人才队伍

情况简介
院士风采
杰出青年
全所PI名录
 
 
地址:上海市岳阳路320号
邮编:200031
电话:86-21-54920000
传真:86-21-54921011
邮箱:sibcb@sibcb.ac.cn

全所PI名录 >

 
王红艳
研究员,研究组长,博士生导师
E-mail: hongyanwang@@sibcb.ac.cn


个人简介

1993-1998 年安徽医科大学临床医学系本科;1998-2001 年安徽医科大学免疫系和中国预防医学科学院病毒所基因工程国家重点实验室联合培养硕士;2001-2006 英国伦敦帝国理工学院(Imperial College London)博士及Research Associate; 2006-2010 英国剑桥大学Research Fellow;2010年3月任生化与细胞所研究员,研究组长;2011年入选中国科学院百人计划及上海市浦江人才计划。2014年获国家基金委优秀青年资助。2018年获国家自然基金委杰出青年资助。2015年获中国科学院优秀指导老师称号。


研究方向

免疫细胞介导的炎症相关疾病


研究工作

        免疫介导的炎症相关疾病主要由于不适当或过度免疫反应造成的慢性和急性炎症反应。其中,免疫系统中的T淋巴细胞和巨噬细胞能分泌各种炎症/细胞因子,广泛参与肿瘤或自身免疫性疾病的发生发展、机体抵御病原微生物感染的过程。(1)巨噬细胞通过Toll-样受体等模式识别受体,感知病原微生物的各种组分,激活NF-kB、IRFs等各种转录因子,释放促炎因子(IL-6,IL-1, TNF-alpha)或抑炎因子(IL-10),或抗病毒的IFNs,调控炎症反应,参与病原微生物感染和炎性癌变等过程。(2)在应对炎症反应或异种抗原时,T淋巴细胞通过表面的众多受体(如T细胞受体,趋化因子受体等),调控T细胞定向迁移到感染或肿瘤等靶部位,增殖分化成具有杀伤功能的细胞毒性T淋巴细胞(CTL),参与清除病原微生物或杀伤肿瘤细胞的过程。
        我们利用基因工程突变小鼠及相应疾病模型,结合病人样品,在分子、细胞水平,主要鉴定:(1)参与T细胞活化、增殖、迁移和杀伤功能的新型信号分子;(2)巨噬细胞调控炎症反应和I型IFN的新型信号分子;(3) 上述信号分子、代谢酶或产物等调控巨噬细胞和T细胞参与抗感染、抗肿瘤或促进损伤修复中的功能和机制。
左图Immunity, 2014, Cover Story; 中图:Cell Research, 2015, Cover Story;右图:PLoS Pathogens, 2015


