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院士风采
杰出青年
全所PI名录
 
 
地址:上海市岳阳路320号
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全所PI名录 >

 
邹卫国
研究员,研究组长,博士生导师
E-mail: zouwg94@@sibcb.ac.cn


个人简介

1998年本科毕业于南开大学生物化学系,2003年中科院生物化学与细胞生物学研究所获得理学博士学位。随后在美国Scripps研究所和美国哈佛大学公共卫生学院进行博士后研究(受美国白血病淋巴瘤协会资助)。2009年获选哈佛大学公共卫生学院Yerby Fellow。2012年获聘美国康纳尔大学和纽约州立大学布法罗分校Tenure Track助理教授职位。2012年8月回中科院生物化学与细胞生物学研究所工作,任研究员,研究组长,博士生导师。获得国家自然科学基金委杰出青年科学基金资助,国家科技部基础科学重大研究计划子课题负责人,中国科学院战略性先导科技专项(B类)子课题负责人,中华医学会骨科分会再生医学青年委员会组长,中华医学会骨矿盐与骨质疏松分会基础组常委,中国生物工程学会转化医学分会常委等。


研究方向

间充质干细胞与疾病


研究工作

间充质干细胞(mesenchymal stem cells,MSC)是一种多能干细胞,可以分化成成骨细胞、软骨细胞、脂肪细胞、肌肉细胞等。同时,间充质干细胞来源方便,易于分离、培养、扩增和纯化,可以作为组织器官损伤修复的种子细胞。间充质干细胞是国内外用于干细胞临床试验使用最多的细胞。间充质干细胞向不同组织细胞的分化受到多种遗传因素和表观遗传因素的影响,受到包括BMP、Wnt、Hedgehog等多种信号途径的调控。调控因素的异常,导致多种疾病,包括多种先天性发育畸形、骨质疏松症、骨性关节炎等骨科相关疾病。
 
本研究组综合运用生物化学、分子生物学和动物模型等多种研究手段,通过建立间充质干细胞向多种细胞分化的体外高通量筛选系统,研究间充质干细胞增殖与分化的分子机理,以及构建转基因与基因敲除小鼠研究与间充质干细胞相关的多种疾病的致病机理。实验室近期研究方向包括:
1)研究间充质干细胞所受到的表观调控在骨关节炎、骨质疏松及骨损伤修复过程中的作用。
2)研究间充质干细胞的衰老与骨疾病的关联及分子基础。
3)研究机械力对于间充质干细胞功能及骨结构的调控机制。
4)研究骨损伤修复中间充质干细胞的起源、增殖及命运决定的机制。


