Home CAS Center for Excellence


Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
LI Dangsheng
Ph.D., Guest Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: dsli@@sibs.ac.cn

Selected Publications

  1. Zeng A., Y.Q. Li, C. Wang, X.S. Han, G. Li, J.Y. Wang, D. Li, Y.W. Qin, Y. Shi, G. Brewer, and Q. Jing. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. J Cell Biol. 201: 409-425 (2013).
  2. Cui L., Y. Guan, Z. Qu, J. Zhang, B. Liao, B. Ma, J. Qian, D. Li, W. Li, G.T. Xu, and Y. Jin. WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors. J Clin Invest. 123: 1647-1661 (2013).
  3. Zhao S., L.T. Gou, M. Zhang, L.D. Zu, M.M. Hua, Y. Hua, H.J. Shi, Y. Li, J. Li, D. Li, E.D. Wang, and M.F. Liu. piRNA-Triggered MIWI Ubiquitination and Removal by APC/C in Late Spermatogenesis. Dev Cell 24: 13-25 (2013)
  4. Li D. The 2013 special issue on stem cell biology. Cell Res. 23: 1-2 (2013)
  5. Li D. Sanofi-cell research outstanding paper award of 2011. Cell Res. 22: 1511 (2012)
  6. Yin J.W., Y. Liang, J.Y. Park, D. Chen, X. Yao, Q. Xiao, Z. Liu, B. Jiang, Y. Fu, M. Bao, Y. Huang, Y. Liu, J. Yan, M.S. Zhu, Z. Yang, P. Gao, B. Tian, D. Li, and G. Wang. Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev. 26: 2192-2205 (2012)
  7. Lin J., Z. Zhou, R. Huo, L. Xiao, G. Ouyang, L. Wang, Y. Sun, B. Shen, D. Li, and N. Li. Cyr61 Induces IL-6 Production by Fibroblast-like Synoviocytes Promoting Th17 Differentiation in Rheumatoid Arthritis. J Immunol. 188: 5776-5784 (2012)
  8. Yang H., L. Shi, B.A. Wang, D. Liang, C. Zhong, W. Liu, Y. Nie, J. Liu, J. Zhao, X. Gao, D. Li, G.L. Xu, and J. Li. Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. Cell 149: 605-617 (2012)
  9. Sun Y., C. Li, Y. Shu, X. Ju, Z. Zou, H. Wang, S. Rao, F. Guo, H. Liu, W. Nan, Y. Zhao, Y. Yan, J. Tang, C. Zhao, P. Yang, K. Liu, S. Wang, H. Lu, X. Li, L. Tan, R. Gao, J. Song J, X. Gao, X. Tian, Y. Qin, K.F. Xu, D. Li, N. Jin, and C. Jiang. Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection. Sci Signal. 21: 5(212):ra16 (2012)
  10. Jiang S., L.F. Zhang, H.W. Zhang, S. Hu, M.H. Lu, S. Liang, B. Li, Y. Li, D. Li, E.D. Wang, and M.F. Liu. A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. EMBO J. 31: 1985-1998 (2012)
  11. *Li D. A special issue on cell signaling, disease, and stem cells. Cell Res. 22: 1-2 (2012)
  12. Deng Y.Z., D. Yao, J.J. Li, Z.F. Mao, P.T. Hu, L.Y. Long, G. Li, X.D. Ji, S. Shi, D.X. Guan, Y.Y. Feng, L. Cui, D. Li, Y. Liu, X. Du, M.Z. Guo, L.Y. Xu, E.M. Li, H.Y. Wang, and D. Xie. RACK1 Suppresses Gastric Tumorigenesis by Stabilizing the β-Catenin Destruction Complex. Gastroenterology 142: 812-823 (2012)
  13. *Li D. Sanofi-Cell Research Outstanding Paper Award of 2010. Cell Res. 21: 1521-1522 (2011)
  14. Yang N., X. Hong, P. Yang, X. Ju, Y. Wang, J. Tang, C. Li, Q. Fan, F. Zhang, Z. Chen, L. Xing, Z. Zhao, X. Gao, G. Liao, Q. Li, X. Wang, D. Li, and C. Jiang. The 2009 pandemic A/Wenshan/01/2009 H1N1 induces apoptotic cell death in human airway epithelial cells. J. Mol. Cell Biol. 3: 221-229 (2011).
  15. Lin J., L. Shi, M. Zhang, H. Yang, Y. Qin, J. Zhang, D. Gong, X. Zhang, D. Li, and J. Li. Defects in trophoblast cell lineage account for the impaired in vivo development of cloned embryos generated by somatic nuclear transfer. Cell Stem Cell 8: 371-375 (2011).
  16. Zhang Q., J. Wu, Q. Cao, L. Xiao, L. Wang, D. He, G. Ouyang, J. Lin, B. Shen, Y. Shi, Y. Zhang, D. Li, and N. Li. A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum. 60: 3602-3612 (2009).
  17. Huang J., T. Chen, X. Liu, J. Jiang, J. Li, D. Li, X.S. Liu, W. Li, J. Kang, and G. Pei. More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells. Cell Res. 19: 1127-1138 (2009).
  18. *Li, D. JMCB: From China, for the world. J. Mol. Cell Biol. 1: 1-2 (2009)
