人才队伍

情况简介
院士风采
杰出青年
全所PI名录
 
 
地址:上海市岳阳路320号
邮编:200031
电话:86-21-54920000
传真:86-21-54921011
邮箱:sibcb@sibcb.ac.cn

全所PI名录 >

 
周斌
研究员,研究组长,博士生导师
E-mail: zhoubin@@sibcb.ac.cn


个人简介

2002年7月毕业于浙江大学医学院临床医学系,获得MD。2006年7月毕业于中国医学科学院中国协和医科大学,获得PhD。2006年至2010年在美国哈佛大学医学院波士顿儿童医院从事博士后研究。2009年任哈佛大学医学院讲师和Research Associate。2010年9月至2016年8月任中国科学院上海生命科学研究院营养科学研究所研究员,研究组长。2016年9月起任职于中国科学院上海生命科学研究院生物化学与细胞生物学研究所研究员,研究组长。曾获得中科院“百人计划”、国家杰出青年科学基金、国家万人计划“青年拔尖人才”及“领军人才”、ISHR杰出研究员奖、“英国皇家学会-牛顿高级学者基金”、中国青年科技奖、中国科学院青年科学家奖、谈家桢生命科学创新奖、树兰医学青年奖等。


研究方向

谱系示踪与细胞命运可塑性


研究工作

研究体内特定类型细胞的起源及命运,揭示细胞在发育、疾病和组织再生中的分化或转分化现象(细胞命运可塑性)及细胞命运调控机制具有重大的科学意义。研究组主要利用基于同源重组酶系统的遗传谱系追踪技术(图),在哺乳动物体内进行细胞标记及追踪来研究细胞的起源及命运。此外,研究组长期致力于谱系追踪新技术的开发及应用,并利用新技术更加深入探索哺乳动物体内细胞命运可塑性及其分子机制。
图:遗传谱系追踪技术的工作原理
 
       代表性研究成果多次在NatureScienceNat MedNat Genet等国际学术期刊发表,其中发现新生期心脏具有重新生成冠状动脉的能力入选“2014年度中国科学十大进展”。主要研究内容和方向如下:
        1、建立谱系追踪及遗传操作新技术,实现哺乳动物体内更为精准、高效的细胞追踪及遗传操作。
        2、利用遗传学、分子生物学、细胞生物学等手段,研究干细胞在器官发育与再生中功能及其细胞命运可塑性调控机理。
        3、利用新技术研究微环境及肿瘤细胞的起源、增殖、EMT及转移过程中的细胞及分子机制。
        4、结合合成生物技术与遗传学创建合成遗传学技术,利用人工合成信号通路实现哺乳动物体内细胞-细胞交流及其命运的解析及遗传调控。
     
