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Faculty

Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
 
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
 
Principal Investigators
 
HOU Fajian
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: fhou@@sibcb.ac.cn

Research Interests
Our immune system includes innate immunity and adaptive immunity, which fight against infectious diseases. While adaptive immunity is antigen specific and takes longer time to be effective, innate immunity has no antigenic specificity but acts more swiftly. Innate immunity not only provides immediate defense for the host but also is important for developing a more specific and potent adaptive immune response. Distinct innate immune response is triggered by the detection of various invading pathogens. Pathogens are detected due to the so-called pathogen associated molecular patterns (PAMPs), include lipopolysaccharides, flagellin, and nucleic acids from bacteria, fungi, and viruses respectively. PAMPs are recognized by a group of evolutionarily conserved and germline-encoded receptors in host cells, which are called pattern recognition receptors (PRRs). The interaction between PAMPs and PRRs initiates a signaling cascade, leading to the production of proinflammatory cytokines and chemokines and eventually preventing the proliferation of pathogens. We are interested in dissecting distinct signal transduction pathways biochemically in innate immune response.

Selected Publications

  1. Shi Y#, Yuan B#, Qi N#, Zhu W, Su J, Li X, Qi P, Zhang D, Hou F*. An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response. Nat Commun. (2015) |6:78111|DOI: 10.1038/ncomms8811.
  2. Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ*. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell. (2011) 146(3), 448-61. (cover story)
  3. Chu CW, Hou F, Zhang J, Phu L, Loktev AV, Kirkpatrick DS, Jackson PK, Zhao Y, Zou H*. A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation. Mol Biol Cell. (2011) 22(4), 448-56.
  4. Zeng W, Sun L, Jiang X, Chen X, Hou F, Adhikari A, Xu M, Chen ZJ*. Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell. (2010) 141(2), 315-30.
  5. Hou F, Chu CW, Kong X, Yokomori K, Zou H*. The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner. J Cell Biol. (2007) 177(4), 587-97.
  6. Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, Amanai K, Jiang J*. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell. (2005) 9(6), 819-30.
  7. Hou F, Zou H*. Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion. Mol Biol Cell. (2005) 16(8), 3908-18.

Education Background & Academic Experience
1995 B.Sc., Wuhan University, China
2001 Ph.D., Shanghai Institute of Biochemistry, CAS, China
2001-2012 Postdoctoral Researcher, Department of Molecular Biology, University of Texas Southwestern Medical Center, USA
2012-present Principal Investigator, Institute of Biochemistry and Cell Biology, SIBS, CAS

 

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