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Faculty

Members of CAS, CAE
Ten Thousand Talent Program Recipients
Thousand Talents Program Recipients
Innovative Group
National Outstanding Young Scientists Award
Thousand Talents Program Recipients by Shanghai Municipal Government
100 Talents Program of CAS
Youth Innovation Promotion Association CAS
Howard Hughes Medical Institute (HHMI) International Research Scholar
Max Planck Institute (MPI) Young Scientist
Newton Advanced Fellowship by the Royal Society
State Key Laboratory of Molecular Biology
State Key Laboratory of Cell Biology
Center for Cell Signaling
National Center for Protein Science Shanghai
Principal Investigators
 
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
 
Principal Investigators
 
HU Ping
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: hup@@sibcb.ac.cn

Research Interests
Adult stem cells need to integrate all the environment cues to determine whether to stay in quiescent stage or proliferate or differentiate.  The signaling pathways must communicate well with the transcription machinery to help cell make the right decision at the right time.  The molecular mechanism behind this communication between signaling pathways and transcription machinery is the focus of many studies.  Muscle stem cell represents a good model system to explore this mechanism.  Muscle stem cells have to communicate to the environment frequently to regenerate muscles upon stimuli such as exercise, muscle injury etc. This frequent convert between quiescence, proliferation, and differentiation in muscle stem cells give us a good opportunity to study the potential mechanism behind it.  Forkhead transcription factor family plays an important role during this process.  We will study the signaling pathways in muscle stem cells and roles of Forkhead family members in these cells using molecular biology, cell biology, mouse genentics, and super-resolution imaging techniques.
The major research interests in my lab are:
1. The functions of PI3K, MAPK, and shh signaling in the maintenance and differentiation of muscle stem cells.
2. The relationship between stem cell metabolism and their maintenance and differentiation.
3. The effects of adipocytes on metabolism and differentiation potential of muscle progenitor cells, and the transdifferentiation between muscle progenitor cells and other cell types.
4. Look for the progenitor of muscle stem cells, and compare the mechanisms governing embryonic muscle generation and adult muscle regeneration.