        研究组朝气蓬勃,积极向上,团结进取,学术气氛活跃,致力于成为 “严谨、团结、创新”的谱系追踪与细胞命运可塑性研究团队。


代表性论文

  1.  Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng Y, Jing N, Peng G, Ji H, Zhou B*. Lung regeneration by multipotent stem cells residing at bronchioalveolar duct junction. Nat Genet 2019;doi.10.1038/s41588-019-0349-6.
  2. Yu W, Ma X, Xu J, Heumuller W, Fei Z, Feng X, Wang X, Liu K, Li J, Cui G, Peng G, Ji H, Li J, Jing N, Song H, Lin Z, Zhao Y, Wang Z, Zhou B*, Zhang L*. VGLL4 plays a critical role in heart valve development and homeostasis. PLos Genet 2019, in press.
  3. Han X, Wang Y, Pu W, Huang X, Qiu L, Li Y, Yu W, Zhao H, Liu X, He L, Zhang L, Ji Y, Lu J, Lui KO, Zhou B*. Lineage Tracing Reveals the Bi-potency of Sox9+ Hepatocytes during Liver Regeneration. Stem Cell Reports 2019; doi.10.1016/j.stemcr.2019.01.010
  4. Pu W, He L, Han X, Tian X, Li Y, Zhang H, Liu Q, Huang X, Zhang L, Wang QD, Yu Z, Yang X, Smart N, Zhou B*. Genetic Targeting of Organ-Specific Blood Vessels. Circ Res 2018;123:86-99.
  5. Tang J, Zhang H, He L, Huang X, Li Y, Pu W, Yu W, Zhang L, Cai D, Lui KO, Zhou B*. Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult Heart. Circ Res 2018;122:984-993.
  6. Zhang L, Issa Bhaloo S, Chen T, Zhou B*, Xu Q*. Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis. Circ Res 2018;122:1608-1624.
  7. Zhou B*, Wu SM*. Reassessment of c-Kit in Cardiac Cells: A Complex Interplay Between Expression, Fate, and Function. Circ Res 2018;123:9-11.
  8. Zhang H, Lui KO, Zhou B*. Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration. Circ Res 2018;122:774-789.
  9. Li Y, Lui KO, Zhou B*. Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases. Nat Rev Cardiol 2018;15:445-456.
  10. Li Y, He L, Huang X, Issa Bhaloo S, Zhao H, Zhang S, Pu W, Tian X, Li Y, Liu Q, Yu W, Zhang L, Liu X, Liu K, Tang J, Zhang H, Cai D, Adams RH, Xu Q, Lui KO, Zhou B*. Genetic Lineage Tracing of Non-Myocyte Population by Dual Recombinases. Circulation 2018;138:793-805.
  11. Tang J, Li Y, Huang X, He L, Zhang L, Wang H, Yu W, Pu W, Tian X, Nie Y, Hu S, Wang QD, Lui KO, Zhou B*. Fate Mapping of Sca1+ Cardiac Progenitor Cells in the Adult Mouse Heart. Circulation 2018;138:2967-2969.
  12. Li Y, Zhao H, Huang X, Tang J, Zhang S, Li Y, Liu X, He L, Ju Z, Lui KO, Zhou B*. Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth. Cell Res 2018;28:775-778.
  13. Zhao H, Tian X, He L, Li Y, Pu W, Liu Q, Tang J, Wu J, Cheng X, Liu Y, Zhou Q, Tan Z, Bai F, Xu F, Smart N, Zhou B*. Apj+ vessels drive tumor growth and represent a tractable therapeutic target. Cell Rep 2018;25:1241-1254.e5.
  14. Liu K, Yu W, Tang M, Tang J, Liu X, Liu Q, Li Y, He L, Zhang L, Evans SM, Tian X, Lui KO, Zhou B*. A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mesenchyme. Development 2018;145:dev167775.
  15. He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu WT, Zhou B*. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med 2017;23:1488-1498.
  16. He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, Miao X, Wang QD, Wang F, Chen T, Xu Q, Lui KO, Molkentin JD, Zhou B*. Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest 2017;127:2968-2981.
  17. Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang QD, Wu SM, Pu WT, Anderson RH, Zhou B*. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun 2017;8:87.
  18. Zhang H, Huang X, Liu K, Tang J, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO, Zhou B*. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Res 2017;27:1157-1177.
  19. He L, Zhou B*. Cardiomyocyte proliferation: remove brakes and push accelerators. Cell Res 2017;27:959-960.
  20. Zhang H, Pu W, Tian X, Huang X, He L, Liu Q, Li Y, Zhang L, He L, Liu K, Gillich A, Zhou B*. Genetic lineage tracing identifies endocardial origin of liver vasculature. Nat Genet 2016;48:537-543.
  21. Zhang H, Pu W, Liu Q, He L, Huang X, Tian X, Zhang L, Nie Y, Hu S, Lui KO, Zhou B*. Endocardium Contributes to Cardiac Fat. Circ Res 2016;118:254-265.
  22. Zhang H, Pu W, Li G, Huang X, He L, Tian X, Liu Q, Zhang L, Wu SM, Sucov HM, Zhou B*. Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls. Circ Res 2016;118:1880-1893.
  23. Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, Zhang L, Liu Q, Li Y, Li Y, Zhao H, Liu K, Lu J, Zhou Y, Huang P, Nie Y, Yan Y, Hui L, Lui KO, Zhou B*. Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration. Nat Commun 2016;7:13369.
  24. Liu Q, Yang R, Huang X, Zhang H, He L, Zhang L, Tian X, Nie Y, Hu S, Yan Y, Zhang L, Qiao Z, Wang QD, Lui KO, Zhou B*. Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes. Cell Res 2016;26:119-130.
  25. Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B*. GATA4 regulates Fgf16 to promote heart repair after injury. Development 2016;143:936-949.
  26. Liu Q, Huang X, Zhang H, Tian X, He L, Yang R, Yan Y, Wang QD, Gillich A, Zhou B*. c-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair. Nat Med 2015;21:866-868.
  27. Tian X, Pu WT, Zhou B*. Cellular Origin and Developmental Program of Coronary Angiogenesis. Circ Res 2015;116:515-530.
  28. Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T, Xu Q, Red-Horse K, Wythe JD, Zhou B*. Genetic targeting of sprouting angiogenesis using Apln-CreER. Nat Commun 2015;6:6020.
  29. Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P*. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature 2015;525:479-485.
  30. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, Zhou B*. De novo formation of a distinct coronary vascular population in neonatal heart. Science 2014;345:90-94.
  31. Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B*. Epicardium-to-fat transition in injured heart. Cell Res 2014;24:1367-1369.
  32. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans SM, Gittenberger-de Groot AC, Red-Horse K, Zhou B*. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res 2013;23:1075-1090.
  33. Zhou B*, Pu WT. Genetic Cre-loxP Assessment of Epicardial Cell Fate Using Wt1-Driven Cre Alleles. Circ Res 2012;111:e276-e280.
  34. Zhou B*, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise A, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest 2011;121:1894-1904.
  35. Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT*. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest 2009;119:1462-1476.
  36. Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT*. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 2008;454:109-113.

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