代表性论文

  1. X Zhou, WY Li S Wang, P Zhang, Q Wang, J Xiao, C Zhang, X Zheng, X Xu, S Xue, L Hui, H Ji, B Wei#, H Wang#. YAP aggravates inflammatory bowel disease (IBD) via regulating M1/M2 macrophage polarization and gut microbial homeostasis. Cell Reports, 2019
  2. Y Lu*, Y Qiu*, P Chen, H Chang, L Guo, F Zhang, L Ma, C Zhang, X Zheng, J Xiao, R Zhong, L Han, X Xu, Y Zhang, D Li, G Zhong, R Boyton, Y Huang, Y He, R Hu#, B Wei#, H Wang# The ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection, Nature Microbiology, 2019 Accepted in principle
  3. T Zhou#, MC Luo, W Cai, SY Zhou, DY Feng, CD Xu, H. Wang#. Runt-related transcription factor 1 (RUNX1) promotes TGF-β-induced renal tubular epithelial-to-mesenchymal transition (EMT) and renal fibrosis through the PI3K subunit p110δ. EBioMedicine, 2018.31:217-225
  4. XY Xu, L Han, G. Zhao, SJ Xue, Y Gao, J Xiao, ZY Wu, JP Ding, B Wei, RG Hu, H Wang. LRCH1 interferes with DOCK8-Cdc42 module-induced T cell migration and ameliorates multiple sclerosis. J Exp Med, 2017; 214(1):209-226.
  5. SJ Xue, C Liu, XJ Sun, WY Li, C Zhang, X Zhou, Y Lu, J Xiao, CY Li, XY Xu, B Sun, GL Xu, H Wang. TET3 inhibits IFN-I production independent of DNA demethylation. Cell Reports, 2016;16:1-10
  6. W Li, J Xiao, X Zhou, M Xu, C Hu, X Xu, Y Lu, C Liu, S Xue, L Nie, H Zhang, Z Li, Y Zhang, F Ji, L Hui, W Tao, B Wei# and H Wang#. STK4 regulates TLR pathways and protects against chronic inflammation–related hepatocellular carcinoma. The Journal of Clinical Investigation, 2015; 125(11):4239-54
  7. Li C, Li W, Xiao J, Jiao S, Sheng C, Rudd CE, Wei B, Wang H#. ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy. EMBO Mol Med, 2015: e201404578
  8. Jiao S, Li C, Wang G, Gao Y, He X, Liu C, Zhang G, Wei B, Chen H, Wang H#. The immune adaptor ADAP regulates reciprocal TGF-β1-integrin crosstalk to protect from H5N1 influenza virus infection. PLoS Pathogens, 2015, 11(4):e1004824
  9. Fu X, Xiao J, Wei Y, Guo H, Li S, Liu Y, Yin J, Li D, Wang H#, Hu P#. Combination of four pro-inflammatory cytokines promotes long term muscle stem cell expansion in vitro. Cell Research, 2015, May 15. doi: 10.1038/cr.2015.58 (Cover Story)
  10. Zhang Y, Lu Y, Ma L, Jiao S, Chen J, Gao Y, Liu C, Duan Z, Li D, He Y, Wei B#, Wang H# Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR-NF-κB signaling and protects from endotoxin shock Immunity, 2014, 40: 501-514 (Cover Story)
  11. Huang Y, Jiao S, Tao X, Tang Q#, Jiao W, Xiao J, Xu X, Zhang Y, Liang G, Wang H # Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection. J Neuroinflammation 2014,11:146
  12. Zhang M, Zhou H, Zheng C, Xiao J, Zuo E, Liu W, Xie D, Shi Y, Wu C, Wang H, Li D, Li J. The Roles of Testicular C-kit Positive Cells in De novo Morphogenesis of Testis. Sci Rep 2014; 4: 5936; 1-11
  13. Yu T, Tao Y, Yang1 M, Chen P, Gao X, Zhang Y, Zhang T, Chen Z, Hou J, Zhang Y, Ruan K, Wang H, Hu R. Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis. Cell Res. 2014:1-17
  14. Wei B*, Han L*, Abbink T, Elisabetta G, Lim D, Thaker YR, Gao W, Zhai R, Wang J, Lever A, Jolly C, Wang H# and Rudd CE#. Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. Retrovirology, 2013:10:101
  15. Zhang Y and Wang H#. Integrin signaling and function in immune cells. Immunology, 2012;4(135):267-75
  16. Li C, Xu X, Wang H# and Wei B#. PD-1 and CTLA-4 mediated inhibitory signaling for T cell exhaustion during chronic viral infections. Journal of Clinical & Cellular Immunology, 2012, S7-10.
  17. Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res. 2012;22(5):836-47.
  18. Wang H#, Lim D and Rudd CE. Integrin signaling and immunopathology Semin Immunopathol 2010;32(2):173-82
  19. Raab M, Wang H, Lu Y, Smith X, Wu Z, Strebhardt K, Ladbury JE, Rudd CE. T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Immunity 2010;32(4):541-56.
  20. Wang H, Lv Y and Rudd CE. SKAP1 is dispensable for chemokine induced T-cell migration. Immunol Letters 2010:128(2):148-53.
  21. Wang H, Wei B, Bismuth G, Rudd CE. SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility. PNAS 2009; 106(30):12436-41.
  22. Wang H and Rudd CE. SKAP-55, SKAP-55Related and ADAP adaptors modulate integrin-mediated immune cell adhesion. Trends Cell Biol 2008; 18(10):486-93.
  23. Schenider H*, Wang H*, Raab M, Valk E, Smith X, Lovatt M, Wu, Z, Strebhardt K, Rudd CE. Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-Cells. PLoS ONE. 2008;5;3(3):e1718 
  24. Wang H, Liu H, Lu Y, Lovatt M, Wei B, Rudd CE. Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol Cell Biol. 2007;27(19):6863-75
  25. Wei B, da Rocha Dias S, Wang H, Rudd CE. CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase. J Immunol. 2007;179(1):400-8.
  26. Jo E-K, Wang H, and Rudd CE. An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R. J. Exp. Med. 2005;201(11):1733-9.
  27. Wang H, McCane F, Gordan J, Wu X, Raab M, Malik T, Davis D, Rudd CE. ADAP-SLP-76 binding differently regulates the supramolecular activation complex (SMAC) formation vs. conjugate formation. J. Exp. Med. 2004;200:1063-1074
  28. Wang H*, Moon EY*, Azouz A, Wu X, Smith A, Schneider H, Hogg N, Rudd CE. SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. Nat Immunol. 2003;4(4):366-74.
  29. Rudd CE, Wang H. Hematopoietic adaptors in T-cell signaling: potential applications to transplantation. Am J Transplant. 2003;3(10):1204-10.
  30. Wilkinson B, Wang H, Rudd CE. Positive and negative adaptors in T cell signaling. Immunology 2004;111(4): 368-374.

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