人才队伍

情况简介
院士风采
杰出青年
全所PI名录
 
 
地址:上海市岳阳路320号
邮编:200031
电话:86-21-54920000
传真:86-21-54921011
邮箱:sibcb@sibcb.ac.cn

全所PI名录 >

 
李党生
研究员,Cell Research常务副主编,Cell Discovery执行主编
E-mail: dsli@@sibs.ac.cn


个人简介

1988年毕业于中国科技大学,1995年在美国康奈尔大学医学院获得博士学位。 1996年至2004年在纽约大学医学中心做博士后。2004年至2006年任Cell杂志的Associate Editor。2006年至今担任Cell Research 常务副主编, 2015年负责创办Cell Discovery并担任执行主编。曾以第一作者或共同作者身份在 Cell, Cell Host & Microbe, Cell Research, Cell Stem Cell, Developmental Cell, EMBO Journal, Genes & Development, Journal of Biological Chemistry, Molecular and Cellular Biology, Nature, Nature Immunology, Science Signaling等杂志上发表论文或评述50余篇。2007年入选上海浦江人才计划;2008年入选首批全国新闻出版行业领军人才;2009年至2010年获中科院文献情报与出版行业引进人才择优支持; 2011年入选全国宣传文化系统“四个一批”人才; 2012年获“上海出版人奖”, 2012年获谈家桢生命科学创新奖, 2013年获国务院政府特殊津贴, 2013年获中国出版政府奖。


