Home CAS Center for Excellence


Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
HE Yongning
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: he@@sibcb.ac.cn

Research Interests
Our laboratory is interested in the structures of cell surface receptors and receptor-ligand interactions. We are combining various molecular and structural techniques, including three-dimensional (3D) reconstruction by electron microscopy (single particle reconstruction, tomography, etc.), X-ray crystallography and small angle X-ray scattering, to determine 3D structures of cell surface molecules and the corresponding complexes involved in immunological recognition, antibody transport, cell adhesion and viral cell entry.

Selected Publications

  1. Yu B, Hu Z, Kong D, Cheng C, He Y* (2019). Crystal structure of the CTLD7 domain of human M-type phospholipase A2 receptor. J Struct Biol. pii: S1047-8477(19)30136-4.
  2. Cao L, Yu B, Kong D, Cong Q, Yu T, Chen Z, Hu Z, Chang H, Zhong J, Baker D, He Y* (2019). Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus. PLoS Pathog. 15(5):e1007759. doi: 10.1371/journal.ppat.1007759.
  3. Tang H, Chang H, Dong Y, Guo L, Shi X, Wu Y, Huang Y, He Y* (2018). Architecture of cell-cell adhesion mediated by sidekicks. Proc Natl Acad Sci U S A. 115, 9246-9251.
  4. Hu Z, Shi X, Yu B, Li N, Huang Y, He Y* (2018). Structural insights into the pH-dependent conformational change and collagen recognition of the human mannose receptor. Structure 26, 60-71.e3.
  5. Dong Y, Cao L, Tang H, Shi X, He Y* (2017). Structure of human M-type phospholipase A2 receptor revealed by cryo-electron microscopy. J Mol Biol. 429, 3825-3835.
  6. Cao L, Chang H, Shi X, Peng C, He Y* (2016). Keratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205. Proc Natl Acad Sci U S A. 113, 13438-13443.
  7. Cao L, Shi X, Chang H, Zhang Q, He Y* (2015). pH-Dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205. Proc Natl Acad Sci USA. 112, 7237-42.
  8. He W, He Y (2014). Electron tomography for organelles, cells, and tissues. Methods Mol. Biol. 1117, 445-83.

Education Background & Academic Experience
1991, B.S. Fudan University, Shanghai, China
1994, M.S. Fudan University, Shanghai, China
2002, Ph.D Purdue University, West Lafayette, IN USA
2003-2011, Postdoc, Staff Scientist, California Institute of Technology, Pasadena, CA USA
2011-, Professor, Shanghai Institute of Biochemistry and Cell Biology, Shanghai, China

Research Team


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