人才队伍

情况简介
院士风采
杰出青年
全所PI名录
 
 
地址:上海市岳阳路320号
邮编:200031
电话:86-21-54920000
传真:86-21-54921011
邮箱:sibcb@sibcb.ac.cn

全所PI名录 >

 
陈正军
研究员,研究组长,博士生导师
E-mail: zjchen@@sibcb.ac.cn


个人简介

1983毕业于第二军医大学;1989年获得国家教委青年奖学金赴德国学习;1993在德国乌尔姆大学获得博士学位,并在乌尔姆大学血液肿瘤研究所任博士后;1995年起在德国马普科学院生化所(Max-Planck-Institute of Biochemistry)历任博士后、高级研究人员和课题负责人。2001年3月作为”百人计划”入选者受聘于中科院上海生科院生物化学与细胞生物学研究所,任研究员,博士生导师。


研究方向

磷酸化蛋白质细胞信号网络与肿瘤发生


研究工作
细胞极性与细胞迁移、增殖和肿瘤发生的相关性研究:
        (1)生长因子受体信号通路调控的细胞极性蛋白酪氨酸磷酸化的生物学功能研究;
        (2)细胞极性蛋白复合物Par3-Par6-aPKC及其功能相关蛋白在上皮细胞极性中的功能研究;
        (3)研究Par蛋白复合物及其功能相关蛋白对细胞迁移,增殖及肿瘤发生发展中的影响;
        (4)研究其他RTKs在上皮细胞极性中的生物学意义。
        酪氨酸激酶细胞信号通路研究:
        (1)生长因子受体信号通路在肿瘤发生发展中的作用机理研究;
        (2)膜结合酪氨酸磷酸化蛋白功能分析及其跨膜信号转导作用机理研究;
        (3)胰岛素信号通路生物学功能及其在糖尿病发生中作用机理研究。
        磷酸化蛋白质组学研究:
        (1)磷酸化蛋白质组学技术方法的研究和发展;
        (2)肝癌磷酸化蛋白质组学研究;
        (3)肝癌发生发展过程中的蛋白质差异表达研究。


代表性论文

  1. Du D, Xu F, Yu L, Zhang C, Lu X, Yuan H, Huang Q, Zhang F, Bao H, Jia L, Wu X, Zhu X, Zhang X, Zhang Z, Chen Z*. The Tight Junction Protein, Occludin, Regulates the Directional Migration of Epithelial Cells. Development Cell. 2010, 18(1):52-63.
  2. Yuan H, Zhang H, Wu X, Zhang Z, Du D, Zhou S, Brakebusch C, and Chen Z*. Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice. Hepatology. 2009, 49:240-249.
  3. Lu XF, Feng XJ, Man XB, Yang G, Tang L, Du D, Zhang F, Yuan HX, Huang Q, Zhang Z, Liu YK, Strand D, and Chen Z*. Aberrant Splicing of Hugl-1, the Human Homologue of Drosophila Tumor Suppressor Gene lgl, is Associated with Hepatocellular Carcinoma Progression. Clin Cancer Res. 2009;15(10):3287-3296.
  4. Feng X, Lu X, Man X, Zhou W, Jiang LQ, Knyazev P, Lei L, Huang Q, Ullrich A, Zhang Z*, and Chen Z*. Overexpression of Csk binding protein (Cbp) contributes to renal cell carcinogenesis. Oncogene. 2009, 28(37):3320-31.
  5. Yang G, Li Q, Ren S, Lu X, Fang L, Zhou W, Zhang F, Xu F, Zhang Z, Zeng R, Lottspeich F, and Chen Z*. Proteomic, functional and motif-based analysis of C-terminal Src kinase-interacting proteins. Proteomics. 2009, 9(21):4944-61.
  6. Zhou W, Feng X, Wu Y, Benge J, Zhang Z, and Chen Z*. FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway. Cell Research. 2009, 19(10): 1165-1177.
  7. Ren S, Yang G, He Y, Wang Y, Li Y and Chen Z*. The conservation pattern of short linear motifs is highly correlated with the function of interacting protein domains. BMC Genomics. 2008, 9:452.
  8. Zhou Y, Fang L, Du D, Zhou W, Feng X, Chen J, Zhang Z, and Chen Z*. Proteome identification of binding-partners interacting with cell polarity protein Par3 in Jurkat cells. Acta Biochem Biochim Sin. 2008 Aug; 40(8):729-39.
  9. Fang L, Wang Y, Du D, Yang G, Kwok T, Kong S, Chen B, Chen D, Chen Z. Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair. Cell Research, 2007, 17(2):100-116
    (Highlights: A Polarity Protein Says Give Me a DNA Break. Cell, 2007, 128(3):419; The double (strand break) life of Par-3. Nature Cell Biology. 2007, 9(4):363-365.)
  10. Wang Y, Du D, Fang L, Zhang C, Yang G, Lottspeich F, Ullrich A, Chen Z. Tyrosine Phosphorylated Par3 Regulates Epithelial Tight Junction Assembly Promoted by EGFR Signaling. EMBO J. 2006, 5:5058-5070.
  11. Wang Y, Li R, Du D, Zhang C,Yuan H, Zeng R* and Chen Z*. Proteomic Analysis Reveals Novel Molecules Involved in Insulin Signaling Pathway. J Proteome Res. 2006, 5:846-855. (This paper is cited by JPR as a Featured Article)
  12. Lake Jiang Q, Feng X, Zhou W, Knyazev P, Ullrich A, Chen Z. Csk-binding protein(Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation. Oncogene. 2006, 25:5495-5506.
  13. Yuan H, Zhang L, Liu A, Zhou H, Wang Y, Zhang H, Wang G, Zeng R, Zhang Y*, Chen Z*. Proteomic profiling of regionalized proteins in rat epididymis indicates consistency between specialized distribution and protein functions. J. Proteome. Res. 2006, 5:299-307.
  14. Yao G, Chen W, Luo H, Jiang Q, Xia Z, Zang L, Zuo J, Wei X, Chen Z, Shen X, Dong C, Sun B. Identification of core functional region of murine IL-4 using peptide phage display and molecular modeling. Int Immunol. 2006, 18(1):19-29.
  15. Zong X, Eckert C, Yuan H, Wahl-Schott C, Abicht H, Fang L, Li R, Mistrik P, Gerstner A, Much B, Baumann L, Michalakis S, Zeng R, Chen Z*, Biel M*. A Novel Mechanism of Modulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channels by Src Kinase. J. Biol. Chem. 2005, 280(40): 34224-34232.
  16. Chen Z, Ullrich A. EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. Biol. Chem. 2003, 384(8):1215-26.
  17. Chen Z*, Kharitonenkov A*, Sures I, Wang H, and Ullrich A. A Family of Proteins that Inhibit Signaling through Tyrosine Kinase Receptors. Nature, 1997, 386: 181-186.

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