研究方向

Cell Research常务副主编,Cell Discovery执行主编


代表性论文

  1. Gou LT, Kang JY, Dai P, Wang X, Li F, Zhao S, Zhang M, Hua MM, Lu Y, Zhu Y, Li Z, Chen H, Wu LG, Li D, Fu XD, Li J, Shi HJ, Liu MF. Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell 169: 1090-1104 (2017)
  2. Yuan P, He XH, Rong YF, Cao J, Li Y, Hu YP, Liu Y, Li D, Lou W, Liu MF. KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis. Cancer Res. 77: 100-111 (2017)
  3. Li Y, Han J, Zhang Y, Cao F, Liu Z, Li S, Wu J, Hu C, Wang Y, Shuai J, Chen J, Cao L, Li D, Shi P, Tian C, Zhang J, Dou Y, Li G, Chen Y, Lei M. Structural basis for activity regulation of MLL family methyltransferases. Nature 530: 447-452 (2016)
  4. Li D. Sanofi-Cell Research outstanding paper award of 2014. Cell Res. 25: 1179-1180 (2015)
  5. Zhang LF, Lou JT, Lu MH, Gao C, Zhao S, Li B, Liang S, Li Y, Li D, Liu MF. Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma. EMBO J. 34: 2671-2685 (2015)
  6. Ju X, Yan Y, Liu Q, Li N, Sheng M, Zhang L, Li X, Liang Z, Huang F, Liu K, Zhao Y, Zhang Y, Zou Z, Du J, Zhong Y, Zhou H, Yang P, Lu H, Tian M, Li D, Zhang J, Jin N, Jiang C. Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture. J Virol. 89: 10347-10358 (2015)
  7. Zhong C, Yin Q, Xie Z, Bai M, Dong R, Tang W, Xing YH, Zhang H, Yang S, Chen LL, Bartolomei MS, Ferguson-Smith A, Li D, Yang L, Wu Y1, Li J. CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library. Cell Stem Cell 17: 221-32 (2015)  
  8. Liu B, Sun L, Liu Q, Gong C, Yao Y, Lv X, Lin L, Yao H, Su F, Li D, Zeng M, Song E. A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. Cancer Cell 27: 370-381 (2015)
  9. Li D. Cell Discovery: A new publishing experience. Cell Discov. doi: 10.1038/celldisc.2015.9. (2015)
  10. Zhang F, Xu L, Xu L, Xu Q, Li D, Yang Y, Karsenty G, Chen CD. JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice. J Mol Cell Biol. 7: 23-34 (2015)
  11. Li D. Sanofi-Cell Research Outstanding Paper Award of 2013. Cell Res. 24:1279 (2014)
  12. Sheng M, Zhong Y, Chen Y, Du J, Ju X, Zhao C, Zhang G, Zhang L, Liu K, Yang N, Xie P, Li D, Zhang MQ, Jiang C. Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro. Sci China Life Sci. 57: 959-972 (2014)
  13. Zhang M, Zhou H, Zheng C, Xiao J, Zuo E, Liu W, Xie D, Shi Y, Wu C, Wang H, Li D, Li J. The roles of testicular c-kit positive cells in de novo morphogenesis of testis. Sci Rep. doi: 10.1038/srep05936 (2014)
  14. Wang L, Zhang LF, Wu J, Xu SJ, Xu YY, Li D, Lou JT, Liu MF. IL-1β-mediated repression of microRNA-101 is crucial for inflammation-promoted lung tumorigenesis. Cancer Res. 74: 4720-4730 (2014)
  15. Huang F, Guo J, Zou Z, Liu J, Cao B, Zhang S, Li H, Wang W, Sheng M, Liu S, Pan J, Bao C, Zeng M, Xiao H, Qian G, Hu X, Chen Y, Chen Y, Zhao Y, Liu Q, Zhou H, Zhu J, Gao H, Yang S, Liu X, Zheng S, Yang J, Diao H, Cao H, Wu Y, Zhao M, Tan S, Guo D, Zhao X, Ye Y, Wu W, Xu Y, Penninger JM, Li D, Gao GF, Jiang C, Li L. Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nat Commun. doi: 10.1038/ncomms4595 (2014)
  16. Zou Z, Yan Y, Shu Y, Gao R, Sun Y, Li X, Ju X, Liang Z, Liu Q, Zhao Y, Guo F, Bai T, Han Z, Zhu J, Zhou H, Huang F, Li C, Lu H, Li N, Li D, Jin N, Penninger JM, Jiang C. Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nat Commun. 10.1038/ncomms4594 (2014)
  17. Zhang Y., Y. Lu, L. Ma, X. Cao, J. Xiao, J. Chen, S. Jiao, Y. Gao, C. Liu, Z. Duan, D. Li, Y. He, B. Wei, and H. Wang. Activation of Vascular Endothelial Growth Factor Receptor-3 in Macrophages Restrains TLR4-NF-κB Signaling and Protects against Endotoxin Shock. Immunity 40: 501-514 (2014)
  18. Lin J., R. Huo, L. Xiao, X. Zhu, J. Xie, S. Sun, Y. He, J. Zhang, Y. Sun, Z. Zhou, P. Wu, B. Shen, D. Li, and N. Li. A novel p53/microRNA-22/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis. Arthritis Rheumatol. 66: 49-59 (2014)
  19. Wu Y., D. Liang, Y. Wang, M. Bai, W. Tang, S. Bao, Z. Yan, D. Li, and J. Li. Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell 13: 659-662 (2013)
