Home CAS Center for Excellence


Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
LIU Mofang
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: mfliu@@sibcb.ac.cn

Research Interests

The major research interests in Lius group are the roles and mechanisms of noncoding RNAs. The group is focusing on the studies of two important types of small noncoding RNAs, PIWI-interacting RNAs (piRNAs) and microRNAs (miRNAs). The goal of ongoing projects in the laboratory is to gain new insights into the function and mechanism of PIWI/piRNAs in mammal spermatogenesis and human male infertility as well as the function and mechanism of miRNAs in human cancers, especially in inflammation-associated tumorigenesis and cancer cell metabolism.

Selected Publications

  1. Gou LT, Kang JY, Dai P, Wang X, Li F, Zhao S, Zhang M, Hua MM, Lu Y, Zhu Y, Li Z, Chen H, Wu LG, Li D, Fu XD, Li J, Shi HJ*, Liu MF*. Ubiquitination-deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell, 2017:169:1090-1104.
  2. Zhang LF, Jiang S*, Liu MF*. MicroRNA regulation and analytical methods in cancer cell metabolism. Cell Mol Life Sci, 2017 Mar 20. doi: 10.1007/s00018-017-2508-y. [Epub ahead of print] 
  3. Yuan P, He XH, Rong YF, Cao J, Li Y, Hu Y, Liu Y, Li D, Lou W*, Liu MF*. KRAS-NFB-YY1-miR-489 signaling axis controls pancreatic cancer metastasis. Cancer Res, 2017, 77:100-111.
  4. He XH, Zhu W, Yuan P, Jiang S, Li D, Zhang HW, MF Liu*. miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells. Oncogene, 2016, 35:6015-6025.
  5. Zhang LF, Lou JT, Lu MH, Gao C, Zhao S, Li B, Liang S, Li Y, Li D, Liu MF*.  Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma. EMBO J, 2015, 34:2671-2685.
  6. Zhang P, Kang JY, Gou LT, Wang J, Xue Y, Skogerboe G, Dai P, Huang DW, Chen R, Fu XD*, Liu MF*, He S*. MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes. Cell Res, 2015, 25:193-207.
  7. Wang L, Zhang LF, Wu J, Xu SJ, Xu YY, Li D, Lou JT*, Liu MF*. IL-1-mediated repression of microRNA-101 is crucial for inflammation-promoted lung tumorigenesis. Cancer Res, 2014, 74:4720-4730.
  8. Gou LT, Dai P, Liu MF*. Small non-coding RNAs and male Infertility. WIREs RNA, 2014, 5:733-745.
  9. Gou LT, Dai P, Yang JH, Xue Y, Hu YP, Zhou Y, Kang JY, Wang X, Li H, Hua MM, Zhao S, Hu SD, Wu LG, Shi HJ, Li Y, Fu XD, Qu LH, Wang ED, Liu MF*.  Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis. Cell Res, 2014, 24:680-700.
  10. Hu S, Zhu W, Zhang LF, Pei M, Liu MF*.  MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer. Cell Res, 2014, 24:254-257.
  11. Zhao S, Gou LT, Zhang M, Zu LD, Hua MM, Hua Y, Shi HJ, Li Y, Li JS, Li DS, Wang ED*, Liu MF*.  piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Dev Cell, 2013, 24:13-25.
  12. Qiao M, Zu LD, He XH, Shen RL, Wang QC, Liu MF*.  Onconase down-regulates microRNA expression through targeting microRNA precursors. Cell Res, 2012, 22:1199-202.
  13. Jiang S, Zhang LF, Zhang HW, Hu S, Lu MH, Liang S, Li B, Li Y, Li D, Wang ED, Liu MF*. A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase2 in breast cancer cells. EMBO J, 2012, 31:1985-1998.
  14. Jiang S, Zhang HW, Lu MH, He XH, Li Y, Gu H, Liu MF*, Wang ED. MicroRNA-155 functions as an oncomiR in breast cancer by targeting the suppressor of cytokine signaling-1 gene. Cancer Res, 2010, 70: 3119-3127.
  15. Zhao S, Liu MF*. Mechanisms of miRNA-mediated gene regulation. Sci China C Life Sci, 2009, 52:1111-1116.

Education Background & Academic Experience

Dr. Mo-Fang Liu received her Bachelor and Masters degree in Biochemistry from East China University of Sciences and Technologies in 1991 and 1994, respectively. She obtained her Ph.D degree from Shanghai Institute of Biochemistry, Chinese Academy of Sciences in 2000. From 2000 to 2006, she was a postdoctoral fellow in National Cancer Institute, NIH, and then as a research assistant in Howard Hughes Medical Institute, Johns Hopkins University School of Medicine. She joined in Shanghai Institute of Biochemistry and Cell Biology in 2006.

Research Team

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