人才队伍

情况简介
院士风采
杰出青年
全所PI名录
 
 
地址:上海市岳阳路320号
邮编:200031
电话:86-21-54920000
传真:86-21-54921011
邮箱:sibcb@sibcb.ac.cn

全所PI名录 >

 
周斌
研究员,研究组长,博士生导师
E-mail: zhoubin@@sibcb.ac.cn


个人简介

2002年7月毕业于浙江大学医学院临床医学系,获得学士学位。2006年7月毕业于中国医学科学院中国协和医科大学,获得博士学位。2006年至2010年在美国哈佛大学医学院波士顿儿童医院从事博士后研究。2009年任哈佛大学医学院讲师和Research Associate。2010年9月至2016年8月任中国科学院上海生命科学研究院营养科学研究所研究员,研究组长。2016年9月起任职于中国科学院上海生命科学研究院生物化学与细胞生物学研究所研究员,研究组长。曾获得中科院“百人计划”(终期评估优秀)、基金委优秀青年科学基金及国家杰出青年科学基金、“英国皇家学会-牛顿高级学者基金”、中组部“国家万人计划-青年拔尖人才”及科技部“中青年科技创新领军人才”、中国青年科技奖、中国科学院青年科学家奖、谈家桢生命科学创新奖、树兰医学青年奖、上海市“浦江人才”、上海市青年科技英才、上海市领军人才、中科院“优秀导师”奖、“优秀研究生指导教师”奖、“朱李月华优秀教师”奖等奖项。


研究方向

谱系示踪与细胞命运可塑性


研究工作

        研究体内特定类型细胞的起源及命运,揭示细胞在发育、疾病和组织再生中的转分化现象(细胞命运可塑性)及细胞命运调控机制具有重大的科学意义。基于Cre-LoxP同源重组的传统遗传操作和示踪技术已经得到广泛应用,推动了细胞谱系建立和谱系变迁的研究。我们研究组长期致力于谱系示踪新技术研究,并利用新技术探索细胞命运可塑性及其分子机制,代表性研究成果多次在Nature、Science、Nat Med、Nat Genet等国际学术期刊发表,其中发现新生期心脏具有重新生成冠状动脉的能力入选“2014年度中国科学十大进展”。主要研究内容和方向如下:
        1、建立谱系示踪及遗传操作新技术,实现更为精准、高效的谱系示踪及遗传操作。
        2、利用遗传学、分子生物学、细胞生物学及计算生物学等手段,研究心脏发育与再生的细胞及分子机制。
        3、利用新技术研究血管内皮细胞特化及分化的分子机制,深入探索血脑屏障建立的细胞及分子基础。
        4、利用新技术研究器官发育与组织再生中(干)细胞的起源、分化命运、增殖、融合及衰老的机制。
        5、利用新技术研究肿瘤干细胞的起源、增殖及转移过程中的细胞机制。

