Home CAS Center for Excellence
  
  
  

Faculty

Members of CAS, CAE
National Outstanding Young Scientists Award
Principal Investigators
 
Address: 320 Yue Yang Road, Shanghai 200031, P.R. China
Tel: 86-21-54920000
Fax: 86-21-54921011
Email: sibcb@sibs.ac.cn
Website: www.sibcb.ac.cn
 
Principal Investigators
 
ZHAO Yun
Ph.D., Professor
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
Email: yunzhao@@sibcb.ac.cn

Research Areas
fruit fly; cell differentiation and proliferation; Hedgehog (Hh); Smoothened (Smo); Cubitus interruptus (Ci); Fused (Fu)

Research Interests
How is cell growth controlled? How is cell fate determined? And, how does pattern form during animal development? These basic scientific questions are very critical in developmental biology. Cell-cell communication is a very important and fundamental mechanism for animal development. In many cases, the inductive signals, such as Hedgehog (Hh) and Wingless (Wnt), contribute to the cell-cell communication. Misregulation of cell signaling may cause diseases including cancers. Hh signaling pathway has been linked to several types of cancers including basal cell carcinomas. Induction signals are often highly conserved among organisms, such as between human being and Drosophila. Our long-term goal is to understand the mechanism of how cell growth and patterning are regulated. We will apply genetic, molecular and biochemical approaches to track new components in the Hh and related signaling pathways.