  20. Li D. Sanofi-Cell Research outstanding paper award of 2012. Cell Res. 23: 1241 (2013)
  21. Yao X., D. Li, and G. Pei. In focus: molecular and cell biology research in China. Nat Rev Mol Cell Biol. 14: 600-606 (2013)
  22. Zeng A., Y.Q. Li, C. Wang, X.S. Han, G. Li, J.Y. Wang, D. Li, Y.W. Qin, Y. Shi, G. Brewer, and Q. Jing. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. J Cell Biol. 201: 409-425 (2013)
  23. Cui L., Y. Guan, Z. Qu, J. Zhang, B. Liao, B. Ma, J. Qian, D. Li, W. Li, G.T. Xu, and Y. Jin. WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors. J Clin Invest. 123: 1647-1661 (2013)
  24. Zhao S., L.T. Gou, M. Zhang, L.D. Zu, M.M. Hua, Y. Hua, H.J. Shi, Y. Li, J. Li, D. Li, E.D. Wang, and M.F. Liu. piRNA-Triggered MIWI Ubiquitination and Removal by APC/C in Late Spermatogenesis. Dev Cell 24: 13-25 (2013)
  25. Li D. The 2013 special issue on stem cell biology. Cell Res. 23: 1-2 (2013)
  26. Li D. Sanofi-cell research outstanding paper award of 2011. Cell Res. 22: 1511 (2012)
  27. Yin J.W., Y. Liang, J.Y. Park, D. Chen, X. Yao, Q. Xiao, Z. Liu, B. Jiang, Y. Fu, M. Bao, Y. Huang, Y. Liu, J. Yan, M.S. Zhu, Z. Yang, P. Gao, B. Tian, D. Li, and G. Wang. Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev. 26: 2192-2205 (2012)
  28. Lin J., Z. Zhou, R. Huo, L. Xiao, G. Ouyang, L. Wang, Y. Sun, B. Shen, D. Li, and N. Li. Cyr61 Induces IL-6 Production by Fibroblast-like Synoviocytes Promoting Th17 Differentiation in Rheumatoid Arthritis. J Immunol. 188: 5776-5784 (2012)
  29. Yang H., L. Shi, B.A. Wang, D. Liang, C. Zhong, W. Liu, Y. Nie, J. Liu, J. Zhao, X. Gao, D. Li, G.L. Xu, and J. Li. Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. Cell 149: 605-617 (2012)
  30. Sun Y., C. Li, Y. Shu, X. Ju, Z. Zou, H. Wang, S. Rao, F. Guo, H. Liu, W. Nan, Y. Zhao, Y. Yan, J. Tang, C. Zhao, P. Yang, K. Liu, S. Wang, H. Lu, X. Li, L. Tan, R. Gao, J. Song J, X. Gao, X. Tian, Y. Qin, K.F. Xu, D. Li, N. Jin, and C. Jiang. Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection. Sci Signal. 21: 5(212):ra16 (2012)
  31. Jiang S., L.F. Zhang, H.W. Zhang, S. Hu, M.H. Lu, S. Liang, B. Li, Y. Li, D. Li, E.D. Wang, and M.F. Liu. A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. EMBO J. 31: 1985-1998 (2012)  
  32. *Li D. A special issue on cell signaling, disease, and stem cells. Cell Res. 22: 1-2 (2012)
  33. Deng Y.Z., D. Yao, J.J. Li, Z.F. Mao, P.T. Hu, L.Y. Long, G. Li, X.D. Ji, S. Shi, D.X. Guan, Y.Y. Feng, L. Cui, D. Li, Y. Liu, X. Du, M.Z. Guo, L.Y. Xu, E.M. Li, H.Y. Wang, and D. Xie. RACK1 Suppresses Gastric Tumorigenesis by Stabilizing the β-Catenin Destruction Complex. Gastroenterology 142: 812-823  (2012)
  34. *Li D. Sanofi-Cell Research Outstanding Paper Award of 2010. Cell Res. 21: 1521-1522 (2011)
  35. Yang N., X. Hong, P. Yang, X. Ju, Y. Wang, J. Tang, C. Li, Q. Fan, F. Zhang, Z. Chen, L. Xing, Z. Zhao, X. Gao, G. Liao, Q. Li, X. Wang, D. Li, and C. Jiang. The 2009 pandemic A/Wenshan/01/2009 H1N1 induces apoptotic cell death in human airway epithelial cells.  J. Mol. Cell Biol. 3: 221-229 (2011).
  36. Lin J., L. Shi, M. Zhang, H. Yang, Y. Qin, J. Zhang, D. Gong, X. Zhang, D. Li, and J. Li. Defects in trophoblast cell lineage account for the impaired in vivo development of cloned embryos generated by somatic nuclear transfer. Cell Stem Cell 8: 371-375 (2011).
  37. Zhang Q., J. Wu, Q. Cao, L. Xiao, L. Wang, D. He, G. Ouyang, J. Lin, B. Shen, Y. Shi, Y. Zhang, D. Li, and N. Li. A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum. 60: 3602-3612 (2009).
  38. Huang J., T. Chen, X. Liu, J. Jiang, J. Li, D. Li, X.S. Liu, W. Li, J. Kang, and G. Pei. More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells. Cell Res. 19: 1127-1138 (2009).
  39. *Li, D. JMCB: From China, for the world. J. Mol. Cell Biol. 1: 1-2 (2009)