  19. Kong, L., L. Sun, H. Zhang, Q. Liu, Y. Liu, L. Qin, G. Shi, J.H. Hu, A. Xu, Y.P. Sun, D. Li, Y.F. Shi, J.W. Zang, J. Zhu, Z. Chen, Z.G. Wang, and B.X. Ge. An essential role for RIG-I in toll-like receptor-stimulated phagocytosis. Cell Host Microbe. 6: 150-161 (2009)
  20. Zhang, Y., L. Wang, D. Li, and N. Li. Taming regulatory T cells by autologous T cell immunization: a potential new strategy for cancer immune therapy. Int. Immunopharmacol. 9: 593-595 (2009)
  21. Li, C., H. Liu , Y. Sun, H. Wang, F. Guo, S. Rao, J. Deng, Y. Zhang , Y. Miao, C. Guo, J. Meng, X. Chen, L. Li, D. Li, H. Xu, H. Wang, B. Li, and C. Jiang. PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway. J. Mol. Cell Biol. 1: 37-45 (2009)
  22. Luan, B., J. Zhao, H. Wu, B. Duan, G. Shu, X. Wang, D. Li, W. Jia, J. Kang, and G. Pei. Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature 457: 1146-1149 (2009)
  23. Yu, M.C., L.L. Su, L. Zou, Y. Liu, N. Wu, L. Kong, Z.H. Zhuang, L. Sun, H.P. Liu, J.H. Hu, D. Li, J.L. Strominger, J.W. Zang, G. Pei, and B.X. Ge. An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat Immunol. 9: 898-907 (2008)
  24. Du, F., L. Wang, Y. Zhang, W. Jiang, H. Sheng, Q. Cao, J. Wu, B. Shen, T. Shen, J.Z. Zhang, C. Bao, D. Li, and N. Li. Role of GADD45 beta in the regulation of synovial fluid T cell apoptosis in rheumatoid arthritis. Clin Immunol. 128: 238-247 (2008)
  25. Cao, Q., L. Wang, F. Du, H. Sheng, Y. Zhang, J. Wu, B. Shen, T. Shen, J. Zhang, D. Li, and N. Li. Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells. Cell Res. 17: 627-637 (2007)
  26. Shi, Y., Y. Feng, J. Kang, C. Liu, Z. Li, D. Li, W. Cao, J. Qiu, Z. Guo, E. Bi, L. Zang, C. Lu, J.Z. Zhang, and G. Pei. Critical regulation of CD4(+) T cell survival and autoimmunity by beta-arrestin 1. Nat Immunol. 8: 817-824 (2007)
  27. *Li, D. Cancer research in China: a special focus by Cell Research. Cell Res. 17: 273 (2007)
  28. Das, S., J.C. Nwachukwu, D. Li, A.I. Vulin, S. Martinez-Caballero, K.W. Kinnally, and H.H. Samuels. The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events. Cancer Res. 15: 1775-1782 (2007)
  29. *Li, D. and G. Pei. A special issue on stem cell research. Cell Res. 17: 1-2 (2007)
  30. *Li, D. Selective degradation of the IkappaB kinase (IKK) by autophagy. Cell Res. 16: 855-856 (2006)
  31. *Li, D. Peaking of MMP-26 and TIMP-4 marks invasive transition in prostate cancer. Cell Res. 16: 741 (2006)
  32. *Li, D. GSK-3beta as a driving force in ovarian cancer. Cell Res. 16: 609 (2006)
  33. *Li, D. Endothelial progenitor cells in debate. Cell Res. 16: 529 (2006)
  34. *Li, D. PGC-1α: looking behind the sweet treat for porphyria. Cell 122: 487-489 (2005)
  35. Li, D., M.A. Mahajan, and H.H. Samuels. Functional consequences of interactions between thyroid hormone receptors and retinoid X receptor. Current Opinion in Endocrinology & Diabetes. 12: 356-362 (2005)
  36. *Li, D., S. Das, T. Yamada, and H.H. Samuels. The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells. Mol. Cell. Biol. 24: 3838-3848 (2004)
  37. *Li, D., T. Yamada, F. Wang, A.I. Vulin, and H.H. Samuels. Novel roles of retinoid X receptor (RXR) and RXR ligand in dynamically modulating the activity of the thyroid hormone receptor/RXR heterodimer. J. Biol. Chem. 279: 7427-7437 (2004)
  38. Li, D., T. Li, F. Wang, H. Tian, and H.H. Samuels. Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer. Mol. Cell. Biol. 22: 5782-5792 (2002)
  39. Li, D., F. Wang, and H.H. Samuels. Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation. Mol. Cell. Biol. 21: 8371-8384 (2001)
  40. Li, D., V. Desai-Yajnik, E. Lo, M. Schapira, R. Abagyan, and H.H. Samuels. NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors. Mol. Cell. Biol. 19: 7191-7202 (1999)
  41. Rubin, B.P., D. Li, and W.K. Holloman. The Leu1 gene of Ustilago maydis. Gene 140: 131-135 (1994). 
    (* Corresponding author)

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