Selected Publications

  1. Lin Fu, Hailong Wu, Steven Y Cheng, Daming Gao, Lei Zhang and Yun Zhao*. Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway. eLIFE. 2016, 10.7554/eLife.15690. (*Corresponding author)
  2. Xiangdong Lv, Zhijun Han, Hao Chen, Bo Yang, Xiaofeng Yang, Yuanxin Xia, Chenyu Pan, Lin Fu, Shuo Zhang, Hui Han, Min Wu, Zhaocai Zhou, Lei Zhang, Lin Li, Gang Wei*, Yun Zhao*. A positive role for polycomb in transcriptional regulation via H4K20me1. Cell Research, 2016, 26:529-542. (*Corresponding author)
  3. Xiangdong Lv, Chenyu Pan, Zhao Zhang, Yuanxin Xia, Hao Chen, Shuo Zhang, Tong Guo, Hui Han, Haiyun Song, Lei Zhang, Yun Zhao*. SUMO regulates somatic cyst stem cells maintenance and directly targets Hedgehog pathway in adult Drosophila testis. Development, 2016, doi: 10.1242/dev.130773. [Epub ahead of print] (*Corresponding author)
  4. Shimin Wang, Yi Lu, Mengxin Yin, Chao Wang, Wei Wu, Jinhui Li, Wenqing Wu, Lianxin Hu, Yun Zhao and Lei Zhang. Importin α1 mediates Yorkie nuclear import via N-terminal non-canonical nuclear localization signal. Journal of Biological Chemistry, 2016, 291:7926-7937.
  5. Chao Wang, Meng-Xin Yin, Wei Wu, Liang Dong, Shimin Wang, Yi Lu, Jinjin Xu, Wenqing Wu, Sheng Li, and Yun Zhao and Lei Zhang. Taiman acts as a co-activator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration. Cell Discovery, 2016, 2, 16006
  6. Lianxin Hu, Jiajun Xu, Meng-Xin Yin, Liguo Zhang, Yi Lu, Wenqing Wu, Zhaoyu Xu, Margaret S. Ho, Guanjun Gao, Yun Zhao, Lei Zhang*. Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded. Cell Discovery, 2016, 2, 15047
  7. Hui Han, Jialin Fan, Yue Xiong, Wenqing Wu, Yi Lu, Lei Zhang, and Yun Zhao*. Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription. Scientific Reports. 2016, 6:18937. (*Corresponding author)
  8. Hui Wang, Zaijun Ma, Kongyan Niu, Yi Xiao, Xiaofen Wu, Chenyu Pan, Yun Zhao, Kai Wang, Yaoyang Zhang, and Nan Liu. Antagonistic roles between Nibbler and Hen1 modulate piRNA 3¨ ends in Drosophila. Development. 2016, 143(3):530-539.
  9. Chunying Liu, Yue Xiong, Jing Feng, Lei Zhang and Yun Zhao. Sqh is involved in the regulation of Ci stability in Hh signaling pathway. Journal of Molecular Cell Biology. 2015, 7:584-587.
  10. Liang Dong, Jinhui Li, Hongling Huang, Meng-Xin Yin, Jinjin Xu, Peixue Li, Yi Lu, Wenqing Wu, Hang Yang, Yun Zhao and Lei Zhang. Growth suppressor lingerer regulates bantam microRNA to restrict organ size. Journal of Molecular Cell Biology. 2015, 7(5):415-428.
  11. Qian Hao, Shi Jiao, Zhubing Shi, Chuanchuan Li, Xia Meng, Zhen Zhang, Yanyan Wang, Xiaomin Song, Wenjia Wang, Rongguang Zhang, Yun Zhao, Catherine CL Wong, and Zhaocai Zhou. A non\canonical role of the p97 complex in RIG\I antiviral signaling. The EMBO Journal. 2015, 34(23):2903-2920.
  12. Zhao Zhang, Yanyan Wang, Chuanchuan Li, Zhubing Shi, Qian Hao, Wenjia Wang, Xiaomin Song, Yun Zhao, Shi Jiao and Zhaocai Zhou. The transitional endoplasmic reticulum ATPase p97 regulates the alternative nuclear factor NF-κB signaling via partial degradation of the NF-κB subunit p100. Journal of Biological Chemistry. 2015, 290(32):19558-19568.
  13. Lin Fu, Xiangdong Lv, Yue Xiaong and Yun Zhao. Investigation of protein-protein interactions and conformational changes in Hedgehog signaling pathway by FRET. Methods in Molecular Biology, Hedgehog Signaling Protocols (Second Edition, Springer Science), Chapter 6. 2015, 1322:61-70.
  14. Zizhang Zhou, Xia Yao, Shuang Li, Yue Xiong, Xiaohua Dong, Yun Zhao#, Jin Jiang# and Qing Zhang#. Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog signaling. Developmental Cell. 2015, 34(1):58-72. (#Co-senior author)
  15. Hui Han, Chenyu Pan, Chunying Liu, Xiangdong Lv, Xiaofeng Yang, Yue Xiong, Yi Lu, Wenqing Wu, Junhai Han, Zhaocai Zhou, Hai Jiang, Lei Zhang and Yun Zhao. Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila. Cell Discovery. 2015, 1:15006.
  16. Chao Wang, Wenxiang Zhang, Meng-Xin Yin, Lianxin Hu, Peixue Li, Jiajun Xu, Hongling Huang, Shimin Wang, Yi Lu, Wenqing Wu, Margaret S. Ho, Lin Li, Yun Zhao and Lei Zhang. Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis. Nature Communications. 2015, 6:6607.
