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Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
GAO Daming
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: dgao@@sibcb.ac.cn

Research Interests
One major feature of cancer cells is that they could divide unlimitedly. Many cellular alterations contribute to this phenotype, including signaling pathways involved in cell cycle progression, signaling transduction, and cell survival. My research interests mainly focus on defining the basic regulatory mechanisms, especially the key post-translational modifications of important signaling transducers, controlling cancer cell proliferation and metabolism, which may reveal novel cancer-specific signaling axis and lead to identification of new therapeutic targets for cancer treatment.

Selected Publications

  1. Inuzuka H*, Gao D*, Finley L, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, and Wei W. Acetylation-Dependent Regulation of Skp2 Function. Cell, 2012, 150: 179-93. * Co-first author
  2. Gao D*, Inuzuka I*, Tan M*, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW and Wei W. mTOR drives its own activation via SCFb-TRCP-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell, 2011, 44: 290-303 (* Co-first author)
  3. Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennet E, Tron AE, Gasser JA, Lau A, Gygi S, Harper JW, DeCaprio JA, Toker A and Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell, 2010, 39: 797-808
  4. Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N and Wei W. Cdh1 regulates cell cycle through modulating the Claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell, 2009, 20: 3305-3316
  5. Gao D, Inuzuka H, Tseng A, Chin R, Toker A and Wei W. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APC/Cdh1-medaited Skp2 destruction. Nat Cell Biol, 2009, 11: 397-408

Education Background & Academic Experience
2001 June, B.Sc., Shandong University, China
2006 July, Ph.D., Shanghai Institute of Biochemistry and Cell Biology, CAS, China
2006 December-2010 July, Postdoctoral Research Fellow, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
2010 August-2012 July, Instructor, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
2012 July-present, Principal Investigator, Institute of Biochemistry and Cell Biology, SIBS, CAS


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