  40. Kong, L., L. Sun, H. Zhang, Q. Liu, Y. Liu, L. Qin, G. Shi, J.H. Hu, A. Xu, Y.P. Sun, D. Li, Y.F. Shi, J.W. Zang, J. Zhu, Z. Chen, Z.G. Wang, and B.X. Ge. An essential role for RIG-I in toll-like receptor-stimulated phagocytosis. Cell Host Microbe. 6: 150-161 (2009)
  41. Zhang, Y., L. Wang, D. Li, and N. Li. Taming regulatory T cells by autologous T cell immunization: a potential new strategy for cancer immune therapy. Int. Immunopharmacol. 9: 593-595 (2009)
  42. Li, C., H. Liu , Y. Sun, H. Wang, F. Guo, S. Rao, J. Deng, Y. Zhang , Y. Miao, C. Guo, J. Meng, X. Chen, L. Li, D. Li, H. Xu, H. Wang, B. Li, and C. Jiang. PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway. J. Mol. Cell Biol. 1: 37-45 (2009)
  43. Luan, B., J. Zhao, H. Wu, B. Duan, G. Shu, X. Wang, D. Li, W. Jia, J. Kang, and G. Pei. Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature 457: 1146-1149 (2009)
  44. Yu, M.C., L.L. Su, L. Zou, Y. Liu, N. Wu, L. Kong, Z.H. Zhuang, L. Sun, H.P. Liu, J.H. Hu, D. Li, J.L. Strominger, J.W. Zang, G. Pei, and B.X. Ge. An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat Immunol. 9: 898-907 (2008)
  45. Du, F., L. Wang, Y. Zhang, W. Jiang, H. Sheng, Q. Cao, J. Wu, B. Shen, T. Shen, J.Z. Zhang, C. Bao, D. Li, and N. Li. Role of GADD45 beta in the regulation of synovial fluid T cell apoptosis in rheumatoid arthritis. Clin Immunol. 128: 238-247 (2008)
  46. Cao, Q., L. Wang, F. Du, H. Sheng, Y. Zhang, J. Wu, B. Shen, T. Shen, J. Zhang, D. Li, and N. Li. Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells. Cell Res. 17: 627-637 (2007)
  47. Shi, Y., Y. Feng, J. Kang, C. Liu, Z. Li, D. Li, W. Cao, J. Qiu, Z. Guo, E. Bi, L. Zang, C. Lu, J.Z. Zhang, and G. Pei. Critical regulation of CD4(+) T cell survival and autoimmunity by beta-arrestin 1. Nat Immunol. 8: 817-824 (2007)
  48. *Li, D. Cancer research in China: a special focus by Cell Research. Cell Res. 17: 273 (2007)
  49. Das, S., J.C. Nwachukwu, D. Li, A.I. Vulin, S. Martinez-Caballero, K.W. Kinnally, and H.H. Samuels. The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events. Cancer Res. 15: 1775-1782 (2007)
  50. *Li, D. and G. Pei. A special issue on stem cell research. Cell Res. 17: 1-2 (2007)
  51. *Li, D. Selective degradation of the IkappaB kinase (IKK) by autophagy. Cell Res. 16: 855-856 (2006)
  52. *Li, D. Peaking of MMP-26 and TIMP-4 marks invasive transition in prostate cancer. Cell Res. 16: 741 (2006)
  53. *Li, D. GSK-3beta as a driving force in ovarian cancer. Cell Res. 16: 609 (2006)
  54. *Li, D. Endothelial progenitor cells in debate. Cell Res. 16: 529 (2006)
  55. *Li, D. PGC-1a: looking behind the sweet treat for porphyria. Cell 122: 487-489 (2005)
  56. Li, D., M.A. Mahajan, and H.H. Samuels. Functional consequences of interactions between thyroid hormone receptors and retinoid X receptor. Current Opinion in Endocrinology & Diabetes. 12: 356-362 (2005)  
  57. *Li, D., S. Das, T. Yamada, and H.H. Samuels. The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells. Mol. Cell. Biol. 24: 3838-3848 (2004)
  58. *Li, D., T. Yamada, F. Wang, A.I. Vulin, and H.H. Samuels. Novel roles of retinoid X receptor (RXR) and RXR ligand in dynamically modulating the activity of the thyroid hormone receptor/RXR heterodimer. J. Biol. Chem. 279: 7427-7437 (2004)
  59. Li, D., T. Li, F. Wang, H. Tian, and H.H. Samuels. Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer. Mol. Cell. Biol. 22: 5782-5792 (2002)
  60. Li, D., F. Wang, and H.H. Samuels. Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation. Mol. Cell. Biol. 21: 8371-8384 (2001)
  61. Li, D., V. Desai-Yajnik, E. Lo, M. Schapira, R. Abagyan, and H.H. Samuels. NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors. Mol. Cell. Biol. 19: 7191-7202 (1999)
  62. Rubin, B.P., D. Li, and W.K. Holloman. The Leu1 gene of Ustilago maydis. Gene 140: 131-135 (1994).              

          (* Corresponding author)

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