  17. Shi Jiao, Zhen Zhang, Chuanchuan Li, Min Huang, Zhubing Shi, Yanyan Wang, Xiaomin Song, Heng Liu, Chunyang Li, Min Chen, Wenjia Wang, Yun Zhao, Zhengfan Jiang, Hongyan Wang, Catherine C L Wong, Chen Wang and Zhaocai Zhou. The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. Nature Immunology. 2015, 16(3):246-257.
  18. Yue Xiong, Chunying Liu and Yun Zhao. Decoding Ci: From partial degradation to inhibition. Development, Growth & Differentiation. 2015, 57(2):98-108. (invited review)
  19. Chuanchuan Li, Miao Feng, Zhubing Shi, Qian Hao, Xiaomin Song, Wenjia Wang, Yun Zhao, Shi Jiao and Zhaocai Zhou. Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1. Journal of Biological Chemistry. 2014, 289(52):35969-35978.
  20. Lianxin Hu, Hongling Huang, Jinhui Li, Meng-xin Yin, Yi Lu, Wenqing Wu, Rong Zeng, Jin Jiang, Yun Zhao and Lei Zhang. Drosophila casein kinase 2 (CK2) promotes warts protein to suppress yorkie protein activity for growth control. Journal of Biological Chemistry. 2014, 289(48):33598-33607.
  21. Feifei Mao, Xiaofeng Yang, Lin Fu, Xiangdong Lv, Zhao Zhang, Wenqing Wu, Siqi Yang, Zhaocai Zhou, Lei Zhang and Yun Zhao. The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway. Journal of Biological Chemistry. 2014, 289(32):22333-22341.
  22. Cuicui Chen, Zhubing Shi, Wenqing Zhang, Min Chen, Feng He, Zhenzhen Zhang, Yicui Wang, Miao Feng, Wenjia Wang, Yun Zhao, Jerry H. Brown, Shi Jiao and Zhaocai Zhou. Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex. Journal of Biological Chemistry. 2014, 289(14):9651-9561.
  23. Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin Ji, Lei Zhang and Zhaocai Zhou. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014, 25(2):166-180.
  24. Hongling Huang, Jinhui Li, Lianxin Hu, Ling Ge, Hongbin Ji, Yun Zhao# and Lei Zhang#. Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling. Developmental Biology. 2014, 385(2):211-219. (#Corresponding author)
  25. Zuoyun Wang, Yihua Sun, Bin Gao, Yi Lu, Rong Fang, Yijun Gao, Tian Xiao, Xin-yuan Liu, William Pao, Yun Zhao#, Haiquan Chen# and Hongbin Ji#. Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome. Cancer Letters. 2014, 342(1):36-42. (#Corresponding author)
  26. Zhao Zhang, Jing Feng, Chenyu Pan, Xiangdong Lv, Wenqing Wu, Zhaocai Zhou, Feng Liu, Lei Zhang#, and Yun Zhao#. Atrophin/Rpd3 complex represses Hedgehog signaling by acting as a co-repressor of CiR. Journal of Cell Biology. 2013, 203(4):575-583. (#Corresponding author)
  27. Zhao Zhang, Xiangdong Lv, Wen Chi Yin, Xiaoyun Zhang, Jing Feng, Wenqing Wu, Chi-chung Hui, Lei Zhang#, and Yun Zhao#. Ter94 ATPase Complex Targets K11-linked Ubiquitinated Ci to Proteasomes for Partial Degradation. Developmental Cell. 2013, 25(6):636-644. (#Corresponding author)
  28. Shoujun Huang, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao#, and Dahua Chen#. Activation of Smurf E3 ligase promoted by Smoothened regulates Hedgehog signaling through targeting Patched turnover. PLoS Biology. 2013, 11(11):e1001721. (#Corresponding author)
  29. Yan Zhang, Lin Fu, Xiaolong Qi, Zhenyi Zhang, Yuanxin Xia, Jianhang Jia, Jin Jiang, Yun Zhao#, and Geng Wu#. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nature Communications. 2013, 4:2608 (#Corresponding author)
  30. Yunyun Jin, Jinjin Xu, Meng-Xin Yin, Yi Lu, Lianxin Hu, Peixue Li, Peng Zhang, Zengqiang Yuan, Margaret S Ho, Hongbin Ji, Yun Zhao#, and Lei Zhang#. Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling. eLIFE. 2013, 2:e00999. (#Corresponding author)
  31. Xiaofeng Yang, Feifei Mao, Xiangdong Lv, Zhao Zhang, Lin Fu, Yi Lu, Wenqing Wu, Zhaocai Zhou, Lei Zhang#, and Yun Zhao#. Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. Journal of Cell Science. 2013, 126(18):4230-4238. (#Corresponding author)
  32. Tong Guo, Yi Lu, Peixue Li, Mengxin Yin, Dekang Lv, Wenjing Zhang, Huizhen Wang, Zhaocai Zhou, Hongbin Ji, Yun Zhao#, and Lei Zhang#. A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell Research. 2013, 23(10):1201-1214. (#Corresponding author)