       研究组朝气蓬勃,积极向上,团结进取,学术气氛活跃,致力于成为 “严谨、团结、创新”的谱系示踪与细胞命运可塑性研究团队。


代表性论文

  1. He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Nie Y, Hu S, Wang Q, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu W, Zhou B*. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med 2017; doi:10.1038/nm.4437.
  2. Zhang H, Huang X, Liu K, Tang J, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO, Zhou B*. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Res 2017;27:1157-1177.
  3. He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, Miao X, Wang QD, Wang F, Chen T, Xu Q, Lui KO, Molkentin JD, Zhou B*. Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest 2017;127:2968-2981.
  4. He L, Zhou B*. Cardiomyocyte proliferation: remove brakes and push accelerators. Cell Res 2017;27:959-960.
  5. Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang QD, Wu SM, Pu WT, Anderson RH, Zhou B*. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun 2017;8:87.
  6. Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT*, Chien KR*. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation 2017;135:59-72.
  7. Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH*. Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol 2017;19:189-201.
  8. Li G, Xu A, Sim S, Priest JR, Tian X, Khan T, Quertermous T, Zhou B, Tsao PS, Quake SR, Wu SM*. Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac Cells. Dev Cell 2016;39:491-507.
  9. Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, Zhang L, Liu Q, Li Y, Li Y, Zhao H, Liu K, Lu J, Zhou Y, Huang P, Nie Y, Yan Y, Hui L, Lui KO, Zhou B*. Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration. Nat Commun 2016;7:13369.
  10. Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B*. GATA4 regulates Fgf16 to promote heart repair after injury. Development 2016;143:936-949.
  11. He L, Liu Q, Hu T, Huang X, Zhang H, Tian X, Yan Y, Wang L, Huang Y, Miquerol L, Wythe JD, Zhou B*. Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovasc Res 2016;109:419-430.
  12. Zhang H, Pu W, Tian X, Huang X, He L, Liu Q, Li Y, Zhang L, He L, Liu K, Gillich A, Zhou B*. Genetic lineage tracing identifies endocardial origin of liver vasculature. Nat Genet 2016;48:537-543.
  13. Liu Q, Yang R, Huang X, Zhang H, He L, Zhang L, Tian X, Nie Y, Hu S, Yan Y, Zhang L, Qiao Z, Wang QD, Lui KO, Zhou B*. Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes. Cell Res 2016;26:119-130.
  14. Zhang H, Pu W, Liu Q, He L, Huang X, Tian X, Zhang L, Nie Y, Hu S, Lui KO, Zhou B*. Endocardium Contributes to Cardiac Fat. Circ Res 2016;118:254-265.
  15. Zhang H, Pu W, Li G, Huang X, He L, Tian X, Liu Q, Zhang L, Wu SM, Sucov HM, Zhou B*. Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls. Circ Res 2016;118:1880-1893.
  16. Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, Corada M, Dejana E, Zhou B, Adams RH*. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nat Commun 2016;7:12422.
  17. Mondor I, Jorquera A, Sene C, Adriouch S, Adams RH, Zhou B, Wienert S, Klauschen F, Bajénoff M*. Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature Remodeling. Immunity 2016;45:877-888.
  18. Lu A, Zuo C, He Y, Chen G, Piao L, Zhang J, Xiao B, Shen Y, Tang J, Kong D, Alberti S, Chen D, Zuo S, Zhang Q, Yan S, Fei X, Yuan F, Zhou B, Duan S, Yu Y, Lazarus M, Su Y, Breyer RM, Funk CD, Yu Y*. EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling. J Clin Invest 2015;125:1228-1242.
  19. Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P*. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature 2015;525:479-485.
  20. Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T, Xu Q, Red-Horse K, Wythe JD, Zhou B*. Genetic targeting of sprouting angiogenesis using Apln-CreER. Nat Commun 2015;6:6020.
  21. Tian X, Pu WT, Zhou B*. Cellular Origin and Developmental Program of Coronary Angiogenesis. Circ Res 2015;116:515-530.
  22. Liu Q, Huang X, Zhang H, Tian X, He L, Yang R, Yan Y, Wang QD, Gillich A, Zhou B*. c-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair. Nat Med 2015;21:866-868.
  23. Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, Seidman CE, Seidman JG, Pu WT, Wang DZ*. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest 2015;125:4122-4134.
  24. Chen HI, Poduri A, Numi H, Kivela R, Saharinen P, McKay AS, Raftrey B, Churko J, Tian X, Zhou B, Wu JC, Alitalo K, Red-Horse K*. VEGF-C and aortic cardiomyocytes guide coronary artery stem development. J Clin Invest 2014;124:4899-4914.
  25. Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, Schuetz JD, Malicki J, Zhong TP*. Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nat Cell Biol 2014;16:841-851.
  26. Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL, Camargo FD, Pu WT, Zhou B*. Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion. J Biol Chem 2014;289:18681-18692.
  27. Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, Yau AL, Buck JN, Gouin KA, van Gorp PR, Zhou B*, Chen J, Seidman JG, Wang DZ, Pu WT. Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model. Circ Res 2014;115:354-363.
  28. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, Zhou B*. De novo formation of a distinct coronary vascular population in neonatal heart. Science 2014;345:90-94.
  29. Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B*. Epicardium-to-fat transition in injured heart. Cell Res 2014;24:1367-1369.
  30. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans SM, Gittenberger-de Groot AC, Red-Horse K, Zhou B*. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res 2013;23:1075-1090.
  31. von Gise A, Lin Z, Schlegelmilch K, Honor LB, Pan GM, Buck JN, Ma Q, Ishiwata T, Zhou B, Camargo FD, Pu WT*. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A 2012;109:2394-2399.
  32. Zhou P, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D, Pu WT*. Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A 2013;110:15395-15400.
  33. Zhou B*, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT*. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol 2012;52:43-47.
  34. Zhou B*, Pu WT*. Genetic Cre-loxP Assessment of Epicardial Cell Fate Using Wt1-Driven Cre Alleles. Circ Res 2012;111:e276-e280.
  35. Chauhan D, Tian Z, Nicholson B, Kumar KG, Zhou B, Carrasco R, McDermott JL, Leach CA, Fulcinniti M, Kodrasov MP, Weinstock J, Kingsbury WD, Hideshima T, Shah PK, Minvielle S, Altun M, Kessler BM, Orlowski R, Richardson P, Munshi N, Anderson KC*. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell 2012;22:345-358.
  36. Smart N, Bollini S, Dube KN, Vieira JM, Zhou B, Davidson S, Yellon D, Riegler J, Price AN, Lythgoe MF, Pu WT, Riley PR*. De novo cardiomyocytes from within the activated adult heart after injury. Nature 2011;474:640-644.
  37. Chong JJ, Chandrakanthan V, Xaymardan M, Asli NS, Li J, Ahmed I, Heffernan C, Menon MK, Scarlett CJ, Rashidianfar A, Biben C, Zoellner H, Colvin EK, Pimanda JE, Biankin AV, Zhou B, Pu WT, Prall OW, Harvey RP*. Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin. Cell Stem Cell 2011;9:527-540.
  38. Zhou B*, von Gise A, Ma Q, Hu YW, Pu WT*. Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol 2010;338:251-261.
  39. Zhou B*, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise A, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT*. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest 2011;121:1894-1904.
  40. Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT*. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest 2009;119:1462-1476.
  41. Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT*. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 2008;454:109-113.

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