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Research Areas

State Key Laboratory of Molecular Biology

State Key Laboratory of Cell Biology

Principal Investigators

Center for Cell Signaling

National Center for Protein Science Shanghai

Members of CAS, CAE

National Outstanding Young Scientists Award

100 Talents Program of the CAS

Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
CHEN Lingling
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: linglingchen@sibcb.ac.cn

Research Interests
The complete sequence of the human genome provided quite a surprise to many by revealing that more than 98% of the transcriptional output represents non-protein coding RNAs (ncRNAs). In addition to housekeeping ncRNAs (rRNAs, tRNAs, etc.) and small RNAs (microRNAs, piRNAs, etc.), long noncoding RNAs (lncRNAs, >200nt) are emerging as a major class of eukaryotic transcripts with both reported and yet undiscovered roles in gene regulation.
Our long-term goal is to discovery new long noncoding RNA species and to study the mechanism of action of these RNAs regulation in mammalian cells. In the next five years, we are particularly interested in the following areas.
1) Identify new lncRNA species in human genomes by taking advantage of genome-wide approaches and computational analyses.
2) Explore new modes of gene expression regulation by these RNA transcripts with molecular/cell biological and biochemical approaches.
3) Understand the regulatory roles of particular lncRNAs in nuclear architecture and chromatin dynamics by genome editing technologies and living cell image systems.
4) Investigate lncRNAs involved in the renewal of human embryonic stem cells and gain insights into their regulatory roles in early development in primates.
Together, these studies have the potential to advance our understanding of the mechanisms and functional roles of lncRNA regulation in human genome.

Selected Publications

  1. Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L and Chen LL. (2013) Circular intronic long noncoding RNAs. Mol Cell, 51: 792-806.
    • Featured in Issue Highlight with a Preview Article in the same issue
    • Highlighted by Nature
  2. Zhang Y, Yang L, and Chen LL. (2013) Life without A tail: new formats of long noncoding RNAs. Int J Biochem and Cell Biol, in press.
  3. Zhu S, Xiang JF, Chen T, Chen LL, and Yang L. (2013) Prediction of constitutive A-to-I editing sites from human transcriptomes in the absence of genomic sequences. BMC Genomics, 14:206.
  4. Xiang JF, Yin QF, and Chen LL. (2013) Long noncoding RNAs: regulatory molecules in mammalian cells. Chin J Cell Biol, 35:262-272.
  5. Yin QF, Yang L, Zhang Y, Xiang JF, Wu YW, Carmichael GG and Chen LL. (2012) Long noncoding RNAs with snoRNA ends. Mol Cell, 48: 219-230.
    • Cover story
    • Featured in Issue Highlight with a Preview Article in the same issue
    • Highlighted by Nature Reviews Molecular Cell Biology
    • Recommended by F1000 Prime
    • Best of Molecular Cell 2012
  6. Chen LL and Carmichael GG. Nuclear editing of mRNA 3-UTRs. (2012) Curr Top Microbiol Immunol, 353:111-121.
  7. Yang L, Duff MO, Graveley BR, Carmichael GG and Chen LL. (2011) Genomewide characterization of non-polyadenylated RNAs. Genome Biol, 12: R16.
  8. Chen LL and Carmichael GG. (2010) Long non-coding RNAs in mammalian cells: What, Where and Why? WIREs RNA, 1: 2-21.
  9. Chen LL, Yang L and Carmichael GG. (2010) Molecular basis for an attenuated cytoplasmic dsRNA response in human embryonic stem cells. Cell Cycle, 9:3552-3564.
    • Featured in News & Views in the same issue
  10. Chen LL and Carmichael GG. (2010) Decoding the function of nuclear long non-coding RNAs. Curr Opin Cell Biol, 22: 357-364.
  11. Chen LL and Carmichael GG. (2009) Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA. Mol Cell, 35: 467-478.
    • Featured in Preview Article in the same issue
    • Recommended by F1000 Prime
  12. Chen LL and Carmichael GG. (2008) Gene regulation by SINES and inosines: biological consequences of A-to-I editing of Alu element inverted repeats. Cell Cycle, 7: 3297-3301.
  13. Chen LL, Decerbo JN and Carmichael GG. (2008) Alu element-mediated gene silencing. EMBO J, 27: 1694-1705.

Education Background & Academic Experience
2011-present: Principal Investigator, Institute of Biochemistry and Cell Biology, SIBS, CAS
2010-2011: Assistant Professor in residence, University of Connecticut Health Center, USA
2009-2010: Post-Doc fellow, University of Connecticut Stem Cell Institute, USA (Supported by Connecticut Stem Cell Seed Award, PI/Ling-Ling Chen)
2007-2009: M.B.A., University of Connecticut, USA
2004-2009: Ph.D., University of Connecticut, USA
2000-2003: M.S., Shanghai Institute of Materia Medica, CAS
1996-2000: B.S., Lanzhou University

Research Team

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