  33. Hong-Ling Huang, Shimin Wang, Meng-Xin Yin, Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao#, Xin-Yuan Liu#, Lei Zhang#. Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association. PLoS Biology. 2013, 11(8):e1001620. (#Corresponding author)
  34. Zhao Zhang#, Chenyu Pan, and Yun Zhao#. Hedgehog in the Drosophila testis niche: what does it do there? Protein and Cell. 2013, 4(9):650-655. (invited review) (#Corresponding author)
  35. Xiangdong Lv, Lin Fu, and Yun Zhao#. aPKC ι/λ: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC. Acta Biochimica et Biophysica Sinica. 2013, 45(7):610-611. (invited review) (#Corresponding author)
  36. Min Luo, Te Ling, Wenbing Xie, He Sun, Yonggang Zhou, Qiaoyun Zhu, Meili Shen, Le Zong, Guoliang Lyu, Yun Zhao, Tao Ye, Jun Gu, Wei Tao, Zhigang Lu, and Ingrid Grummt. NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells. Stem Cells. 2013, 31(7):1278-1286.
  37. Dawei Shi, Xiangdong Lv, Zhao Zhang, Xiaofeng Yang, Zhaocai Zhou, Lei Zhang#, and Yun Zhao#. Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction. Journal of Biological Chemistry. 2013, 288:12605-12614. (#Corresponding author)
  38. Zhao Zhang, Xiangdong Lv, Jin Jiang, Lei Zhang#, and Yun Zhao#. Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis. Cell Research. 2013, 23:573-576. (#Corresponding author)
  39. Zhubing Shi, Shi Jiao, Zhen Zhang, Miao Ma, Zhao Zhang, Cuicui Chen, Ke Wang, Huizhen Wang, Wenjia Wang, Lei Zhang, Yun Zhao#, and Zhaocai Zhou#. Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism. Structure. 2013, 21:449-461. (#Corresponding author)
  40. Meng Zhang, Liang Dong, Zhubing Shi, Shi Jiao, Zhen Zhang, Wenqing Zhang, Guogang Liu, Cuicui Chen, Miao Feng, Qian Hao, Wenjia Wang, Mengxin Yin, Yun Zhao, Lei Zhang, and Zhaocai Zhou. Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases. Structure. 2013, 21:680-688.
  41. Wenjia Wang, Zhubing Shi, Shi Jiao, Cuicui Chen, Huizhen Wang, Guoguang Liu, Qiang Wang, Yun Zhao, Mark I Greene, Zhaocai Zhou. Structural insights into SUN-KASH complexes across the nuclear envelope. Cell Research. 2012, 22:1440-1452.
  42. Shuo Shi, Yue-Zhen Deng, Jiang-Sha Zhao, Xiao-Dan Ji, Jun Shi, Yu-Xiong Feng, Guo Li, Jing-Jing Li, Di Zhu, H. Phillip Koeffler, Yun Zhao, Dong Xie. RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. Journal of Biological Chemistry. 2012, 287(11):7845-7858.
  43. Yunyun Jin, Liang Dong, Yi Lu, Wenqing Wu, Qian Hao, Zhaocai Zhou, Jin Jiang, Yun Zhao#, and Lei Zhang#. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. Journal of Biological Chemistry. 2012, 287:5784-5796. (#Corresponding author)
  44. Yanyan Zhang, Feifei Mao, Yi Lu, Wenqing Wu, Lei Zhang#, and Yun Zhao#. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Research. 2011, 21:1436-1451. (#Corresponding author)
  45. Yongbin Chen, Shuang Li, Chao Tong, Yun Zhao, Bing Wang, Yajuan Liu, Jianhang Jia, Jin Jiang. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes and Development. 2010, 24(18):2054-2067.
  46. Jun Yang, Xiaoqing Liu, Yun Zhao, Michael Adamian, Basil Pawlyk, Xun Sun, D. Randy McMillan, M. Charles Liberman, Tiansen Li. Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genetics. 2010, 6(5):e1000955.
  47. Joel M. Hyman, Ari J. Firestone, Vivi M. Heine, Yun Zhao, Cory A. Ocasio, Kyuho Han, Mark Sun, Paul G. Rack, Surajit Sinha, Jason J. Wu, David E. Solow-Cordero, Jin Jiang, David H. Rowitch, James K. Chen. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences USA. 2009, 106(33):14132-14137.
  48. Hongbo Yang, Jing Xiang, Nengdong Wang, Yun Zhao, Joel Hyman, Jin Jiang, James K. Chen, Zhen Yang and Shuo Lin. Converse conformational control of smoothened activity by structurally related small molecules. Journal of Biological Chemistry. 2009, 284(31):20876-20884.
  49. Yun Zhao, Chao Tong and Jin Jiang. Transducing the Hedgehog signal across the plasma membrane. Fly. 2007, 1(6):333-336. (invited review)