代表性论文

1.Han Y, You X, Xing W, Zhang Z, Zou W*. (2018) Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Research. May 24; 6:16.
2.Sun J, Ermann J, Niu N, Yan G, Yang Y, Shi Y, Zou W*. (2018) Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Research. Apr 26; 6:14.
3.Dai Q, Xu Z, Ma X, Niu N, Zhou S, Xie F, Jiang L, Wang J*, Zou W*.(*corresponding author) (2017) mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression. Cell Death and Differentiation 24, 1886–1899.
4.Dai Q, Xie F, Han Y, Ma X, Zhou S, Jiang L*, Zou W.* Wang J*.(2017)Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice. The Journal of Biological Chemistry. VOL. 292, NO. 1, pp. 196–204.
5. Xu Z, Greenblatt MB, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher LH, Zou W*. (2017) SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nature Communications 8:14570.
6.Niu N, Xiang JF, Yang Q, Wang L, Wei Z, Chen LL, Yang L, Zou W*. (2017) RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression. Cell Discovery 3, 16050.
7.Niu N, Shao R, Yan G, Zou W*. (2016) Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth. The Journal of Biological Chemistry VOL. 291, NO. 52, pp. 26647–26657.
8.Liu J, Wan L, Liu J, Yuan Z, Zhang J, Guo J, Malumbres M, Liu J*, Zou W*, Wei W*.(2016)Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discovery, 2, 15044.
9.Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L*, Wei W*, Zou W*. (2016) Cdh1 regulates Craniofacial Development via APC-dependent Activation of Goosecoid. Cell Research, 26:699-712.
10.Liu Z, Yao X, Yan G, Xu Y, Yan J, Zou W*, Wang G*.(2016) Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nature Communications,7: 11149.
11.Zou, W*, Greenblatt, M.B., Brady, N., Lotinun, S., Zhai, B., de Rivera, H., Singh, A., Sun, J., Gygi, S.P., Baron, R., Glimcher, L.H., Jones, D.C.(2013) The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. J Exp Med. 210, 1793-806.
12.Zou, W., Chen, X., Shim, J.H., Huang, Z., Brady N., Hu, D.Z, Drapp, R., Sigrist, K., Glimcher, L.H. and Jones, D.C. (2011) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13, 59–65.
13.Zou, W.*, Greenblatt, M.B.* (*co-first author), Shim, J.H., Kant, S., Zhai, B., Brady, B., Hu, D.Z., Gygi, S.P., Davis, R., Jones, D.C. and Glimcher, L.H. (2011) MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1. J ClinInvest . 121, 4383-92.
14.Wan, L.*, Zou, W.* (*co-first author), Gao, D., Inuzuka, H., Drapp, R., Shaik, S., Eguren, M., Hu, D.Z., Malumbres, M., Glimcher L.H. and Wei W. (2011) Cdh1 Regulates Osteoblast functions through an APC/C-independent modulation of Smurf1. Molecular Cell. 44, 721-33.
15.Shim, J.H, Greenblatt, M.B., Zou, W., Huang, Z., Wein, M.N., Brady N., Hu, D., Charron, J., Brodkin, H.R., Petsko, G.A., Zaller, D., Zhai, B., Gygi, S., Glimcher, L.H., Jones, D.C. (2013) Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 123:4010-22.
16.Greenblatt, M.B., Shim, J.H., Zou, W., Sitara, D., Schweitzer, M., Hu, D., Lotinun, S., Sano, Y., Baron, R., Park, J.M., Arthur, S., Xie, M., Schneider, M.D., Zhai, B., Gygi, S., Davis, R., Glimcher, L.H. (2010) The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 120, 2457-73.
17.Shim J,H., Greenblatt, M.B., Xie, M., Schneider, M.D., Zou, W., Zhai, B., Gygi, S., Glimcher, L.H. (2009) TAK1 is an essential regulator of BMP ignaling in cartilage. EMBO J. 28, 2028-41.
18.Zou, W., Kim, J.H., Handidu, A., Li, X., Kim, K.I., Yan, M., Li, J., Zhang D.E. (2007). Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages. BiochemBiophys Res Commun. 356, 193-9.
19.Zou,W., Wang, J., and Zhang,D.E. (2007). Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. BiochemBiophys Res Commun., 354, 321-327.
20.Okumura, F., Zou, W., and Zhang, D.E. (2007).ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. Genes Dev., 21, 255 – 260.
21.Malakhova, O.A., Kim, K.I., Luo, J.K., Zou, W., Kumar, K.G., Fuchs, S.Y., Shuai, K., Zhang, D.E. (2006) UBP43 is a novel regulator of interferon signaling independent of its ISG15isopeptidase activity. EMBO J. 25, 2358-2367.
22.Zou,W. and Zhang,D.E. (2006). The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. J Biol. Chem. 281, 3989-3994.
23.Kim, K.I., Yan, M., Malakhova, O., Luo, J.K., Shen, M.F., Zou, W., de la Torre, J.C., Zhang, DE. (2006). Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol Cell Biol. 26, 472-479.
24.Zou,W., Papov,V., Malakhova,O., Kim,K.I., Dao,C., Li,J., and Zhang,D.E. (2005). ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin. Biochem. Biophys. Res. Commun. 336, 61-68.
25.Liu, X., Qiu, S., Zou, W., Pei, Z., Gu, J., Luo, C., Ruan, H., Chen, Y., Qi, Y., Qian, C.. (2005) Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5. MolTher. 11, 531-541.
26.Zhang, Z., Zou, W., Wang, J., Gu, J., Dang, Y., Li, B., Zhao, L., Qian, C., Qian, Q., Liu, X. (2005) Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, soluble Flt-1. MolTher. 11, 553-562.
27.Zou,W., Luo,C., Zhang,Z., Liu,J., Gu,J., Pei,Z., Qian,C., and Liu,X. (2004). A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent antitumoral efficiency. Oncogene 23, 457-464.
28.Xu, W., Yu, F., Yan, M., Lu, L., Zou, W., Sun, L., Zheng, Z., Liu, X. (2004). Geldanamycin, a heat shock protein 90-binding agent, disrupts Stat5 activation in IL-2-stimulated cells. J Cell Physiol. 198, 188-96.
29.Pei, Z., Chu, L., Zou, W., Zhang, Z., Qiu, S., Qi, R., Gu, J., Qian, C., Liu, X. (2004) An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice. Hepatology. 39, 1371-1381.
30.Zhang, Z*, Zou,W* (*co-first author), Luo,C., Li,B., Wang,J., Sun,L., Qian,Q., and Liu,X. (2003). An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy. Cell Res. 13, 481-489.
31.Zou,W*., Zeng,J.* (*co-first author), Zhuo,M., Xu,W., Sun,L., Wang,J., and Liu,X. (2002). Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells. J Neurosci. Res. 67, 837-843.
32.Zou,W., Wang,D., Lang,M., Jin,D., Xu,D., Zheng,Z., Wu,Z., and Liu,X. (2002). Human interleukin 10 gene therapy decreases the severity and mortality of lethal pancreatitis in rats. J Surg. Res. 103, 121-126.
33.Liu,J., Zou,W., Lang,M., Luo,J., Sun,L., Wang,X., Qian,Q., and Liu,X. (2002). Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. Int. J Oncol. 21, 661-666.
34.Zou,W., Yan,M., Xu,W., Huo,H., Sun,L., Zheng,Z., and Liu,X. (2001). Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. J Neurosci. Res. 64, 646-653.

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