Selected Publications

  1. Skeletal muscle regeneration is modulated by inflammation. Wenjun Yang & Ping Hu*. Journal of Orthopaedic Translation. Accepted on Jan. 6, 2018.
  2. Dkk3 dependent transcriptional regulation controls ageing induced skeletal muscle atrophy. Jie Yin, Lele Yang, Yangli Xie, Yan Liu, Sheng Li, Wenjun Yang, Bo Xu, Hongbin Ji, Kun Wang, Gang Li, Lin Chen & Ping Hu*. Nature Communications. Accepted on Dec. 16, 2017.
  3. Hierarchical signaling transduction of the immune and muscle cell crosstalk in muscle regeneration. Wenjun Yang and Ping Hu*. Cell Immunol. 2017 Aug 24.
  4. MyoD and FoxO3 mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Yu Zhao, Bo Xu, Hao Sun, Ping Hu, Huangting Wang. Nucleic Acid Research, 45 (15): 8785C8805, 2017..
  5. Characterization and isolation of highly purified porcine satellite cells. Shijie Ding, Fei Wang, Yan Liu, Sheng Li, Guanghong Zhou,* and Ping Hu*. Cell Death Dis. 10(3):17003-17009, 2017.
  6. Characterization of mesoderm lineage. Wenjun Yang and Ping Hu*. Science in China (Series C:Life Sciences) , 08, pp 849-855, 2016.
  7. Hierarchical signaling transduction of the immune and muscle cell crosstalk in muscle regeneration. Wenjun Yang and Ping Hu*. Cell Immunol. 2017 Aug 24.
  8. MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Xianlu Peng, Karl K So, Liangqiang He, Yu Zhao, Jiajian Zhou, Yuying Li, Mingze Yao, Bo Xu, Suyang Zhang, Hongjie Yao, Ping Hu, Hao Sun and Huating Wang Nucleic Acids Res. 2017 Jun 1.
  9. Characterization and isolation of highly purified porcine satellite cells.Shijie Ding, Fei Wang, Yan Liu, Sheng Li, Guanghong Zhou,* and Ping Hu*. Cell Death Dis. 2017 Apr 10;3:17003.
  10. Characterization of mesoderm lineage. Wenjun Yang and Ping Hu*. Science in China(Series C:Life Sciences) , 08, pp 849-855, 2016.
  11. In vitro Differentiation of ESCs/iPSCs to Myogenic Lineage: Moving towards Cell Therapy.
    Julieta Gasparri and Ping Hu*. Experimental and Molecular Medicine 2016,1(1):9-12.
  12. A muscle secretive protein Msp marks ageing related muscular dystrophy. Jie Yin, Yan Liu, Wenjun Yang and Ping Hu*. Journal of Cachexia Sarcopenia and Muscle. 2015, 6: 409-413.
  13. Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion. Xin Fu, Jun Xiao, Yuning Wei, Sheng Li, Yan Liu, Kun Sun, Hao Sun, Huating Wang, Zongkang Max Zhang, Baoting Zhang, Chun Sheng, Hongyan Wang*, and Ping Hu*. Cell Research. 2015 Jun;25(6):655-73.( cover story with preview
  14. Stem cell activation in skeletal muscle regeneration. Xin Fu, Huating Wang, and Ping Hu*. Cellular and Molecular Life Sciences. 2015 May;72(9):1663-77. 
  15. Stem Cell and Regenerative Medicine, Chapter 10. Ping Hu. People¨s Health Publishing House. 2014. ISBN978!7-117-19242-2/R-19243.
  16. Mll2 controls cardiac lineage differentiation of mouse embryonic stem cells by promoting H3K4me3 deposition at cardiac-specific genes. Xiaoling Wan, Lulu Liu, Peipei Zhou, Zhouzhong Wen, Ping Hu, Bing Zhou and Yan Zhang. Stem Cell Reviews and Reports. 2014 Oct;10(5):643-52.
  17. Stimulation of Somatic Cell Reprogramming by ERas-Akt-FoxO1 Signaling Axis.Yong Yu, Dan liang, Qing Tian, Xiaona Chen, Bo jiang, Bin-kuan Chou, Ping Hu, Linzhao Cheng, Ping Gao, Jinsong Li and Gang Wang. Stem Cells. 2014 Feb;32(2):349-63.
  18. Forkhead transcription factors control stem cell fate determination. Jie Yin, Yuyin Yi, Xin Fu, and Ping Hu*. Chinese Journal of Cell Biology. 2012, 34(12): 1197-1206.
  19. Genome-wide roles of Foxa2 in directing liver specification. Chenhuan Xu, Xiaowen Lv, Zhang Chen, Zhiying He, Guangpeng Li, Yue Ma, Lijian Hui, Bin Xie, Yuan Gao, Xiaoyan Ding, Yiping Hu, Ping Hu *, Jing-Dong J. Han*, and Xin Wang. J Mol Cell Biol. 2012, 4(6), 420-422.
  20. Sub-Nuclear Spatial Segregation of Genes and Core Promoter Selectivity Factors. Jie Yao, Richard D. Fetter, Ping Hu, Eric Betzig and Robert Tjian. Genes and Development. 2011, 25(6):569-80..
  21. Co-dependent Activators Direct Myoblast Specific MyoD Transcription. Ping Hu, Kenneth G. Geles, Ji-Hye Paik, Ronald A. DePinho, and Robert Tjian. Developmental Cell. 2008, Oct; 15(4): 534-546.
  22. MyoD targets TAF3/TRF3 to activate myogenin transcription. Maria DE. Deato, Michael T. Marr, Theo Sottero, Carla Inouye, Ping Hu and Robert Tjian. Molecular cell. 2008, Oct 10; 32(1):96-105.
 

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