  50. Yun Zhao, Chao Tong and Jin Jiang. Hedgehog regulates Smoothened activity by inducing a conformational switch. Nature. 2007, 450:252-258. (Research Article)
  51. Jun Yang, Basil Pawlyk, Xiaohong Wen, Michael Adamian, Maria Soloviev, Norman Michaud, Yun Zhao, Michael A. Sandberg, Clint L. Makino, Tiansen Li. Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Human Molecular Genetics. 2007, 16(9):1017-1029.
  52. Xiaoqing Liu, Yun Zhao, Basil Pawlyk, Margot Damaser and Tiansen Li. Failure of Elastic Fiber Homeostasis Leads to Pelvic Floor Disorders. American Journal of Pathology. 2006, 168(2):519-528.
  53. Wensheng Zhang*, Yun Zhao*, Chao Tong, Gelin Wang, Bing Wang, Jianhang Jia, and Jin Jiang. Hedgehog-regulated Costal2/kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Developmental Cell. 2005, 8(2):267-278. (*equal contribution).
  54. Xiaoqing Liu, Yun Zhao, Jiangang Gao, Basil Pawlyk, Barry Starcher, Jeffrey A Spencer, Hiromi Yanagisawa, Jian Zuo and Tiansen Li. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nature Genetics. 2004, 36(2):178-182.
  55. Yun Zhao, Dong-Hyun Hong, Basil Pawlyk, Guohua Yue, Michael Adamian, Marcin Grynberg, Adam Godzik, and Tiansen Li. The retinitis pigmentosa GTPase Regulator (RPGR)-interacting protein: Subserving RPGR function and participating in disk morphogenesis. Proceedings of the National Academy of Sciences USA. 2003, 100(7):3965-3970.
  56. Yun Zhao, Zhigang Lu, Min Wu, Qingqing Han, Wei Tao, and Zhonghe Zhai. Effect of phosphocreatine on apoptosis induced in Xenopus cell-free system. Journal of Biological Chemistry. 2001, 276:34573-34578.
  57. Yun Zhao, Min Wu, Yan Shen, and Zhonghe Zhai. Analysis of nuclear apoptotic process in a cell-free system. Cellular and Molecular Life Science. 2001, 58:298-306.
  58. Yun Zhao, Yan Shen, Min Wu, and Zhonghe Zhai. The change of Nuclear Matrix Lamina in apoptosis of nucleus. J Chinese Electronic Microscope. 2001, 20(2):87-92.
  59. Min Wu, Yun Zhao, and Zhonghe Zhai. The ultrastructural observation of apoptotic mouse liver cell nuclei. Journal of Chinese Electronic Microscope. 2001, 20(1):21-26.
  60. Yun Zhao, Xiaoling Liu, Min Wu, Wei Tao, and Zhonghe Zhai. In vitro nuclear reconstitution could be induced in a plant cell-free system. FEBS Letters. 2000, 480:208-212.
  61. Zhengfan Jiang, Yun Zhao, Xia Hong, and Zhonghe Zhai. Nuclear apoptosis induced by isolated mitochondria. Cell Research. 2000, 10:221-232.
  62. Yun Zhao, Zhengfan Jiang, Yingli Sun, and Zhonghe Zhai. Apoptosis of mouse liver nuclei induced in the cytosol of carrot cells. FEBS Letters. 1999, 448:197-200.
  63. Yun Zhao, Yingli Sun, Zhengfan Jiang, and Zhonghe Zhai. Apoptosis of carrot nuclei in in vitro system induced by cytochrome c. Chinese Scince Bulletin. 1999, 44:1497-1501.
  64. Yingli Sun, Yun Zhao, Xia Hong, and Zhonghe Zhai. Cytochrome c release and caspase activation during menadione-induced apoptosis in plants. FEBS Letters. 1999, 462:317-321.
  65. Yingli Sun, Yun Zhao, Chunxiang Liu, and Zhonghe Zhai. Cytochrome c Can Induce Programmed Cell Death in Plant Cells. Acta Botanica Sinica. 1999, 41:379-383.
  66. Yingli Sun, Yun Zhao, Jian Wang, and Zhonghe Zhai. Distribution of NuMA-like Proteins and Its Changes During Cell-cycle in Plant cells. Acta Botanica Sinica. 1999, 41:235-240.
  67. Danying Chen, Yun Zhao, Dazhong Zhao, and Zhonghe Zhai. Study of intermediate filaments in Adiantum philippense and comparative analysis of karetin-like proteins in some plant species. Acta Botanica Sinica. 1998, 40:790-795.

Education Background & Academic Experience
1988-1992 B.S., Shandong University, Jinan, China.
1996-2001 Ph.D., College of Life Science, Peking University, China.
2001-2004 Postdoctoral Associate, Berman Gund Lab, Harvard Medical School, MA, U.S.A.2004-2008 Postdoctoral Fellow, Department of Developmental Biology, UT Southwestern Medical School, TX, U.S.A.
2008.10- present Principal Investigator, Shanghai Institute of Biochemistry and Cell Biology, CAS.

 

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