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宋建国

研究员，研究组长，博士生导师

电话：54921167
E-mail: jgsong@sibs.ac.cn

个人简介：
        1993年获美国纽约市立大学生化博士学位，在旧金山加州大学做博士后研究。1996年初起在中科院上海生化细胞所任现职。

研究方向：细胞分化与凋亡

研究工作：
        细胞增殖、凋亡和分化的信号传导机制。主要研究转化生长因子-beta在细胞增殖、凋亡和分化过程中的不同生物学效应及其相关的机制，包括其他因素或信号分子对转化生长因子-beta介导的生物学效应的调节作用。

代表性论文：

  1. Wang D, Zhou Y, Lei W, Zhang K, Shi J, Hu Y, Shu G, Song J (2010). Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor γ (PPARγ). Biology of the Cell 102, 1-12.
  2. Pan X, Wang X, Lei W, Min L, Yang Y, Wang X, Song J (2009). Nitric oxide suppresses transforming growth factor-β1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology 50, 1577-87.
  3. Zhang K, Tian H, Gao X, Lei W, Hu Y, Wang D, Pan X, Yu M, Xu G, Zhao F*, Song J (2009). Ferritin Heavy Chain–Mediated Iron Homeostasis and Subsequent Increased Reactive Oxygen Species Production Are Essential for Epithelial-Mesenchymal Transition. Cancer Res 69, 5340-48.
  4. Shi J, Wang D, Wang C, Hu Y, Liu A, Zhang Y, Sun B, Song J (2009). Insulin Receptor Substrate-1 Suppresses Transforming Growth Factor-{beta}1-Mediated Epithelial-Mesenchymal Transition. Cancer Res 69, 7180–7187.
  5. Tian H, Zhang K, Gao X, Lei W, Zhang L, Yu M, Song J*, Zhao F*. Comparative proteomic analysis of cell cycle-dependent apoptosis induced by transforming growth factor-beta. Biochim Biophys Acta 1794, 1387-1397.
  6. Zhang K, Wang D, Song J (2009). Cortactin is involved in transforming growth factor-β1-induced epithelial-mesenchymal transition in AML-12 cells. Acta Biochimica et Biophysica Sinica 41, 839–845.
  7. Y Yang, X Pan, W Lei, J Wang and J Song. (2006) Transforming growth factor-beta1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism. Oncogene. 25:7235-44
  8. Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li and Jianguo Song. (2006) Regulation of Transforming Growth Factor-{beta}1-Induced Apoptosis and Epithelial-to-Mesenchymal Transition by Protein Kinase A and Signal Transducers and Activators of Transcription 3. Cancer Res. 66:8617-24.
  9. Yiran Zhou, Dongmei Wang, Fuqiang Li, Jian Shi and Jianguo Song. Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation. Int J Biochem Cell Biol. 2006; 38:2151-63.
  10. Bo Zhou, Fuqiang Li, Hehua Chen and Jianguo Song. The modulation of apoptosis by cyclic AMP involves Akt and epidermal growth factor receptor. (2005) Int J Biochem Cell Biol. 37:1483-95.
  11. Sheng Zhao, Yanan Yang and Jianguo Song (2004). Ceramide induces caspase-dependent and -independent apoptosis in A-431 cells. J. Cell. Physiol. 199:47-56.
  12. Yanan Yang, Sheng Zhao, and Jianguo Song (2004). Caspase-dependent apoptosis and -independent poly(ADP-ribose) polymerase cleavage induced by transforming growth factor-α1. Int. J. Biochem. Cell Biol. 36:223-34.
  13. He-Hua Chen, Sheng Zhao and Jian-Guo Song (2003). TGF-α1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production. Cell Death and Differentiation. 10:320-331.
  14. Zhao S, Du X, Chen J, Zhou Y, Song J (2002). Secretory phospholipase A2 inhibits epidermal growth factor-induced receptor activation. Exp. Cell Res. 279:354-365.
  15. Sheng Zhao, Xiao-Yan Du, Min-Qiang Chai, Jun-Song Chen, Yuan-Chong Zhou and Jian-Guo Song (2002).Secretory phospholipase A2 induces apoptosis via a mechanism involving ceramide generation. BBA-Mol Biol Cell Lipids. 1581:75-88.
  16. Chai Min-Qiang, Chen Jun-Song, Zhao Sheng, Song Jian-Guo (2001). Propranolol increases phosphatidic acid level via phospholipase D activation. Acta Pharmacologica Sinica. 22 22:777-784.
  17. Jinhui Liao, Junsong Chen, Minqiang Chai, Sheng Zhao, and Jianguo Song (2001). The involvement of p38 MAPK in transforming growth factor beta 1-induced apoptosis in murine hepatocytes. Cell Research, 11:89-94.
  18. Junsong Chen and Jianguo Song (2001). Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells. IUBMB Life, 51:49-56.
  19. Binghong Zhou, Junsong Chen, Mingqiang Chai, Sheng Zhao, Jun Lian, Hehua Chen, and Jianguo Song (2000). Activation of phospholipase D activity in transforming growth factor-beta-induced cell growth inhibition. Cell Research, 10:139-149.
  20. Jun-Song Chen, Min-Qiang Chai, He-Hua Chen, Sheng Zhao and Jian-Guo Song (2000). Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells. BBA-Mol Biol Cell Lipids. 1488:219-232.