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Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
Principal Investigators
LIN Anning
Ph.D., Professor
Institute of Biochemistry and Cell Biology, SIBS, CAS, 320 Yue-yang Road, Shanghai 200031, China.
Email: alin@@sibcb.ac.cn

Research Interests
Signal transduction plays a pivot role in regulating cell functions, from proliferation, differentiation, programmed cell death, and transformation. Deregulation of signal transduction could lead to various human diseases even cancer. Extracellular signals are transmitted into cells via an intracellular signaling network that is composed of multiple signaling pathways, dictating cellular functions, such as growth, differentiation, programmed death (apoptosis) and transformation. Although we have learnt a great deal about the architecture of the intracellular signaling network, our understanding of its biology is limited. The work in my laboratory focuses on elucidating molecular mechanisms underlying plasticity and specificity of intracellular signaling network using c- Jun N-terminal protein kinase (JNK) and IkB kinase (IKK)/NF-kappaB as molecular probes and understanding the impact of deregulating the intracellular signaling network on human diseases and cancer (for more details, please see http://ben-may.bsd.uchicago.edu/faculty/lin.htm).

Selected Publications

  1. Lin A, Frost J, Deng T, Smeal T, Al-Alawi N, Kikkawa U, Hunter T, Brenner A, and Karin M. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell. 70:777-789, 1992.
  2. Hibi M, Lin A, Smeal T, Minden A, and Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes & Development 7:2135-2148, 1993.
  3. Minden A, Lin A, McMahon M, Lange-Carter, C, Derifard B, Davis R, Johnson G, and Karin M. Bifurcation in Ras signaling: Raf-1 and MEKK-1 differentially activate ERK and JNK MAP kinases. Science. 256:1719-1723, 1994.
  4. Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, and Karin M. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science. 268:286-290, 1995.
  5. Minden A, Lin A, Claret FX, Abo A, and Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cde42Hs. Cell. 81:1147-1157, 1995.
  6. Lu X, Nemoto S, and Lin A*. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. Journal of Biological Chemistry (Communication). 272:24751-24754, 1997.
  7. Nemoto S, DiDonato J A, and Lin A*. Coordinate regulation of IkB kinase by MEKK1 and NIK. Molecular and Cellular Biology . 18:7336-7343, 1998.
  8. Zheng C, Xiang J, Hunter T, and Lin A*. Generation of a constitutively active c-Jun N-terminal protein kinase that stimulates c-Jun transcription activity. Journal of Biological Chemistry. 274:28966-28971, 1999.
  9. Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, and Lin A*. Activation of NF-kB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proceedings of the National Academy of Science USA. 98:6668-6673, 2001.
  10. Tang G, Yang J, Minemoto Y, and Lin A*. Blocking caspase-3-mediated proteolysis of IKKb suppresses TNF-a-induced apoptosis. Molecular Cell. 8:1005-1016, 2001.
  11. Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, and Lin A*. Inhibition of JNK activation by NF-kB target genes. Nature. 414:313-317, 2001. - News and Views, Nature. 414:265-266, 2001; Highlights, Nature Reviews, 2: 875, 2001; Hot Papers, The Scientist, 12:32-33, 2003.
  12. Tang F, Tang G, Xiang J, Dai Q, Rosner MR, and Lin A*. Absence of NF-kB-mediated inhibition of JNK activation contributes to TNF-a induced apoptosis in MCF-7 cells. Molecular and Cellular Biology. 22:8571-8579, 2002.
  13. Karin M and Lin A. NF-kB at the crossroad of life and death. Nature Immunology. 3:221-227, 2002. - One of the most cited papers in the field, ISI.
  14. Lin A* and Dibling B. The true face of JNK activation in apoptosis. Aging Cell. 1:112-116, 2002.
  15. Lin A. Activation of the JNK signaling pathway: Breaking the Brake on Apoptosis. BioEssays. 25:17-24, 2003.
  16. Lin A*and Karin M. NF-kB in cancer: A marked target. Seminars in Cancer Biology. 13:107-114, 2003.
  17. Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui T, Xiang J*, and Lin A*. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Molecular Cell. 13:329-40, 2004.
  18. Liu J, Minemoto Y, and Lin A*. JNK1, but not JNK2, is essential for TNF-a-induced c-Jun kinase activation and apoptosis. Molecular and Cellular Biology. 24:10844-10856, 2004.
  19. Lin A. The role of JNK in apoptosis: A double-edged sword. In Anning Lin eds., The JNK signaling pathway. TX: Landers Bioscience. 63-69, 2006.
  20. Liu J, Yang D, Minemoto Y, Leitges M, Rosner M.R and Lin A*. NF-kB via PKCd promotes JNK activation by UV. Molecular Cell. 21:467-480, 2006.
  21. Lin, A. A Five-Year Itch for TNF-a Cytotoxicity: The Time Factor Determines JNK Action. Development Cell. 10:277-278, 2006.
  22. Liu J, and Lin A*. The NF-kB and JNK1 crosstalk: wiring the cell signaling circuitry in human diseases. Oncogene, 3267-3278, 2007.
  23. Liu J, Zhao Y, Eilers M, and Lin A*. Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-a-induced JNK1 activation. Proceedings of the National Academy of Science USA. 106(43):18279-84, 2009.
  24. Lin A*. ATIA: A Link between Inflammation and Hypoxia. Molecular Cell 42: 557-558, 2011.
  25. Liu J, Yan J, Jiang S, Wen J, Cheng L, Zhao Y, and Lin A*. Site-specific ubiquitination is required for relieving Miz1-mediated suppression on TNFα-induced JNK activation and inflammation. Proceedings of the National Academy of Science USA 109:191-6, 2012.
  26. Yan J, Xiang J, Lin Y, Ma J, Zhang J, Zhang H, Sun J, Danial N, Liu J, Lin A*. Inactivation of the BH3-only Protein BAD by IKK Inhibits TNFα-induced Apoptosis Independently of NF-κB Activation. Cell 152: 304-315, 2013.

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