., Kim,K.I., Dao,C., Li,J., and Zhang,D.E. (2005). ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin. Biochem. Biophys. Res. Commun. 336, 61-68.
25.Liu, X., Qiu, S., Zou, W., Pei, Z., Gu, J., Luo, C., Ruan, H., Chen, Y., Qi, Y., Qian, C.. (2005) Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5. MolTher. 11, 531-541.
26.Zhang, Z., Zou, W., Wang, J., Gu, J., Dang, Y., Li, B., Zhao, L., Qian, C., Qian, Q., Liu, X. (2005) Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, soluble Flt-1. MolTher. 11, 553-562.
27.Zou,W., Luo,C., Zhang,Z., Liu,J., Gu,J., Pei,Z., Qian,C., and Liu,X. (2004). A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent antitumoral efficiency. Oncogene 23, 457-464.
28.Xu, W., Yu, F., Yan, M., Lu, L., Zou, W., Sun, L., Zheng, Z., Liu, X. (2004). Geldanamycin, a heat shock protein 90-binding agent, disrupts Stat5 activation in IL-2-stimulated cells. J Cell Physiol. 198, 188-96.
29.Pei, Z., Chu, L., Zou, W., Zhang, Z., Qiu, S., Qi, R., Gu, J., Qian, C., Liu, X. (2004) An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice. Hepatology. 39, 1371-1381.
30.Zhang, Z*, Zou,W* (*co-first author), Luo,C., Li,B., Wang,J., Sun,L., Qian,Q., and Liu,X. (2003). An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy. Cell Res. 13, 481-489.
31.Zou,W*., Zeng,J.* (*co-first author), Zhuo,M., Xu,W., Sun,L., Wang,J., and Liu,X. (2002). Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells. J Neurosci. Res. 67, 837-843.
32.Zou,W., Wang,D., Lang,M., Jin,D., Xu,D., Zheng,Z., Wu,Z., and Liu,X. (2002). Human interleukin 10 gene therapy decreases the severity and mortality of lethal pancreatitis in rats. J Surg. Res. 103, 121-126.
33.Liu,J., Zou,W., Lang,M., Luo,J., Sun,L., Wang,X., Qian,Q., and Liu,X. (2002). Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. Int. J Oncol. 21, 661-666.
34.Zou,W., Yan,M., Xu,W., Huo,H., Sun,L., Zheng,Z., and Liu,X. (2001). Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. J Neurosci. Res. 64, 646-653.

Education Background & Academic Experience

2012.8-present   Principle investigator, Shanghai Institute of Biochemistry and Cell Biology, CAS
2007-2012         Research Fellow, Yerby Fellow, Harvard School of Public Health, Boston, MA
2003-2007         Research Associate, The Scripps Research Institute, La Jolla, CA
1998-2003         Ph.D., Shanghai Institute of Biochemistry and Cell Biology,  CAS,  China
1994-1998         B.A.,  Nankai University, Tianjin, China
 
Awards
2010     Yerby Fellow, Harvard School of Public Health
2007     Julia Rowe Award, Leukemia & Lymphoma Society
2005     Career Development Fellowship, Leukemia & Lymphoma Society
2002     Di¨ao Scholarship, Chinese Academy of Sciences
2001     Di¨ao Scholarship, Chinese Academy of Sciences

 

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